HIV-1 resistance testing influences treatment decision-making

Detalhes bibliográficos
Autor(a) principal: Diaz, Ricardo Sobhie
Data de Publicação: 2010
Outros Autores: Sucupira, Maria Cecilia A, Vergara, Tania RC, Brites, Carlos, Bianco, Rosana Del, Bonasser Filho, Francisco, Colares, Geova Keny B
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5647
Resumo: Acesso restrito: Texto completo. p. 489-494.
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spelling Diaz, Ricardo SobhieSucupira, Maria Cecilia AVergara, Tania RCBrites, CarlosBianco, Rosana DelBonasser Filho, FranciscoColares, Geova Keny BDiaz, Ricardo SobhieSucupira, Maria Cecilia AVergara, Tania RCBrites, CarlosBianco, Rosana DelBonasser Filho, FranciscoColares, Geova Keny B2012-04-19T12:33:56Z20101413-8670http://www.repositorio.ufba.br/ri/handle/ri/5647v. 14, n. 5Acesso restrito: Texto completo. p. 489-494.Objective: To investigates how the use of HIV-1 resistance tests infl uences physician decision-making. Methods: Ten experienced reference physicians from the Brazilian Network for Drug Resistance each received ten patients’ case histories. The selected patients had experienced at least two virological failures. First, reference physicians were asked to empirically select a new regimen for each patient. Second, after genotype report (ViroSeq 2.6) was provided, and physicians were again asked to select a new regimen considering this additional information. Finally, they were asked to select a regimen after receiving a virtual phenotype result (vircoTYPE 3.9.00). Results: In 79% of the cases, physicians changed their empirical choice of regimen after receiving the genotype report, resulting in an increase in the mean number of active drugs from 1.8 to 2.2 (p = 0.0003), while the average number of drugs/regimen remained at 4.0. After receipt of the virtual phenotype report, additional changes were made in 75% of the patient cases, resulting in an increase in the number of active drugs to 2.8 (p < 0.0001), while the average number of drugs/ regimen remained at 4.0. After receipt of the genotype report, 48% of the changes were in NRTIs, 29% were in NNRTIs and 60% were in PIs; after consideration of the virtual phenotype, 61%, 10% and 49% of the changes, respectively, were in these categories of drugs. Fourteen percent of the physicians rated the genotype report as “extremely useful”, whereas 34% rated the subsequent virtual phenotype report as “extremely useful” (p = 0.0003). Conclusions: Resistance testing has a signifi cant impact on physicians’ choices of antiretroviral salvage therapies, and it promotes the selection of more active drugs.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-04-19T12:33:56Z No. of bitstreams: 1 __www.scielo.br_pdf_bjid_v14n5_v14n5a11.pdf: 250392 bytes, checksum: 87c0cb8c22fe470219a8e1d807a327b6 (MD5)Made available in DSpace on 2012-04-19T12:33:56Z (GMT). No. of bitstreams: 1 __www.scielo.br_pdf_bjid_v14n5_v14n5a11.pdf: 250392 bytes, checksum: 87c0cb8c22fe470219a8e1d807a327b6 (MD5) Previous issue date: 2010Salvadorhttp://dx.doi.org/10.1590/S1413-86702010000500011reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAGenotypeVirtual phenotypeAntiretroviral resistanceBrazilHIV-1 resistance testing influences treatment decision-makingBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL__www.scielo.br_pdf_bjid_v14n5_v14n5a11.pdf__www.scielo.br_pdf_bjid_v14n5_v14n5a11.pdfapplication/pdf250392https://repositorio.ufba.br/bitstream/ri/5647/1/__www.scielo.br_pdf_bjid_v14n5_v14n5a11.pdf87c0cb8c22fe470219a8e1d807a327b6MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5647/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT__www.scielo.br_pdf_bjid_v14n5_v14n5a11.pdf.txt__www.scielo.br_pdf_bjid_v14n5_v14n5a11.pdf.txtExtracted texttext/plain27229https://repositorio.ufba.br/bitstream/ri/5647/3/__www.scielo.br_pdf_bjid_v14n5_v14n5a11.pdf.txt7dcae46cf08cdc4b036e4038ff78aa3eMD53ri/56472022-07-05 14:03:30.679oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:30Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv HIV-1 resistance testing influences treatment decision-making
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Infectious Diseases
title HIV-1 resistance testing influences treatment decision-making
spellingShingle HIV-1 resistance testing influences treatment decision-making
Diaz, Ricardo Sobhie
Genotype
Virtual phenotype
Antiretroviral resistance
Brazil
title_short HIV-1 resistance testing influences treatment decision-making
title_full HIV-1 resistance testing influences treatment decision-making
title_fullStr HIV-1 resistance testing influences treatment decision-making
title_full_unstemmed HIV-1 resistance testing influences treatment decision-making
title_sort HIV-1 resistance testing influences treatment decision-making
author Diaz, Ricardo Sobhie
author_facet Diaz, Ricardo Sobhie
Sucupira, Maria Cecilia A
Vergara, Tania RC
Brites, Carlos
Bianco, Rosana Del
Bonasser Filho, Francisco
Colares, Geova Keny B
author_role author
author2 Sucupira, Maria Cecilia A
Vergara, Tania RC
Brites, Carlos
Bianco, Rosana Del
Bonasser Filho, Francisco
Colares, Geova Keny B
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Diaz, Ricardo Sobhie
Sucupira, Maria Cecilia A
Vergara, Tania RC
Brites, Carlos
Bianco, Rosana Del
Bonasser Filho, Francisco
Colares, Geova Keny B
Diaz, Ricardo Sobhie
Sucupira, Maria Cecilia A
Vergara, Tania RC
Brites, Carlos
Bianco, Rosana Del
Bonasser Filho, Francisco
Colares, Geova Keny B
dc.subject.por.fl_str_mv Genotype
Virtual phenotype
Antiretroviral resistance
Brazil
topic Genotype
Virtual phenotype
Antiretroviral resistance
Brazil
description Acesso restrito: Texto completo. p. 489-494.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2012-04-19T12:33:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5647
dc.identifier.issn.none.fl_str_mv 1413-8670
dc.identifier.number.pt_BR.fl_str_mv v. 14, n. 5
identifier_str_mv 1413-8670
v. 14, n. 5
url http://www.repositorio.ufba.br/ri/handle/ri/5647
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S1413-86702010000500011
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