Primary resistance of HIV to antiretrovirals among individuals recently diagnosed at voluntary counselling and testing centres in the metropolitan region of Recife, Pernambuco
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/7115 http://dx.doi.org/10.1590/S0074-02762012000400002 |
Resumo: | Determining the prevalence and type of antiretroviral (ARV) resistance among ARV-naïve individuals is important to assess the potential responses of these individuals to first-line regimens. The prevalence of primary resistance and the occurrence of recent infections among individuals with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) were identified among recently diagnosed patients at five sexually transmitted disease/AIDS testing and counselling centres in the metropolitan region of Recife (RMR), Pernambuco, Brazil, between 2007-2009. One-hundred and eight samples were analysed using the Calypte® BED assay. Males predominated (56%), as did patients aged 31-50 years. Twenty-three percent presented evidence of a recent HIV infection. The median CD4+ T lymphocyte count was 408 cells/mm³ and the median viral load was 3.683 copies/mL. The prevalence of primary resistance was 4.6% (confidence interval 95% = 1-8.2%) based on criteria that excluded common polymorphisms in accordance with the surveillance drug resistance mutation criteria. The prevalence of resistance to non-nucleoside reverse transcriptase, nucleoside/nucleotide reverse transcriptase and protease inhibitors were 3.8%, 1.5% and 0.8%, respectively. Fifty-seven percent of strains were from clade B, 37.7% were clade F and 3.1% were clade C; there were no statistically significant differences with respect to resistance between clades. Recent infection tended to be more common in men (p = 0.06) and in municipalities in the south of the RMR (Jaboatão dos Guararapes and Cabo de Santo Agostinho) (p = 0.046). The high prevalence of recent infection and the high prevalence of non-B strains in this poor Brazilian region merit further attention. |
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Cavalcanti, Ana Maria SalustianoBrito, Ana Maria deSalustiano, Daniela MedeirosLima, Kledoaldo Oliveira deSilva, Sirleide Pereira daDiaz, Ricardo Sobhie [UNIFESP]Lacerda, Heloisa RamosLaboratório Central de Saúde Pública de Pernambuco Setor de VirologiaUniversidade Federal de Pernambuco Programa de Pós-Graduação em Medicina TropicalFiocruz Centro de Pesquisa Aggeu MagalhãesCentro de Testagem e Aconselhamento Herbert de SouzaUniversidade Federal de São Paulo (UNIFESP)2015-06-14T13:44:43Z2015-06-14T13:44:43Z2012-06-01Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 107, n. 4, p. 450-457, 2012.0074-0276http://repositorio.unifesp.br/handle/11600/7115http://dx.doi.org/10.1590/S0074-02762012000400002S0074-02762012000400002.pdfS0074-0276201200040000210.1590/S0074-02762012000400002WOS:000304853500002Determining the prevalence and type of antiretroviral (ARV) resistance among ARV-naïve individuals is important to assess the potential responses of these individuals to first-line regimens. The prevalence of primary resistance and the occurrence of recent infections among individuals with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) were identified among recently diagnosed patients at five sexually transmitted disease/AIDS testing and counselling centres in the metropolitan region of Recife (RMR), Pernambuco, Brazil, between 2007-2009. One-hundred and eight samples were analysed using the Calypte® BED assay. Males predominated (56%), as did patients aged 31-50 years. Twenty-three percent presented evidence of a recent HIV infection. The median CD4+ T lymphocyte count was 408 cells/mm³ and the median viral load was 3.683 copies/mL. The prevalence of primary resistance was 4.6% (confidence interval 95% = 1-8.2%) based on criteria that excluded common polymorphisms in accordance with the surveillance drug resistance mutation criteria. The prevalence of resistance to non-nucleoside reverse transcriptase, nucleoside/nucleotide reverse transcriptase and protease inhibitors were 3.8%, 1.5% and 0.8%, respectively. Fifty-seven percent of strains were from clade B, 37.7% were clade F and 3.1% were clade C; there were no statistically significant differences with respect to resistance between clades. Recent infection tended to be more common in men (p = 0.06) and in municipalities in the south of the RMR (Jaboatão dos Guararapes and Cabo de Santo Agostinho) (p = 0.046). The high prevalence of recent infection and the high prevalence of non-B strains in this poor Brazilian region merit further attention.Laboratório Central de Saúde Pública de Pernambuco Setor de VirologiaUniversidade Federal de Pernambuco Programa de Pós-Graduação em Medicina TropicalFiocruz Centro de Pesquisa Aggeu MagalhãesCentro de Testagem e Aconselhamento Herbert de SouzaUniversidade Federal de São Paulo (UNIFESP) Laboratório de RetrovirologiaUNIFESP, Laboratório de RetrovirologiaSciELO450-457engInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruztransmitted antiretroviral resistanceHIV subtypeBrazilrecent HIV infectionPrimary resistance of HIV to antiretrovirals among individuals recently diagnosed at voluntary counselling and testing centres in the metropolitan region of Recife, Pernambucoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0074-02762012000400002.pdfapplication/pdf417892${dspace.ui.url}/bitstream/11600/7115/1/S0074-02762012000400002.pdf7b04681d83b94369c9f223098b3bbaf0MD51open accessTEXTS0074-02762012000400002.pdf.txtS0074-02762012000400002.pdf.txtExtracted texttext/plain36539${dspace.ui.url}/bitstream/11600/7115/2/S0074-02762012000400002.pdf.txt5bf364287b358312fe2f421488db7827MD52open access11600/71152021-10-05 21:43:44.037open accessoai:repositorio.unifesp.br:11600/7115Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-10-06T00:43:44Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Primary resistance of HIV to antiretrovirals among individuals recently diagnosed at voluntary counselling and testing centres in the metropolitan region of Recife, Pernambuco |
