Photocytotoxic activity of a nitrosyl phthalocyanine ruthenium complex — A system capable of producing nitric oxide and singlet oxygen
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5399 |
Resumo: | texto completo: acesso restrito. p. 1035–1043. |
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Carneiro, Zumira AparecidaMoraes, Juliana Cristina Biazzotto deRodrigues, Fernando PostalliLima, Renata Galvão deCurti, CarlosRocha, Zênis Novaes daPaulo, MicheleBendhack, Lusiane MariaTedesco, Antonio ClaudioFormiga, André Luiz BarbozaSilva, Roberto Santana daCarneiro, Zumira AparecidaMoraes, Juliana Cristina Biazzotto deRodrigues, Fernando PostalliLima, Renata Galvão deCurti, CarlosRocha, Zênis Novaes daPaulo, MicheleBendhack, Lusiane MariaTedesco, Antonio ClaudioFormiga, André Luiz BarbozaSilva, Roberto Santana da2012-02-13T20:28:40Z20111873-3344http://www.repositorio.ufba.br/ri/handle/ri/5399v. 105.texto completo: acesso restrito. p. 1035–1043.The synthesis, structural aspects, pharmacological assays, and in vitro photoinduced cytotoxic properties of [Ru(NO)(ONO)(pc)] (pc = phthalocyanine) are described. Its biological effect on the B16F10 cell line was studied in the presence and absence of visible light irradiation. At comparable irradiation levels, [Ru(NO) (ONO)(pc)] was more effective than [Ru(pc)] at inhibiting cell growth, suggesting that occurrence of nitric oxide release following singlet oxygen production upon light irradiation may be an important mechanism by which the nitrosyl ruthenium complex exhibits enhanced biological activity in cells. Following visible light activation, the [Ru(NO)(ONO)(pc)] complex displayed increased potency in B16F10 cells upon modifications to the photoinduced dose; indeed, enhanced potency was detected when the nitrosyl ruthenium complex was encapsulated in a drug delivery system. The liposome containing the [Ru(NO)(ONO)(pc)] complex was over 25% more active than the corresponding ruthenium complex in phosphate buffer solution. The activity of the complex was directly proportional to the ruthenium amount present inside the cell, as determined by inductively coupled plasma mass spectroscopy. Flow cytometry analysis revealed that the photocytotoxic activity was mainly due to apoptosis. Furthermore, the vasorelaxation induced by [Ru(NO)(ONO)(pc)], proposed as NO carrier, was studied in rat isolated aorta. The observed vasodilation was concentrationdependent. Taken together, the present findings demonstrate that the [Ru(NO)(ONO)(pc)] complex induces vascular relaxation and could be a potent anti-tumor agent. Nitric oxide release following singlet oxygen production upon visible light irradiation on a nitrosyl ruthenium complex produces two radicals and may elicit phototoxic responses that may find useful applications in photodynamic therapy.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2012-02-13T20:28:40Z No. of bitstreams: 1 __pdn.sciencedirect.com_....0-S0162013411001073-main.pdf: 440339 bytes, checksum: c1ab70e5283b85632e2ac1a894823a34 (MD5)Made available in DSpace on 2012-02-13T20:28:40Z (GMT). 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| dc.title.pt_BR.fl_str_mv |
Photocytotoxic activity of a nitrosyl phthalocyanine ruthenium complex — A system capable of producing nitric oxide and singlet oxygen |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Inorganic Biochemistry |
| title |
Photocytotoxic activity of a nitrosyl phthalocyanine ruthenium complex — A system capable of producing nitric oxide and singlet oxygen |
| spellingShingle |
Photocytotoxic activity of a nitrosyl phthalocyanine ruthenium complex — A system capable of producing nitric oxide and singlet oxygen Carneiro, Zumira Aparecida Nitric oxide Photocytotoxic activity Nitrosyl ruthenium complex |
| title_short |
Photocytotoxic activity of a nitrosyl phthalocyanine ruthenium complex — A system capable of producing nitric oxide and singlet oxygen |
| title_full |
Photocytotoxic activity of a nitrosyl phthalocyanine ruthenium complex — A system capable of producing nitric oxide and singlet oxygen |
| title_fullStr |
Photocytotoxic activity of a nitrosyl phthalocyanine ruthenium complex — A system capable of producing nitric oxide and singlet oxygen |
| title_full_unstemmed |
Photocytotoxic activity of a nitrosyl phthalocyanine ruthenium complex — A system capable of producing nitric oxide and singlet oxygen |
| title_sort |
Photocytotoxic activity of a nitrosyl phthalocyanine ruthenium complex — A system capable of producing nitric oxide and singlet oxygen |
| author |
Carneiro, Zumira Aparecida |
| author_facet |
Carneiro, Zumira Aparecida Moraes, Juliana Cristina Biazzotto de Rodrigues, Fernando Postalli Lima, Renata Galvão de Curti, Carlos Rocha, Zênis Novaes da Paulo, Michele Bendhack, Lusiane Maria Tedesco, Antonio Claudio Formiga, André Luiz Barboza Silva, Roberto Santana da |
| author_role |
author |
| author2 |
Moraes, Juliana Cristina Biazzotto de Rodrigues, Fernando Postalli Lima, Renata Galvão de Curti, Carlos Rocha, Zênis Novaes da Paulo, Michele Bendhack, Lusiane Maria Tedesco, Antonio Claudio Formiga, André Luiz Barboza Silva, Roberto Santana da |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Carneiro, Zumira Aparecida Moraes, Juliana Cristina Biazzotto de Rodrigues, Fernando Postalli Lima, Renata Galvão de Curti, Carlos Rocha, Zênis Novaes da Paulo, Michele Bendhack, Lusiane Maria Tedesco, Antonio Claudio Formiga, André Luiz Barboza Silva, Roberto Santana da Carneiro, Zumira Aparecida Moraes, Juliana Cristina Biazzotto de Rodrigues, Fernando Postalli Lima, Renata Galvão de Curti, Carlos Rocha, Zênis Novaes da Paulo, Michele Bendhack, Lusiane Maria Tedesco, Antonio Claudio Formiga, André Luiz Barboza Silva, Roberto Santana da |
| dc.subject.por.fl_str_mv |
Nitric oxide Photocytotoxic activity Nitrosyl ruthenium complex |
| topic |
Nitric oxide Photocytotoxic activity Nitrosyl ruthenium complex |
| description |
texto completo: acesso restrito. p. 1035–1043. |
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2011 |
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2011 |
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2012-02-13T20:28:40Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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1873-3344 |
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v. 105. |
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1873-3344 v. 105. |
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http://www.repositorio.ufba.br/ri/handle/ri/5399 |
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eng |
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openAccess |
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doi:10.1016/j.jinorgbio.2011.04.011 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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