Solid–Liquid Equilibrium of Substrates and Products of the Enzymatic Synthesis of Ampicillin

Detalhes bibliográficos
Autor(a) principal: Santana, Mônica Leila Portela de
Data de Publicação: 2010
Outros Autores: Ribeiro, Marcelo P. A., Leite, Geisa A., Giordano, Raquel L. C., Giordano, Roberto C., Silva, Silvana Mattedi e
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5775
Resumo: Acesso restrito: Texto completo. p. 1578-1583
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spelling Santana, Mônica Leila Portela deRibeiro, Marcelo P. A.Leite, Geisa A.Giordano, Raquel L. C.Giordano, Roberto C.Silva, Silvana Mattedi eSantana, Mônica Leila Portela deRibeiro, Marcelo P. A.Leite, Geisa A.Giordano, Raquel L. C.Giordano, Roberto C.Silva, Silvana Mattedi e2012-05-04T13:42:37Z20100001-1541http://www.repositorio.ufba.br/ri/handle/ri/5775v. 56, n. 6Acesso restrito: Texto completo. p. 1578-1583The solid–liquid equilibrium of precursors and products of the enzymatic synthesis of ampicillin (AMP) [6-aminopencillanic acid (6-APA) and D( )phenylglycine (PG)] was investigated at different temperatures (283–298 K) and pHs (5.5–7.5). Solubility data were obtained using an analytical methodology. Equilibrium dissociation constants were experimentally measured at several temperatures for AMP, 6-APA, PG, and D( )phenylglycine methyl ester. A model based on the simplified perturbed hard sphere theory proposed by Khoshkbarchi and Vera (Ind Eng Chem Res. 1996;35:4319- 4327) was fitted against solubility data. The model could describe the water solubility behavior for AMP and PG as function of pH and temperature, but a bias was observed when fitting the model to the solubility of 6-APA. VVC 2009 American Institute of Chemical Engineers AIChE J, 56: 1578–1583, 2010Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-05-04T13:42:37Z No. of bitstreams: 1 __onlinelibrary.wiley.co...aec75667bef8544092db7e6a8eaaf.pdf: 226622 bytes, checksum: 6d1f63adcc03a0b91912f65207977fbe (MD5)Made available in DSpace on 2012-05-04T13:42:37Z (GMT). No. of bitstreams: 1 __onlinelibrary.wiley.co...aec75667bef8544092db7e6a8eaaf.pdf: 226622 bytes, checksum: 6d1f63adcc03a0b91912f65207977fbe (MD5) Previous issue date: 2010DOI: 10.1002/aic.12082reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAB-lactam antibioticsGreen chemistrySolubilitySolid–liquid equilibriumThermodynamic modelingSolid–Liquid Equilibrium of Substrates and Products of the Enzymatic Synthesis of AmpicillinAiche Journalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL__onlinelibrary.wiley.co...aec75667bef8544092db7e6a8eaaf.pdf__onlinelibrary.wiley.co...aec75667bef8544092db7e6a8eaaf.pdfapplication/pdf226622https://repositorio.ufba.br/bitstream/ri/5775/1/__onlinelibrary.wiley.co...aec75667bef8544092db7e6a8eaaf.pdf6d1f63adcc03a0b91912f65207977fbeMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5775/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT__onlinelibrary.wiley.co...aec75667bef8544092db7e6a8eaaf.pdf.txt__onlinelibrary.wiley.co...aec75667bef8544092db7e6a8eaaf.pdf.txtExtracted texttext/plain25264https://repositorio.ufba.br/bitstream/ri/5775/3/__onlinelibrary.wiley.co...aec75667bef8544092db7e6a8eaaf.pdf.txt8eba8f853e8573531773e93679321eddMD53ri/57752022-07-05 14:03:13.57oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:13Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Solid–Liquid Equilibrium of Substrates and Products of the Enzymatic Synthesis of Ampicillin
dc.title.alternative.pt_BR.fl_str_mv Aiche Journal
title Solid–Liquid Equilibrium of Substrates and Products of the Enzymatic Synthesis of Ampicillin
spellingShingle Solid–Liquid Equilibrium of Substrates and Products of the Enzymatic Synthesis of Ampicillin
Santana, Mônica Leila Portela de
B-lactam antibiotics
Green chemistry
Solubility
Solid–liquid equilibrium
Thermodynamic modeling
title_short Solid–Liquid Equilibrium of Substrates and Products of the Enzymatic Synthesis of Ampicillin
title_full Solid–Liquid Equilibrium of Substrates and Products of the Enzymatic Synthesis of Ampicillin
title_fullStr Solid–Liquid Equilibrium of Substrates and Products of the Enzymatic Synthesis of Ampicillin
title_full_unstemmed Solid–Liquid Equilibrium of Substrates and Products of the Enzymatic Synthesis of Ampicillin
title_sort Solid–Liquid Equilibrium of Substrates and Products of the Enzymatic Synthesis of Ampicillin
author Santana, Mônica Leila Portela de
author_facet Santana, Mônica Leila Portela de
Ribeiro, Marcelo P. A.
Leite, Geisa A.
Giordano, Raquel L. C.
Giordano, Roberto C.
Silva, Silvana Mattedi e
author_role author
author2 Ribeiro, Marcelo P. A.
Leite, Geisa A.
Giordano, Raquel L. C.
Giordano, Roberto C.
Silva, Silvana Mattedi e
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Santana, Mônica Leila Portela de
Ribeiro, Marcelo P. A.
Leite, Geisa A.
Giordano, Raquel L. C.
Giordano, Roberto C.
Silva, Silvana Mattedi e
Santana, Mônica Leila Portela de
Ribeiro, Marcelo P. A.
Leite, Geisa A.
Giordano, Raquel L. C.
Giordano, Roberto C.
Silva, Silvana Mattedi e
dc.subject.por.fl_str_mv B-lactam antibiotics
Green chemistry
Solubility
Solid–liquid equilibrium
Thermodynamic modeling
topic B-lactam antibiotics
Green chemistry
Solubility
Solid–liquid equilibrium
Thermodynamic modeling
description Acesso restrito: Texto completo. p. 1578-1583
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2012-05-04T13:42:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5775
dc.identifier.issn.none.fl_str_mv 0001-1541
dc.identifier.number.pt_BR.fl_str_mv v. 56, n. 6
identifier_str_mv 0001-1541
v. 56, n. 6
url http://www.repositorio.ufba.br/ri/handle/ri/5775
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv DOI: 10.1002/aic.12082
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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