Serum levels of Th17 associated cytokines in chronic hepatitis C virus infection

Detalhes bibliográficos
Autor(a) principal: Sousa, Gabriel Menezes de
Data de Publicação: 2012
Outros Autores: Oliveira, Isabela S., Andrade, Luis Jesuino de Oliveira, Atta, Maria Luiza Brito de Sousa, Paraná, Raymundo, Atta, Ajax Mercês
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16452
Resumo: Texto completo: acesso restrito. p. 138–142
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spelling Sousa, Gabriel Menezes deOliveira, Isabela S.Andrade, Luis Jesuino de OliveiraAtta, Maria Luiza Brito de SousaParaná, RaymundoAtta, Ajax MercêsSousa, Gabriel Menezes deOliveira, Isabela S.Andrade, Luis Jesuino de OliveiraAtta, Maria Luiza Brito de SousaParaná, RaymundoAtta, Ajax Mercês2014-10-21T16:56:46Z20121043-4666http://repositorio.ufba.br/ri/handle/ri/16452v. 60, n. 1Texto completo: acesso restrito. p. 138–142The Th17-mediated immune response was investigated in patients chronically infected with hepatitis C virus (HCV) by determining the serum levels of the cytokines involved in the induction of the Th17 response (TGF-β and IL-6), the cytokines produced by Th17 cells (IL-17A, IL-17F and IL-22) and the cytokines whose production is stimulated by Th17 lymphocytes (IL-8 and GM-CSF). We investigated the relationships among the levels of these cytokines by assessing clinical findings, liver histology and viremia. Sixty untreated patients and 28 healthy individuals were included in the study. Cytokine levels were determined using ELISA. Differences between HCV and control groups were identified in the median levels of IL-17F (controls = 172.4 pg/mL; HCV = 96.8 pg/mL, p < 0.001) and IL-8 (controls = 30.1 pg/mL; HCV = 18.1 pg/mL, p < 0.05). IL-6 levels were higher in patients presenting moderate liver necroinflammation than in patients with mild or no liver necroinflammation (p < 0.05). IL-17F levels were increased in patients that had increased ALT levels. Additionally, a strong positive correlation was observed between IL-17F and IL-22 levels in the two groups investigated, and the IL-17F/IL-22 ratio was lower in the patients infected with HCV (p < 0.0001). Patients with low HCV viral loads had higher median levels of IL-8 (32.5 pg/mL) than did patients with high HCV loads (16.7 pg/mL, p < 0.05). These results suggest that in chronic hepatitis C infection, IL-17F and IL-8 could be associated with the control of liver injury and infection, respectively.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-05-20T13:21:08Z No. of bitstreams: 1 Raymundo Paraná.pdf: 250003 bytes, checksum: 5610740f44df4a9271d54b9235020ac6 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-10-21T16:56:46Z (GMT) No. of bitstreams: 1 Raymundo Paraná.pdf: 250003 bytes, checksum: 5610740f44df4a9271d54b9235020ac6 (MD5)Made available in DSpace on 2014-10-21T16:56:46Z (GMT). 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dc.title.pt_BR.fl_str_mv Serum levels of Th17 associated cytokines in chronic hepatitis C virus infection
dc.title.alternative.pt_BR.fl_str_mv Cytokine
title Serum levels of Th17 associated cytokines in chronic hepatitis C virus infection
spellingShingle Serum levels of Th17 associated cytokines in chronic hepatitis C virus infection
Sousa, Gabriel Menezes de
Hepatitis C
Th17
Cytokine
Liver histology
Viral load
title_short Serum levels of Th17 associated cytokines in chronic hepatitis C virus infection
title_full Serum levels of Th17 associated cytokines in chronic hepatitis C virus infection
title_fullStr Serum levels of Th17 associated cytokines in chronic hepatitis C virus infection
title_full_unstemmed Serum levels of Th17 associated cytokines in chronic hepatitis C virus infection
title_sort Serum levels of Th17 associated cytokines in chronic hepatitis C virus infection
author Sousa, Gabriel Menezes de
author_facet Sousa, Gabriel Menezes de
Oliveira, Isabela S.
Andrade, Luis Jesuino de Oliveira
Atta, Maria Luiza Brito de Sousa
Paraná, Raymundo
Atta, Ajax Mercês
author_role author
author2 Oliveira, Isabela S.
Andrade, Luis Jesuino de Oliveira
Atta, Maria Luiza Brito de Sousa
Paraná, Raymundo
Atta, Ajax Mercês
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Sousa, Gabriel Menezes de
Oliveira, Isabela S.
Andrade, Luis Jesuino de Oliveira
Atta, Maria Luiza Brito de Sousa
Paraná, Raymundo
Atta, Ajax Mercês
Sousa, Gabriel Menezes de
Oliveira, Isabela S.
Andrade, Luis Jesuino de Oliveira
Atta, Maria Luiza Brito de Sousa
Paraná, Raymundo
Atta, Ajax Mercês
dc.subject.por.fl_str_mv Hepatitis C
Th17
Cytokine
Liver histology
Viral load
topic Hepatitis C
Th17
Cytokine
Liver histology
Viral load
description Texto completo: acesso restrito. p. 138–142
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-10-21T16:56:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16452
dc.identifier.issn.none.fl_str_mv 1043-4666
dc.identifier.number.pt_BR.fl_str_mv v. 60, n. 1
identifier_str_mv 1043-4666
v. 60, n. 1
url http://repositorio.ufba.br/ri/handle/ri/16452
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.cyto.2012.06.003
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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