Assessment of the serodiagnostic potential of nine novel proteins from Mycobacterium tuberculosis

Detalhes bibliográficos
Autor(a) principal: Moran, Alison J.
Data de Publicação: 2001
Outros Autores: Treit, Janice D., Whitney, Janice L., Abomoelak, Bassam, Sampaio, Diana Pedral, Badaró, Roberto José da Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7745
Resumo: Texto completo: acesso restrito. p. 31–36
id UFBA-2_541fbf1ebf04aabf24591f68271dc610
oai_identifier_str oai:repositorio.ufba.br:ri/7745
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Moran, Alison J.Treit, Janice D.Whitney, Janice L.Abomoelak, BassamSampaio, Diana PedralBadaró, Roberto José da SilvaMoran, Alison J.Treit, Janice D.Whitney, Janice L.Abomoelak, BassamSampaio, Diana PedralBadaró, Roberto José da Silva2013-01-04T12:49:34Z20010378-1097http://www.repositorio.ufba.br/ri/handle/ri/7745v. 198, n. 1Texto completo: acesso restrito. p. 31–36To identify antigens that would improve the accuracy of serological diagnosis of active tuberculosis, we cloned the genes encoding nine potentially immunogenic secreted or surface-associated proteins of Mycobacterium tuberculosis. Recombinant proteins were reacted with sera from HIV-negative individuals with extrapulmonary tuberculosis (EP-TB) or HIV-positive individuals with pulmonary tuberculosis (TBH). Specific and high level antibody responses were obtained for four recombinant proteins, of which antigen GST-822 was recognized by 60% of EP-TB and 42% of TBH and antigen MBP-506 was recognized by 45% of EP-TB and 61% of TBH. These results suggest that these proteins are strong candidates as subunits in a polyvalent serodiagnostic test.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-01-04T12:49:34Z No. of bitstreams: 1 Moran.pdf: 249721 bytes, checksum: 505259ca9f2e454644f98bd3b6efdd65 (MD5)Made available in DSpace on 2013-01-04T12:49:34Z (GMT). No. of bitstreams: 1 Moran.pdf: 249721 bytes, checksum: 505259ca9f2e454644f98bd3b6efdd65 (MD5) Previous issue date: 2001http://dx.doi.org/10.1016/S0378-1097(01)00115-Xreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASerodiagnosisTuberculosisAntigenAssessment of the serodiagnostic potential of nine novel proteins from Mycobacterium tuberculosisFEMS Microbiology Lettersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALMoran.pdfMoran.pdfapplication/pdf249721https://repositorio.ufba.br/bitstream/ri/7745/1/Moran.pdf505259ca9f2e454644f98bd3b6efdd65MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7745/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTMoran.pdf.txtMoran.pdf.txtExtracted texttext/plain25274https://repositorio.ufba.br/bitstream/ri/7745/3/Moran.pdf.txt8e0285a251162eb88d17a587354c786fMD53ri/77452022-07-05 14:03:38.172oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:38Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Assessment of the serodiagnostic potential of nine novel proteins from Mycobacterium tuberculosis
dc.title.alternative.pt_BR.fl_str_mv FEMS Microbiology Letters
title Assessment of the serodiagnostic potential of nine novel proteins from Mycobacterium tuberculosis
spellingShingle Assessment of the serodiagnostic potential of nine novel proteins from Mycobacterium tuberculosis
Moran, Alison J.
Serodiagnosis
Tuberculosis
Antigen
title_short Assessment of the serodiagnostic potential of nine novel proteins from Mycobacterium tuberculosis
title_full Assessment of the serodiagnostic potential of nine novel proteins from Mycobacterium tuberculosis
title_fullStr Assessment of the serodiagnostic potential of nine novel proteins from Mycobacterium tuberculosis
title_full_unstemmed Assessment of the serodiagnostic potential of nine novel proteins from Mycobacterium tuberculosis
title_sort Assessment of the serodiagnostic potential of nine novel proteins from Mycobacterium tuberculosis
author Moran, Alison J.
author_facet Moran, Alison J.
Treit, Janice D.
Whitney, Janice L.
Abomoelak, Bassam
Sampaio, Diana Pedral
Badaró, Roberto José da Silva
author_role author
author2 Treit, Janice D.
Whitney, Janice L.
Abomoelak, Bassam
Sampaio, Diana Pedral
Badaró, Roberto José da Silva
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Moran, Alison J.
Treit, Janice D.
Whitney, Janice L.
Abomoelak, Bassam
Sampaio, Diana Pedral
Badaró, Roberto José da Silva
Moran, Alison J.
Treit, Janice D.
Whitney, Janice L.
Abomoelak, Bassam
Sampaio, Diana Pedral
Badaró, Roberto José da Silva
dc.subject.por.fl_str_mv Serodiagnosis
Tuberculosis
Antigen
topic Serodiagnosis
Tuberculosis
Antigen
description Texto completo: acesso restrito. p. 31–36
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2013-01-04T12:49:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7745
dc.identifier.issn.none.fl_str_mv 0378-1097
dc.identifier.number.pt_BR.fl_str_mv v. 198, n. 1
identifier_str_mv 0378-1097
v. 198, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/7745
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/S0378-1097(01)00115-X
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/7745/1/Moran.pdf
https://repositorio.ufba.br/bitstream/ri/7745/2/license.txt
https://repositorio.ufba.br/bitstream/ri/7745/3/Moran.pdf.txt
bitstream.checksum.fl_str_mv 505259ca9f2e454644f98bd3b6efdd65
1b89a9a0548218172d7c829f87a0eab9
8e0285a251162eb88d17a587354c786f
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459414310486016

Registros relacionados