Antiproliferative, proapoptotic and morphogenic effects of the flavonoid rutin on human glioblastoma cells
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/14748 |
Resumo: | Texto completo: acesso restrito. p. 404–411 |
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Santos, B. L.Silva, A. R.Pitanga, B. P. S.Sousa, C. S.Grangeiro, M. S.Fragomeni, B. O.Coelho, P. L. C.Oliveira, M. N.Menezes Filho, N. J.Costa, Maria de Fátima DiasEl-Bachá, Ramon dos SantosVelozo, Eudes da SilvaSampaio, G. P.Freire, S. M.Tardy, Marcienne BlochCosta, Silvia LimaSantos, B. L.Silva, A. R.Pitanga, B. P. S.Sousa, C. S.Grangeiro, M. S.Fragomeni, B. O.Coelho, P. L. C.Oliveira, M. N.Menezes Filho, N. J.Costa, Maria de Fátima DiasEl-Bachá, Ramon dos SantosVelozo, Eudes da SilvaSampaio, G. P.Freire, S. M.Tardy, Marcienne BlochCosta, Silvia Lima2014-03-13T18:23:05Z20110308-8146http://repositorio.ufba.br/ri/handle/ri/14748v. 127, n. 2Texto completo: acesso restrito. p. 404–411In this study, we investigated the effects of the flavonoid rutin (3,3′,4′,5,7-pentahydroxyflavone-3-rutinoside) on glioma cells, using the highly proliferative human cell line GL-15 as a model. We observed that rutin (50–100 μM) reduced proliferation and viability of GL-15 cells, leading to decreased levels of ERK1/2 phosphorylation (P-ERK1/2) and accumulation of cells in the G2 phase of the cell cycle. On the other hand, 87.4% of GL-15 cells exposed to 100 μM rutin entered apoptosis, as revealed by flow cytometry after AnnexinV/PI staining. Nuclear condensation and DNA fragmentation were also observed, further confirming that apoptosis had occurred. Moreover, the remaining cells that were treated with 50 μM rutin presented a morphological pattern of astroglial differentiation in culture, characterised by a condensed cell body and thin processes with overexpression of GFAP. Because of its capacity to induce differentiation and apoptosis in cultured human glioblastoma cells, rutin could be considered as a potential candidate for malignant gliomas treatment.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-03-12T14:10:41Z No. of bitstreams: 1 B. L. Santos.pdf: 890946 bytes, checksum: 60964c86955f5c907304011c08596b7a (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-03-13T18:23:05Z (GMT) No. of bitstreams: 1 B. L. Santos.pdf: 890946 bytes, checksum: 60964c86955f5c907304011c08596b7a (MD5)Made available in DSpace on 2014-03-13T18:23:05Z (GMT). No. of bitstreams: 1 B. L. Santos.pdf: 890946 bytes, checksum: 60964c86955f5c907304011c08596b7a (MD5) Previous issue date: 2011http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.foodchem.2010.12.131reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBARutinFlavonoidGliomasApoptosisDifferentiationP-ERKGFAPAntiproliferative, proapoptotic and morphogenic effects of the flavonoid rutin on human glioblastoma cellsFood Chemistryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALB. L. Santos.pdfB. L. 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| dc.title.pt_BR.fl_str_mv |
Antiproliferative, proapoptotic and morphogenic effects of the flavonoid rutin on human glioblastoma cells |
| dc.title.alternative.pt_BR.fl_str_mv |
Food Chemistry |
| title |
Antiproliferative, proapoptotic and morphogenic effects of the flavonoid rutin on human glioblastoma cells |
| spellingShingle |
Antiproliferative, proapoptotic and morphogenic effects of the flavonoid rutin on human glioblastoma cells Santos, B. L. Rutin Flavonoid Gliomas Apoptosis Differentiation P-ERK GFAP |
| title_short |
Antiproliferative, proapoptotic and morphogenic effects of the flavonoid rutin on human glioblastoma cells |
| title_full |
Antiproliferative, proapoptotic and morphogenic effects of the flavonoid rutin on human glioblastoma cells |
| title_fullStr |
Antiproliferative, proapoptotic and morphogenic effects of the flavonoid rutin on human glioblastoma cells |
| title_full_unstemmed |
Antiproliferative, proapoptotic and morphogenic effects of the flavonoid rutin on human glioblastoma cells |
| title_sort |
Antiproliferative, proapoptotic and morphogenic effects of the flavonoid rutin on human glioblastoma cells |
| author |
Santos, B. L. |
| author_facet |
Santos, B. L. Silva, A. R. Pitanga, B. P. S. Sousa, C. S. Grangeiro, M. S. Fragomeni, B. O. Coelho, P. L. C. Oliveira, M. N. Menezes Filho, N. J. Costa, Maria de Fátima Dias El-Bachá, Ramon dos Santos Velozo, Eudes da Silva Sampaio, G. P. Freire, S. M. Tardy, Marcienne Bloch Costa, Silvia Lima |
| author_role |
author |
| author2 |
Silva, A. R. Pitanga, B. P. S. Sousa, C. S. Grangeiro, M. S. Fragomeni, B. O. Coelho, P. L. C. Oliveira, M. N. Menezes Filho, N. J. Costa, Maria de Fátima Dias El-Bachá, Ramon dos Santos Velozo, Eudes da Silva Sampaio, G. P. Freire, S. M. Tardy, Marcienne Bloch Costa, Silvia Lima |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, B. L. Silva, A. R. Pitanga, B. P. S. Sousa, C. S. Grangeiro, M. S. Fragomeni, B. O. Coelho, P. L. C. Oliveira, M. N. Menezes Filho, N. J. Costa, Maria de Fátima Dias El-Bachá, Ramon dos Santos Velozo, Eudes da Silva Sampaio, G. P. Freire, S. M. Tardy, Marcienne Bloch Costa, Silvia Lima Santos, B. L. Silva, A. R. Pitanga, B. P. S. Sousa, C. S. Grangeiro, M. S. Fragomeni, B. O. Coelho, P. L. C. Oliveira, M. N. Menezes Filho, N. J. Costa, Maria de Fátima Dias El-Bachá, Ramon dos Santos Velozo, Eudes da Silva Sampaio, G. P. Freire, S. M. Tardy, Marcienne Bloch Costa, Silvia Lima |
| dc.subject.por.fl_str_mv |
Rutin Flavonoid Gliomas Apoptosis Differentiation P-ERK GFAP |
| topic |
Rutin Flavonoid Gliomas Apoptosis Differentiation P-ERK GFAP |
| description |
Texto completo: acesso restrito. p. 404–411 |
| publishDate |
2011 |
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2011 |
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2014-03-13T18:23:05Z |
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0308-8146 |
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v. 127, n. 2 |
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0308-8146 v. 127, n. 2 |
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http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.foodchem.2010.12.131 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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