Variational calculus (optimal control) applied to the optimization of the enzymatic synthesis of ampicillin

Detalhes bibliográficos
Autor(a) principal: Ribeiro,Marcelo Perencin de Arruda
Data de Publicação: 2005
Outros Autores: Giordano,Roberto de Campos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000400003
Resumo: In this work, optimal control techniques were used to optimize the feed of reactants during the enzymatic synthesis of ampicillin in a semi-batch reactor. Simulation results showed that a semi-batch integrated reactor (with product crystallization) might achieve 88% 6-APA (6-aminepenicillanic acid) conversion and 92% of PGME (phenylglycine methyl ester) yield, with a productivity between 3.5 and 5.5 mM min-1.
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spelling Variational calculus (optimal control) applied to the optimization of the enzymatic synthesis of ampicillinSynthesis of beta-lactam antibioticsfed-batch reactor optimizationoptimal controlIn this work, optimal control techniques were used to optimize the feed of reactants during the enzymatic synthesis of ampicillin in a semi-batch reactor. Simulation results showed that a semi-batch integrated reactor (with product crystallization) might achieve 88% 6-APA (6-aminepenicillanic acid) conversion and 92% of PGME (phenylglycine methyl ester) yield, with a productivity between 3.5 and 5.5 mM min-1.Instituto de Tecnologia do Paraná - Tecpar2005-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000400003Brazilian Archives of Biology and Technology v.48 n.spe 2005reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132005000400003info:eu-repo/semantics/openAccessRibeiro,Marcelo Perencin de ArrudaGiordano,Roberto de Camposeng2005-08-15T00:00:00Zoai:scielo:S1516-89132005000400003Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2005-08-15T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Variational calculus (optimal control) applied to the optimization of the enzymatic synthesis of ampicillin
title Variational calculus (optimal control) applied to the optimization of the enzymatic synthesis of ampicillin
spellingShingle Variational calculus (optimal control) applied to the optimization of the enzymatic synthesis of ampicillin
Ribeiro,Marcelo Perencin de Arruda
Synthesis of beta-lactam antibiotics
fed-batch reactor optimization
optimal control
title_short Variational calculus (optimal control) applied to the optimization of the enzymatic synthesis of ampicillin
title_full Variational calculus (optimal control) applied to the optimization of the enzymatic synthesis of ampicillin
title_fullStr Variational calculus (optimal control) applied to the optimization of the enzymatic synthesis of ampicillin
title_full_unstemmed Variational calculus (optimal control) applied to the optimization of the enzymatic synthesis of ampicillin
title_sort Variational calculus (optimal control) applied to the optimization of the enzymatic synthesis of ampicillin
author Ribeiro,Marcelo Perencin de Arruda
author_facet Ribeiro,Marcelo Perencin de Arruda
Giordano,Roberto de Campos
author_role author
author2 Giordano,Roberto de Campos
author2_role author
dc.contributor.author.fl_str_mv Ribeiro,Marcelo Perencin de Arruda
Giordano,Roberto de Campos
dc.subject.por.fl_str_mv Synthesis of beta-lactam antibiotics
fed-batch reactor optimization
optimal control
topic Synthesis of beta-lactam antibiotics
fed-batch reactor optimization
optimal control
description In this work, optimal control techniques were used to optimize the feed of reactants during the enzymatic synthesis of ampicillin in a semi-batch reactor. Simulation results showed that a semi-batch integrated reactor (with product crystallization) might achieve 88% 6-APA (6-aminepenicillanic acid) conversion and 92% of PGME (phenylglycine methyl ester) yield, with a productivity between 3.5 and 5.5 mM min-1.
publishDate 2005
dc.date.none.fl_str_mv 2005-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000400003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000400003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132005000400003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.48 n.spe 2005
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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