Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/16014 |
Resumo: | Texto completo: acesso restrito. p. 788-793 |
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Machado, Paulo Roberto LimaLessa, Hélio AndradeLessa, MarcusGuimarães, Luiz H.Bang, HeejungHo, John L.Carvalho Filho, Edgar Marcelino deMachado, Paulo Roberto LimaLessa, Hélio AndradeLessa, MarcusGuimarães, Luiz H.Bang, HeejungHo, John L.Carvalho Filho, Edgar Marcelino de2014-09-09T16:15:25Z20071058-4838http://repositorio.ufba.br/ri/handle/ri/16014v. 44, n. 6Texto completo: acesso restrito. p. 788-793Background. Mucosal leishmaniasis is associated with intense tissue damage and high tumor necrosis factor–α production. Therapeutic failure occurs in up to 42% of cases; patients who experience treatment failure will require >1 pentavalent antimony (Sbv) course or alternative drugs to achieve a cure. We previously showed that an inhibitor of tumor necrosis factor–α (pentoxifylline) combined with Sbv cured 90% patients refractory to monotherapy with Sbv. Methods. A double-blind, placebo-controlled trial involving 23 patients with mucosal leishmaniasis evaluated the efficacy of pentoxifylline when administered in association with Sbv, compared with Sbv treatment alone. Eleven patients were randomized to receive Sbv plus oral pentoxifylline for 30 days, and 12 patients received Sbv plus oral placebo. The criterion for cure was a complete healing of lesions. Results. All patients in the pentoxifylline group experienced a cure with 1 course of Sbv, whereas 5 (41.6%) of 12 patients in the placebo group required a second course of Sbv (P = .037). The healing time ± standard deviation in the pentoxifylline group was 83 ± 36 days, compared with 145 ± 99 days in the placebo group (P = .049). No relapses were documented in either group at the 2-year follow-up visit. Conclusions. The addition of pentoxifylline to Sbv in mucosal leishmaniasis reduces the healing time significantly and prevents the need for further courses of Sbv.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-01-31T15:27:27Z No. of bitstreams: 1 10.1086-511643.pdf: 148831 bytes, checksum: f27d89c43b44be61ee73ba5de58ceaac (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-09-09T16:15:25Z (GMT) No. of bitstreams: 1 10.1086-511643.pdf: 148831 bytes, checksum: f27d89c43b44be61ee73ba5de58ceaac (MD5)Made available in DSpace on 2014-09-09T16:15:25Z (GMT). No. of bitstreams: 1 10.1086-511643.pdf: 148831 bytes, checksum: f27d89c43b44be61ee73ba5de58ceaac (MD5) Previous issue date: 2007http://dx.doi.org/10.1086/511643reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAOral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasisClinical Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL10.1086-511643.pdf10.1086-511643.pdfapplication/pdf148831https://repositorio.ufba.br/bitstream/ri/16014/1/10.1086-511643.pdff27d89c43b44be61ee73ba5de58ceaacMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16014/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT10.1086-511643.pdf.txt10.1086-511643.pdf.txtExtracted texttext/plain26615https://repositorio.ufba.br/bitstream/ri/16014/3/10.1086-511643.pdf.txt539b85d2251c9b86fb2c110a1a3dc0ecMD53ri/160142022-07-05 14:03:00.049oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis |
dc.title.alternative.pt_BR.fl_str_mv |
Clinical Infectious Diseases |
title |
Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis |
spellingShingle |
Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis Machado, Paulo Roberto Lima |
title_short |
Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis |
title_full |
Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis |
title_fullStr |
Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis |
title_full_unstemmed |
Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis |
title_sort |
Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis |
author |
Machado, Paulo Roberto Lima |
author_facet |
Machado, Paulo Roberto Lima Lessa, Hélio Andrade Lessa, Marcus Guimarães, Luiz H. Bang, Heejung Ho, John L. Carvalho Filho, Edgar Marcelino de |
author_role |
author |
author2 |
Lessa, Hélio Andrade Lessa, Marcus Guimarães, Luiz H. Bang, Heejung Ho, John L. Carvalho Filho, Edgar Marcelino de |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Machado, Paulo Roberto Lima Lessa, Hélio Andrade Lessa, Marcus Guimarães, Luiz H. Bang, Heejung Ho, John L. Carvalho Filho, Edgar Marcelino de Machado, Paulo Roberto Lima Lessa, Hélio Andrade Lessa, Marcus Guimarães, Luiz H. Bang, Heejung Ho, John L. Carvalho Filho, Edgar Marcelino de |
description |
Texto completo: acesso restrito. p. 788-793 |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007 |
dc.date.accessioned.fl_str_mv |
2014-09-09T16:15:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufba.br/ri/handle/ri/16014 |
dc.identifier.issn.none.fl_str_mv |
1058-4838 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 44, n. 6 |
identifier_str_mv |
1058-4838 v. 44, n. 6 |
url |
http://repositorio.ufba.br/ri/handle/ri/16014 |
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eng |
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eng |
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openAccess |
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http://dx.doi.org/10.1086/511643 |
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