Central kappa opioid receptors modulate salt appetite in rats

Detalhes bibliográficos
Autor(a) principal: Nascimento, Ana Isabel Reis
Data de Publicação: 2012
Outros Autores: Ferreira, Hilda Silva, Saraiva, Raquel Moreira, Almeida, Tatiana Silva de, Fregoneze, Josmara Bartolomei
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15758
Resumo: Texto completo: acesso restrito. p. 506–514
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spelling Nascimento, Ana Isabel ReisFerreira, Hilda SilvaSaraiva, Raquel MoreiraAlmeida, Tatiana Silva deFregoneze, Josmara BartolomeiNascimento, Ana Isabel ReisFerreira, Hilda SilvaSaraiva, Raquel MoreiraAlmeida, Tatiana Silva deFregoneze, Josmara Bartolomei2014-09-01T16:56:00Z20120031-9384http://repositorio.ufba.br/ri/handle/ri/15758v. 106, n. 4Texto completo: acesso restrito. p. 506–514The role of the central opioid system in the control of water and salt intake is complex, with both stimulatory and inhibitory effects having been observed. The aim of the present study was to investigate the participation of the central κ-opioid receptors in the control of salt appetite. Male Wistar rats were submitted to two different experimental protocols: sodium deficit produced by the diuretic, furosemide, and brain angiotensinergic stimulation in rats under normal sodium balance. Lateral ventricle (LV) injections of Nor-binaltorphimine (Nor-BNI) at different doses (5, 10 and 20 nmol) inhibited hypertonic saline solution (1.5%) intake in sodium-depleted rats. The salt appetite induced by an LV injection of angiotensin II (AngII) (10 ng) was also blocked by Nor-BNI injections into the LV, while no significant change was observed in water intake. Furthermore, the decrease in salt intake seems not to have been due to a general inhibition of locomotor activity or to any change in palatability, since central administration of Nor-BNI failed to modify the intake of a 0.1% saccharin solution when the animals were submitted to a “dessert test” or to induce any significant locomotor deficit in the open-field test. Also the central administration of Nor-BNI was unable to modify blood pressure in sodium-depleted animals. The present results suggest that activation of endogenous κ-opioid receptors modulates salt appetite induced by sodium depletion and by central angiotensinergic stimulation in rats.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-09-01T11:49:39Z No. of bitstreams: 1 A. I. R. Nascimento.pdf: 979422 bytes, checksum: ecc141197a16a3c916ae6ce1922b38c3 (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-09-01T16:56:00Z (GMT) No. of bitstreams: 1 A. I. R. Nascimento.pdf: 979422 bytes, checksum: ecc141197a16a3c916ae6ce1922b38c3 (MD5)Made available in DSpace on 2014-09-01T16:56:00Z (GMT). No. of bitstreams: 1 A. I. R. Nascimento.pdf: 979422 bytes, checksum: ecc141197a16a3c916ae6ce1922b38c3 (MD5) Previous issue date: 2012http://dx.doi.org/ 10.1016/j.physbeh.2012.03.028reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAKappa opioid receptorsSalt intakeSodium depletionAngiotensinCentral kappa opioid receptors modulate salt appetite in ratsPhysiology and Behaviorinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALA. I. R. Nascimento.pdfA. I. R. Nascimento.pdfapplication/pdf979422https://repositorio.ufba.br/bitstream/ri/15758/1/A.%20I.%20R.%20Nascimento.pdfecc141197a16a3c916ae6ce1922b38c3MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15758/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTA. I. R. Nascimento.pdf.txtA. I. R. 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dc.title.pt_BR.fl_str_mv Central kappa opioid receptors modulate salt appetite in rats
dc.title.alternative.pt_BR.fl_str_mv Physiology and Behavior
title Central kappa opioid receptors modulate salt appetite in rats
spellingShingle Central kappa opioid receptors modulate salt appetite in rats
Nascimento, Ana Isabel Reis
Kappa opioid receptors
Salt intake
Sodium depletion
Angiotensin
title_short Central kappa opioid receptors modulate salt appetite in rats
title_full Central kappa opioid receptors modulate salt appetite in rats
title_fullStr Central kappa opioid receptors modulate salt appetite in rats
title_full_unstemmed Central kappa opioid receptors modulate salt appetite in rats
title_sort Central kappa opioid receptors modulate salt appetite in rats
author Nascimento, Ana Isabel Reis
author_facet Nascimento, Ana Isabel Reis
Ferreira, Hilda Silva
Saraiva, Raquel Moreira
Almeida, Tatiana Silva de
Fregoneze, Josmara Bartolomei
author_role author
author2 Ferreira, Hilda Silva
Saraiva, Raquel Moreira
Almeida, Tatiana Silva de
Fregoneze, Josmara Bartolomei
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Nascimento, Ana Isabel Reis
Ferreira, Hilda Silva
Saraiva, Raquel Moreira
Almeida, Tatiana Silva de
Fregoneze, Josmara Bartolomei
Nascimento, Ana Isabel Reis
Ferreira, Hilda Silva
Saraiva, Raquel Moreira
Almeida, Tatiana Silva de
Fregoneze, Josmara Bartolomei
dc.subject.por.fl_str_mv Kappa opioid receptors
Salt intake
Sodium depletion
Angiotensin
topic Kappa opioid receptors
Salt intake
Sodium depletion
Angiotensin
description Texto completo: acesso restrito. p. 506–514
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-09-01T16:56:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15758
dc.identifier.issn.none.fl_str_mv 0031-9384
dc.identifier.number.pt_BR.fl_str_mv v. 106, n. 4
identifier_str_mv 0031-9384
v. 106, n. 4
url http://repositorio.ufba.br/ri/handle/ri/15758
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.1016/j.physbeh.2012.03.028
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