Reduction in diastolic blood pressure and cardiovascular mortality in nondiabetic hypertensive patients. a reanalysis of the HOT sudy

Detalhes bibliográficos
Autor(a) principal: Lopes, Antonio Alberto da Silva
Data de Publicação: 2001
Outros Autores: Andrade, Jadelson, Noblat, Antonio Carlos Beisl, Silveira, Marco Antonio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6276
Resumo: p.135-137
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spelling Lopes, Antonio Alberto da SilvaAndrade, JadelsonNoblat, Antonio Carlos BeislSilveira, Marco AntonioLopes, Antonio Alberto da SilvaAndrade, JadelsonNoblat, Antonio Carlos BeislSilveira, Marco Antonio2012-06-29T20:16:40Z2012-06-29T20:16:40Z2001-080066-782Xhttp://www.repositorio.ufba.br/ri/handle/ri/6276v. 77, n. 2p.135-137Objective - To use published Hypertension Optimal Treatment (HOT) Study data to evaluate changes in cardiovascular mortality in nondiabetic hypertensive patients according to the degree of reduction in their diastolic blood pressure. Methods - In the HOT Study, 18,700 patients from various centers were allocated at random to groups having different objectives of for diastolic blood pressure: ≤90 (n=6264); ≤85 n=6264); ≤80mmHg (n=6262). Felodipine was the basic drug used. Other antihypertensive drugs were administered in a sequential manner, aiming at the objectives of diastolic blood pressure reduction. Results - The group of nondiabetic hypertensive subjects with diastolic pressure ≤80mmHg had a cardiovascular mortality ratio of 4.1/1000 patients/year, 35.5% higher than the group with diastolic pressure ≤90mmHg (cardiovascular mortality ratio, 3.1/1000 patients/year). In contrast, diabetic patients allocated to the diastolic pressure objective group of ≤80mmHg had a 66.7% reduction in cardiovascular mortality (3.7/1000 patients/year) when compared with the diastolic pressure group of ≤90mmHg (cardiovascular mortality ratio, 11.1/1000 patients/year). Conclusion - The results indicate that in hypertensive diabetic patients reduction in diastolic blood pressure to levels ≤80mmHg decreases the risk of fatal cardiovascular events. It remains necessary to define the level of diastolic blood pressure ≤90mmHg at which maximal reduction in cardiovascular mortality is obtained for nondiabetics.Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-06-29T20:16:39Z No. of bitstreams: 1 Lopes, Antonio Alberto.pdf: 27721 bytes, checksum: 7bf85a571e3d49f96858103e79b81d7e (MD5)Made available in DSpace on 2012-06-29T20:16:40Z (GMT). No. of bitstreams: 1 Lopes, Antonio Alberto.pdf: 27721 bytes, checksum: 7bf85a571e3d49f96858103e79b81d7e (MD5) Previous issue date: 2001-08Rio de JaneiroArquivos Brasileiros de Cardiologiahttp://dx.doi.org/10.1590/S0066-782X2001000800004reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAArterial hypertensionHOT StudyDiabetes mellitusReduction in diastolic blood pressure and cardiovascular mortality in nondiabetic hypertensive patients. a reanalysis of the HOT sudyArq. Bras. 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dc.title.pt_BR.fl_str_mv Reduction in diastolic blood pressure and cardiovascular mortality in nondiabetic hypertensive patients. a reanalysis of the HOT sudy
dc.title.alternative.pt_BR.fl_str_mv Arq. Bras. Cardiol.
title Reduction in diastolic blood pressure and cardiovascular mortality in nondiabetic hypertensive patients. a reanalysis of the HOT sudy
spellingShingle Reduction in diastolic blood pressure and cardiovascular mortality in nondiabetic hypertensive patients. a reanalysis of the HOT sudy
Lopes, Antonio Alberto da Silva
Arterial hypertension
HOT Study
Diabetes mellitus
title_short Reduction in diastolic blood pressure and cardiovascular mortality in nondiabetic hypertensive patients. a reanalysis of the HOT sudy
title_full Reduction in diastolic blood pressure and cardiovascular mortality in nondiabetic hypertensive patients. a reanalysis of the HOT sudy
title_fullStr Reduction in diastolic blood pressure and cardiovascular mortality in nondiabetic hypertensive patients. a reanalysis of the HOT sudy
title_full_unstemmed Reduction in diastolic blood pressure and cardiovascular mortality in nondiabetic hypertensive patients. a reanalysis of the HOT sudy
title_sort Reduction in diastolic blood pressure and cardiovascular mortality in nondiabetic hypertensive patients. a reanalysis of the HOT sudy
author Lopes, Antonio Alberto da Silva
author_facet Lopes, Antonio Alberto da Silva
Andrade, Jadelson
Noblat, Antonio Carlos Beisl
Silveira, Marco Antonio
author_role author
author2 Andrade, Jadelson
Noblat, Antonio Carlos Beisl
Silveira, Marco Antonio
author2_role author
author
author
dc.contributor.author.fl_str_mv Lopes, Antonio Alberto da Silva
Andrade, Jadelson
Noblat, Antonio Carlos Beisl
Silveira, Marco Antonio
Lopes, Antonio Alberto da Silva
Andrade, Jadelson
Noblat, Antonio Carlos Beisl
Silveira, Marco Antonio
dc.subject.por.fl_str_mv Arterial hypertension
HOT Study
Diabetes mellitus
topic Arterial hypertension
HOT Study
Diabetes mellitus
description p.135-137
publishDate 2001
dc.date.issued.fl_str_mv 2001-08
dc.date.accessioned.fl_str_mv 2012-06-29T20:16:40Z
dc.date.available.fl_str_mv 2012-06-29T20:16:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6276
dc.identifier.issn.none.fl_str_mv 0066-782X
dc.identifier.number.pt_BR.fl_str_mv v. 77, n. 2
identifier_str_mv 0066-782X
v. 77, n. 2
url http://www.repositorio.ufba.br/ri/handle/ri/6276
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Arquivos Brasileiros de Cardiologia
publisher.none.fl_str_mv Arquivos Brasileiros de Cardiologia
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0066-782X2001000800004
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
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institution UFBA
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