Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil

Detalhes bibliográficos
Autor(a) principal: Adorno, Elisângela Vitória
Data de Publicação: 2005
Outros Autores: Couto, Fábio David, Moura Neto, José Pereira de, Menezes, Joelma Figueiredo, Rêgo, Marco Antônio Vasconcelos, Reis, Mitermayer Galvão dos, Gonçalves, Marilda Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/2890
Resumo: p. 292-298
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spelling Adorno, Elisângela VitóriaCouto, Fábio DavidMoura Neto, José Pereira deMenezes, Joelma FigueiredoRêgo, Marco Antônio VasconcelosReis, Mitermayer Galvão dosGonçalves, Marilda SouzaAdorno, Elisângela VitóriaCouto, Fábio DavidMoura Neto, José Pereira deMenezes, Joelma FigueiredoRêgo, Marco Antônio VasconcelosReis, Mitermayer Galvão dosGonçalves, Marilda Souza2011-09-27T13:15:03Z2011-09-27T13:15:03Z20050102-311Xhttp://www.repositorio.ufba.br/ri/handle/ri/289021(1)p. 292-298Hemoglobinopathies are hereditary disorders of the hemoglobin molecule with a high prevalence worldwide. Brazil has a prevalence of 0.1 to 0.3% of newborns with sickle cell anemia and 20.0 to 25.0% of heterozygous α2 thalassemia among African Brazilians. In the present study, we investigated the presence of variant emoglobins and α2 3.7 Kb and α2 4.2 Kb thalassemia in newborns from Salvador, Bahia, Brazil. Samples of umbilical cord blood from a total of 590 newborns were analyzed, of which 57 (9.8%) were FAS; 36 (6.5%) FAC; one (0.2%) SF; and five (0.9%) FSC. One hundred fourteen (22.2%) newborns had α2 3.7 Kb thalassemia, of whom 101 (19.7%) were heterozygous and 13 (2.5%) homozygous, showing statistical significance for hematological data between newborns with normal α genes and α2 3.7 Kb thalassemia carriers. The α2 4.2 Kb thalassemia was not found. Frequencies found in the present study confirm that hemoglobinopathies are a public health problem in Brazil, emphasizing the need for neonatal screening and genetic counseling programs.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2011-09-27T13:15:03Z No. of bitstreams: 1 32.pdf: 74190 bytes, checksum: 08432f5e87d18caf5654bad4e8b92f82 (MD5)Made available in DSpace on 2011-09-27T13:15:03Z (GMT). No. of bitstreams: 1 32.pdf: 74190 bytes, checksum: 08432f5e87d18caf5654bad4e8b92f82 (MD5) Previous issue date: 2005HemoglobinopathiesSickle Cell AnemiaThalassemiaNewborn InfantHemoglobinopatiasAnemia FalciformeTalassemiaRecém-NascidoHemoglobinopathies in newborns from Salvador, Bahia, Northeast BrazilCadernos de Saúde Públicainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINAL32.pdf32.pdfapplication/pdf74190https://repositorio.ufba.br/bitstream/ri/2890/1/32.pdf08432f5e87d18caf5654bad4e8b92f82MD51LICENSElicense.txtlicense.txttext/plain1918https://repositorio.ufba.br/bitstream/ri/2890/2/license.txt8001ac729b199e1997eb7192a36b973eMD52TEXT32.pdf.txt32.pdf.txtExtracted texttext/plain26646https://repositorio.ufba.br/bitstream/ri/2890/3/32.pdf.txt1f8191250067e0ece2c14d2a1072f5b1MD53ri/28902022-08-26 11:02:27.263oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-26T14:02:27Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil
dc.title.alternative.pt_BR.fl_str_mv Cadernos de Saúde Pública
title Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil
spellingShingle Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil
Adorno, Elisângela Vitória
Hemoglobinopathies
Sickle Cell Anemia
Thalassemia
Newborn Infant
Hemoglobinopatias
Anemia Falciforme
Talassemia
Recém-Nascido
title_short Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil
title_full Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil
title_fullStr Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil
title_full_unstemmed Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil
title_sort Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil
author Adorno, Elisângela Vitória
author_facet Adorno, Elisângela Vitória
Couto, Fábio David
Moura Neto, José Pereira de
Menezes, Joelma Figueiredo
Rêgo, Marco Antônio Vasconcelos
Reis, Mitermayer Galvão dos
Gonçalves, Marilda Souza
author_role author
author2 Couto, Fábio David
Moura Neto, José Pereira de
Menezes, Joelma Figueiredo
Rêgo, Marco Antônio Vasconcelos
Reis, Mitermayer Galvão dos
Gonçalves, Marilda Souza
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Adorno, Elisângela Vitória
Couto, Fábio David
Moura Neto, José Pereira de
Menezes, Joelma Figueiredo
Rêgo, Marco Antônio Vasconcelos
Reis, Mitermayer Galvão dos
Gonçalves, Marilda Souza
Adorno, Elisângela Vitória
Couto, Fábio David
Moura Neto, José Pereira de
Menezes, Joelma Figueiredo
Rêgo, Marco Antônio Vasconcelos
Reis, Mitermayer Galvão dos
Gonçalves, Marilda Souza
dc.subject.por.fl_str_mv Hemoglobinopathies
Sickle Cell Anemia
Thalassemia
Newborn Infant
Hemoglobinopatias
Anemia Falciforme
Talassemia
Recém-Nascido
topic Hemoglobinopathies
Sickle Cell Anemia
Thalassemia
Newborn Infant
Hemoglobinopatias
Anemia Falciforme
Talassemia
Recém-Nascido
description p. 292-298
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2011-09-27T13:15:03Z
dc.date.available.fl_str_mv 2011-09-27T13:15:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/2890
dc.identifier.issn.none.fl_str_mv 0102-311X
dc.identifier.number.pt_BR.fl_str_mv 21(1)
identifier_str_mv 0102-311X
21(1)
url http://www.repositorio.ufba.br/ri/handle/ri/2890
dc.language.iso.fl_str_mv eng
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dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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