Reduction in Diastolic Blood Pressure and Cardiovascular Mortality in Nondiabetic Hypertensive Patients. A Reanalysis of the HOT Study

Detalhes bibliográficos
Autor(a) principal: Lopes, Antonio Alberto da Silva
Data de Publicação: 2001
Outros Autores: Andrade, Jadelson, Noblat, Antonio Carlos Beisl, Silveira, Marco Antonio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16681
Resumo: p. 135-137
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spelling Lopes, Antonio Alberto da SilvaAndrade, JadelsonNoblat, Antonio Carlos BeislSilveira, Marco AntonioLopes, Antonio Alberto da SilvaAndrade, JadelsonNoblat, Antonio Carlos BeislSilveira, Marco Antonio2014-11-28T16:09:02Z2014-11-28T16:09:02Z20010066-782Xhttp://repositorio.ufba.br/ri/handle/ri/16681v. 77, n. 2p. 135-137OBJECTIVE: To use published Hypertension Optimal Treatment (HOT) Study data to evaluate changes in cardiovascular mortality in nondiabetic hypertensive patients according to the degree of reduction in their diastolic blood pressure. METHODS: In the HOT Study, 18,700 patients from various centers were allocated at random to groups having different objectives of for diastolic blood pressure: £90 (n=6264); £85 (n=6264); £80mmHg (n=6262). Felodipine was the basic drug used. Other antihypertensive drugs were administered in a sequential manner, aiming at the objectives of diastolic blood pressure reduction. RESULTS: The group of nondiabetic hypertensive subjects with diastolic pressure £80mmHg had a cardiovascular mortality ratio of 4.1/1000 patients/year, 35.5% higher than the group with diastolic pressure £90mmHg (cardiovascular mortality ratio, 3.1/1000 patients/year). In contrast, diabetic patients allocated to the diastolic pressure objective group of £80mmHg had a 66.7% reduction in cardiovascular mortality (3.7/1000 patients/year) when compared with the diastolic pressure group of £90mmHg (cardiovascular mortality ratio, 11.1/1000 patients/year). CONCLUSION: The results indicate that in hypertensive diabetic patients reduction in diastolic blood pressure to levels £80mmHg decreases the risk of fatal cardiovascular events. It remains necessary to define the level of diastolic blood pressure £90mmHg at which maximal reduction in cardiovascular mortality is obtained for nondiabetics.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-02-05T10:40:35Z No. of bitstreams: 1 Antonio Alberto Lopes.pdf: 27721 bytes, checksum: 7bf85a571e3d49f96858103e79b81d7e (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-11-28T16:09:02Z (GMT) No. of bitstreams: 1 Antonio Alberto Lopes.pdf: 27721 bytes, checksum: 7bf85a571e3d49f96858103e79b81d7e (MD5)Made available in DSpace on 2014-11-28T16:09:02Z (GMT). No. of bitstreams: 1 Antonio Alberto Lopes.pdf: 27721 bytes, checksum: 7bf85a571e3d49f96858103e79b81d7e (MD5) Previous issue date: 2001http://dx.doi.org/10.1590/S0066-782X2001000800004reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAArterial hypertensionHOT StudyDiabetes mellitusReduction in Diastolic Blood Pressure and Cardiovascular Mortality in Nondiabetic Hypertensive Patients. 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dc.title.pt_BR.fl_str_mv Reduction in Diastolic Blood Pressure and Cardiovascular Mortality in Nondiabetic Hypertensive Patients. A Reanalysis of the HOT Study
dc.title.alternative.pt_BR.fl_str_mv Arquivos Brasileiros de Cardiologia
title Reduction in Diastolic Blood Pressure and Cardiovascular Mortality in Nondiabetic Hypertensive Patients. A Reanalysis of the HOT Study
spellingShingle Reduction in Diastolic Blood Pressure and Cardiovascular Mortality in Nondiabetic Hypertensive Patients. A Reanalysis of the HOT Study
Lopes, Antonio Alberto da Silva
Arterial hypertension
HOT Study
Diabetes mellitus
title_short Reduction in Diastolic Blood Pressure and Cardiovascular Mortality in Nondiabetic Hypertensive Patients. A Reanalysis of the HOT Study
title_full Reduction in Diastolic Blood Pressure and Cardiovascular Mortality in Nondiabetic Hypertensive Patients. A Reanalysis of the HOT Study
title_fullStr Reduction in Diastolic Blood Pressure and Cardiovascular Mortality in Nondiabetic Hypertensive Patients. A Reanalysis of the HOT Study
title_full_unstemmed Reduction in Diastolic Blood Pressure and Cardiovascular Mortality in Nondiabetic Hypertensive Patients. A Reanalysis of the HOT Study
title_sort Reduction in Diastolic Blood Pressure and Cardiovascular Mortality in Nondiabetic Hypertensive Patients. A Reanalysis of the HOT Study
author Lopes, Antonio Alberto da Silva
author_facet Lopes, Antonio Alberto da Silva
Andrade, Jadelson
Noblat, Antonio Carlos Beisl
Silveira, Marco Antonio
author_role author
author2 Andrade, Jadelson
Noblat, Antonio Carlos Beisl
Silveira, Marco Antonio
author2_role author
author
author
dc.contributor.author.fl_str_mv Lopes, Antonio Alberto da Silva
Andrade, Jadelson
Noblat, Antonio Carlos Beisl
Silveira, Marco Antonio
Lopes, Antonio Alberto da Silva
Andrade, Jadelson
Noblat, Antonio Carlos Beisl
Silveira, Marco Antonio
dc.subject.por.fl_str_mv Arterial hypertension
HOT Study
Diabetes mellitus
topic Arterial hypertension
HOT Study
Diabetes mellitus
description p. 135-137
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2014-11-28T16:09:02Z
dc.date.available.fl_str_mv 2014-11-28T16:09:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16681
dc.identifier.issn.none.fl_str_mv 0066-782X
dc.identifier.number.pt_BR.fl_str_mv v. 77, n. 2
identifier_str_mv 0066-782X
v. 77, n. 2
url http://repositorio.ufba.br/ri/handle/ri/16681
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.country.fl_str_mv Brasil
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0066-782X2001000800004
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