Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β

Detalhes bibliográficos
Autor(a) principal: Luz, P. A.
Data de Publicação: 2009
Outros Autores: Saraiva, R., Almeida, T., Fregoneze, J. B., Castro e Silva, E. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13323
Resumo: Texto completo: acesso restrito. p. 93-103
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spelling Luz, P. A.Saraiva, R.Almeida, T.Fregoneze, J. B.Castro e Silva, E. de2013-10-30T16:35:46Z20090143-4179http://repositorio.ufba.br/ri/handle/ri/13323v. 43, n. 2Texto completo: acesso restrito. p. 93-103The objective of the present study was to investigate the role of brain kappa-opioid receptors (KOR) in the antidipsogenic effect promoted by third ventricle injections of interleukin-1β (IL-1β). Wistar male rats were submitted to three different, thirst-inducing, physiological conditions: dehydration induced by water deprivation, hyperosmolarity induced by salt-load and hypovolemia induced by polyethylene glycol subcutaneous injection. Third ventricle injections of IL-1β significantly inhibited the increase in water intake observed in those situations. The pharmacological blockade of central KOR by the selective KOR antagonist nor-binaltorphimine (BNI) at different doses significantly inhibited the antidipsogenic effect induced by the central administration of IL-1β in all conditions tested: dehydration, hypovolemia and hyperosmolarity. The central administration of IL-1β failed to induce any locomotor deficit, as verified in an open field test. Stimulation of the central interleukinergic component did not result in any general suppression of ingestive behavior since no change in saccharin intake was recorded during a dessert test in animals receiving central injections of IL-1β. Furthermore, the inhibitory effects of IL-1β on water intake cannot be attributed to sickness-like effects induced by these compounds, since an aversion test excluded this possibility. In summary, the data shown in the present study clearly show that the antidipsogenic effect observed in rats following third ventricle injections of IL-1β depend on the functional integrity of a brain kappa-opioid-dependent component.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-10-15T14:04:34Z No. of bitstreams: 1 1-s2.0-S014341790900002X-main.pdf: 866064 bytes, checksum: f156079f5d37f1d1fb2c67459a0cde64 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-10-30T16:35:46Z (GMT) No. of bitstreams: 1 1-s2.0-S014341790900002X-main.pdf: 866064 bytes, checksum: f156079f5d37f1d1fb2c67459a0cde64 (MD5)Made available in DSpace on 2013-10-30T16:35:46Z (GMT). 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dc.title.pt_BR.fl_str_mv Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β
dc.title.alternative.pt_BR.fl_str_mv Neuropeptides
title Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β
spellingShingle Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β
Luz, P. A.
Interleukin
Water intake
Opioids
Kappa-opioid receptors
Hypovolemia
Dehydration
Hyperosmolarity
title_short Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β
title_full Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β
title_fullStr Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β
title_full_unstemmed Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β
title_sort Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β
author Luz, P. A.
author_facet Luz, P. A.
Saraiva, R.
Almeida, T.
Fregoneze, J. B.
Castro e Silva, E. de
author_role author
author2 Saraiva, R.
Almeida, T.
Fregoneze, J. B.
Castro e Silva, E. de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Luz, P. A.
Saraiva, R.
Almeida, T.
Fregoneze, J. B.
Castro e Silva, E. de
dc.subject.por.fl_str_mv Interleukin
Water intake
Opioids
Kappa-opioid receptors
Hypovolemia
Dehydration
Hyperosmolarity
topic Interleukin
Water intake
Opioids
Kappa-opioid receptors
Hypovolemia
Dehydration
Hyperosmolarity
description Texto completo: acesso restrito. p. 93-103
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2013-10-30T16:35:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13323
dc.identifier.issn.none.fl_str_mv 0143-4179
dc.identifier.number.pt_BR.fl_str_mv v. 43, n. 2
identifier_str_mv 0143-4179
v. 43, n. 2
url http://repositorio.ufba.br/ri/handle/ri/13323
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.country.fl_str_mv Brasil
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.npep.2008.12.006
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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