Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/12772 |
Resumo: | Texto completo: acesso restrito.p. 713-719 |
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Gao, PeisongShimizu, KenichiGrant, Audrey V.Rafaels, Nicholas M.Zhou, Lin-FuHudson, Sherry A.Konno, SatoshiZimmermann, NivesAraujo, MariaPonte, Eduardo VieiraCruz Filho, Álvaro Augusto Souza daGao, PeisongShimizu, KenichiGrant, Audrey V.Rafaels, Nicholas M.Zhou, Lin-FuHudson, Sherry A.Konno, SatoshiZimmermann, NivesAraujo, MariaPonte, Eduardo VieiraCruz Filho, Álvaro Augusto Souza da2013-08-28T17:04:07Z20101018-4813http://www.repositorio.ufba.br/ri/handle/ri/12772European Journal of Human GeneticsTexto completo: acesso restrito.p. 713-719Sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) promotes the apoptosis of eosinophils and inhibits FcεRI-dependent mediator release from mast cells. We investigated the genetic association between sequence variants in Siglec-8 and diagnosis of asthma, total levels of serum IgE (tIgE), and diagnosis of eosinophilic esophagitis (EE) in diverse populations. The effect of sequence variants on Siglec-8 glycan ligand-binding activity was also examined. Significant association with asthma was observed for SNP rs36498 (odds ratios (OR), 0.69, P=8.8 × 10−5) among African Americans and for SNP rs10409962 (Ser/Pro) in the Japanese population (OR, 0.69, P=0.019). Supporting this finding, we observed association between SNP rs36498 and current asthma among Brazilian families (P=0.013). Significant association with tIgE was observed for SNP rs6509541 among African Americans (P=0.016), and replicated among the Brazilian families (P=0.02). In contrast, no association was observed with EE in Caucasians. By using a synthetic polymer decorated with 6′-sulfo-sLex, a known Siglec-8 glycan ligand, we did not find any differences between the ligand-binding activity of HEK293 cells stably transfected with the rs10409962 risk allele or the WT allele. However, our association results suggest that the Siglec8 gene may be a susceptibility locus for asthma.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-08-28T12:21:17Z No. of bitstreams: 1 ejhg2009239a.pdf: 524288 bytes, checksum: c7f749bf64ee8f577afa4b0ff0273840 (MD5)Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-08-28T17:04:07Z (GMT) No. of bitstreams: 1 ejhg2009239a.pdf: 524288 bytes, checksum: c7f749bf64ee8f577afa4b0ff0273840 (MD5)Made available in DSpace on 2013-08-28T17:04:07Z (GMT). No. of bitstreams: 1 ejhg2009239a.pdf: 524288 bytes, checksum: c7f749bf64ee8f577afa4b0ff0273840 (MD5) Previous issue date: 2010http://dx.doi.org/10.1038/ejhg.2009.239reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASialic acid-binding immunoglobulin-like lectin-8 (Siglec8)PolymorphismsAsthmaEosinophilic esophagitisPolymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthmaEuropean Journal of Human Geneticsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALejhg2009239a.pdfejhg2009239a.pdfapplication/pdf524288https://repositorio.ufba.br/bitstream/ri/12772/1/ejhg2009239a.pdfc7f749bf64ee8f577afa4b0ff0273840MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12772/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTejhg2009239a.pdf.txtejhg2009239a.pdf.txtExtracted texttext/plain44983https://repositorio.ufba.br/bitstream/ri/12772/3/ejhg2009239a.pdf.txtc58d0c01e9fc2f8a3b71dcba86a398e0MD53ri/127722022-07-05 14:02:49.109oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:49Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma |
| dc.title.alternative.pt_BR.fl_str_mv |
European Journal of Human Genetics |
| title |
Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma |
| spellingShingle |
Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma Gao, Peisong Sialic acid-binding immunoglobulin-like lectin-8 (Siglec8) Polymorphisms Asthma Eosinophilic esophagitis |
| title_short |
Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma |
| title_full |
Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma |
| title_fullStr |
Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma |
| title_full_unstemmed |
Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma |
| title_sort |
Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma |
| author |
Gao, Peisong |
| author_facet |
Gao, Peisong Shimizu, Kenichi Grant, Audrey V. Rafaels, Nicholas M. Zhou, Lin-Fu Hudson, Sherry A. Konno, Satoshi Zimmermann, Nives Araujo, Maria Ponte, Eduardo Vieira Cruz Filho, Álvaro Augusto Souza da |
| author_role |
author |
| author2 |
Shimizu, Kenichi Grant, Audrey V. Rafaels, Nicholas M. Zhou, Lin-Fu Hudson, Sherry A. Konno, Satoshi Zimmermann, Nives Araujo, Maria Ponte, Eduardo Vieira Cruz Filho, Álvaro Augusto Souza da |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gao, Peisong Shimizu, Kenichi Grant, Audrey V. Rafaels, Nicholas M. Zhou, Lin-Fu Hudson, Sherry A. Konno, Satoshi Zimmermann, Nives Araujo, Maria Ponte, Eduardo Vieira Cruz Filho, Álvaro Augusto Souza da Gao, Peisong Shimizu, Kenichi Grant, Audrey V. Rafaels, Nicholas M. Zhou, Lin-Fu Hudson, Sherry A. Konno, Satoshi Zimmermann, Nives Araujo, Maria Ponte, Eduardo Vieira Cruz Filho, Álvaro Augusto Souza da |
| dc.subject.por.fl_str_mv |
Sialic acid-binding immunoglobulin-like lectin-8 (Siglec8) Polymorphisms Asthma Eosinophilic esophagitis |
| topic |
Sialic acid-binding immunoglobulin-like lectin-8 (Siglec8) Polymorphisms Asthma Eosinophilic esophagitis |
| description |
Texto completo: acesso restrito.p. 713-719 |
| publishDate |
2010 |
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2010 |
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2013-08-28T17:04:07Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://www.repositorio.ufba.br/ri/handle/ri/12772 |
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1018-4813 |
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European Journal of Human Genetics |
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1018-4813 European Journal of Human Genetics |
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http://www.repositorio.ufba.br/ri/handle/ri/12772 |
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http://dx.doi.org/10.1038/ejhg.2009.239 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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