title |
Primary resistance of HIV to antiretrovirals among individuals recently diagnosed at voluntary counselling and testing centres in the metropolitan region of Recife, Pernambuco |
spellingShingle |
Primary resistance of HIV to antiretrovirals among individuals recently diagnosed at voluntary counselling and testing centres in the metropolitan region of Recife, Pernambuco Cavalcanti, Ana Maria Salustiano transmitted antiretroviral resistance HIV subtype Brazil recent HIV infection |
title_short |
Primary resistance of HIV to antiretrovirals among individuals recently diagnosed at voluntary counselling and testing centres in the metropolitan region of Recife, Pernambuco |
title_full |
Primary resistance of HIV to antiretrovirals among individuals recently diagnosed at voluntary counselling and testing centres in the metropolitan region of Recife, Pernambuco |
title_fullStr |
Primary resistance of HIV to antiretrovirals among individuals recently diagnosed at voluntary counselling and testing centres in the metropolitan region of Recife, Pernambuco |
title_full_unstemmed |
Primary resistance of HIV to antiretrovirals among individuals recently diagnosed at voluntary counselling and testing centres in the metropolitan region of Recife, Pernambuco |
title_sort |
Primary resistance of HIV to antiretrovirals among individuals recently diagnosed at voluntary counselling and testing centres in the metropolitan region of Recife, Pernambuco |
author |
Cavalcanti, Ana Maria Salustiano |
author_facet |
Cavalcanti, Ana Maria Salustiano Brito, Ana Maria de Salustiano, Daniela Medeiros Lima, Kledoaldo Oliveira de Silva, Sirleide Pereira da Diaz, Ricardo Sobhie [UNIFESP] Lacerda, Heloisa Ramos |
author_role |
author |
author2 |
Brito, Ana Maria de Salustiano, Daniela Medeiros Lima, Kledoaldo Oliveira de Silva, Sirleide Pereira da Diaz, Ricardo Sobhie [UNIFESP] Lacerda, Heloisa Ramos |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Laboratório Central de Saúde Pública de Pernambuco Setor de Virologia Universidade Federal de Pernambuco Programa de Pós-Graduação em Medicina Tropical Fiocruz Centro de Pesquisa Aggeu Magalhães Centro de Testagem e Aconselhamento Herbert de Souza Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Cavalcanti, Ana Maria Salustiano Brito, Ana Maria de Salustiano, Daniela Medeiros Lima, Kledoaldo Oliveira de Silva, Sirleide Pereira da Diaz, Ricardo Sobhie [UNIFESP] Lacerda, Heloisa Ramos |
dc.subject.eng.fl_str_mv |
transmitted antiretroviral resistance HIV subtype Brazil recent HIV infection |
topic |
transmitted antiretroviral resistance HIV subtype Brazil recent HIV infection |
description |
Determining the prevalence and type of antiretroviral (ARV) resistance among ARV-naïve individuals is important to assess the potential responses of these individuals to first-line regimens. The prevalence of primary resistance and the occurrence of recent infections among individuals with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) were identified among recently diagnosed patients at five sexually transmitted disease/AIDS testing and counselling centres in the metropolitan region of Recife (RMR), Pernambuco, Brazil, between 2007-2009. One-hundred and eight samples were analysed using the Calypte® BED assay. Males predominated (56%), as did patients aged 31-50 years. Twenty-three percent presented evidence of a recent HIV infection. The median CD4+ T lymphocyte count was 408 cells/mm³ and the median viral load was 3.683 copies/mL. The prevalence of primary resistance was 4.6% (confidence interval 95% = 1-8.2%) based on criteria that excluded common polymorphisms in accordance with the surveillance drug resistance mutation criteria. The prevalence of resistance to non-nucleoside reverse transcriptase, nucleoside/nucleotide reverse transcriptase and protease inhibitors were 3.8%, 1.5% and 0.8%, respectively. Fifty-seven percent of strains were from clade B, 37.7% were clade F and 3.1% were clade C; there were no statistically significant differences with respect to resistance between clades. Recent infection tended to be more common in men (p = 0.06) and in municipalities in the south of the RMR (Jaboatão dos Guararapes and Cabo de Santo Agostinho) (p = 0.046). The high prevalence of recent infection and the high prevalence of non-B strains in this poor Brazilian region merit further attention. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-06-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:44:43Z |
dc.date.available.fl_str_mv |
2015-06-14T13:44:43Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 107, n. 4, p. 450-457, 2012. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/7115 http://dx.doi.org/10.1590/S0074-02762012000400002 |
dc.identifier.issn.none.fl_str_mv |
0074-0276 |
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S0074-02762012000400002.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0074-02762012000400002 |
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10.1590/S0074-02762012000400002 |
dc.identifier.wos.none.fl_str_mv |
WOS:000304853500002 |
identifier_str_mv |
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 107, n. 4, p. 450-457, 2012. 0074-0276 S0074-02762012000400002.pdf S0074-02762012000400002 10.1590/S0074-02762012000400002 WOS:000304853500002 |
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http://repositorio.unifesp.br/handle/11600/7115 http://dx.doi.org/10.1590/S0074-02762012000400002 |
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eng |
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Memórias do Instituto Oswaldo Cruz |
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450-457 |
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Instituto Oswaldo Cruz, Ministério da Saúde |
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Instituto Oswaldo Cruz, Ministério da Saúde |
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