Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma

Detalhes bibliográficos
Autor(a) principal: Gao, Peisong
Data de Publicação: 2010
Outros Autores: Shimizu, Kenichi, Grant, Audrey V., Rafaels, Nicholas M., Zhou, Lin-Fu, Hudson, Sherry A., Konno, Satoshi, Zimmermann, Nives, Araujo, Maria, Ponte, Eduardo Vieira, Cruz Filho, Álvaro Augusto Souza da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12772
Resumo: Texto completo: acesso restrito.p. 713-719
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spelling Gao, PeisongShimizu, KenichiGrant, Audrey V.Rafaels, Nicholas M.Zhou, Lin-FuHudson, Sherry A.Konno, SatoshiZimmermann, NivesAraujo, MariaPonte, Eduardo VieiraCruz Filho, Álvaro Augusto Souza daGao, PeisongShimizu, KenichiGrant, Audrey V.Rafaels, Nicholas M.Zhou, Lin-FuHudson, Sherry A.Konno, SatoshiZimmermann, NivesAraujo, MariaPonte, Eduardo VieiraCruz Filho, Álvaro Augusto Souza da2013-08-28T17:04:07Z20101018-4813http://www.repositorio.ufba.br/ri/handle/ri/12772European Journal of Human GeneticsTexto completo: acesso restrito.p. 713-719Sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) promotes the apoptosis of eosinophils and inhibits FcεRI-dependent mediator release from mast cells. We investigated the genetic association between sequence variants in Siglec-8 and diagnosis of asthma, total levels of serum IgE (tIgE), and diagnosis of eosinophilic esophagitis (EE) in diverse populations. The effect of sequence variants on Siglec-8 glycan ligand-binding activity was also examined. Significant association with asthma was observed for SNP rs36498 (odds ratios (OR), 0.69, P=8.8 × 10−5) among African Americans and for SNP rs10409962 (Ser/Pro) in the Japanese population (OR, 0.69, P=0.019). Supporting this finding, we observed association between SNP rs36498 and current asthma among Brazilian families (P=0.013). Significant association with tIgE was observed for SNP rs6509541 among African Americans (P=0.016), and replicated among the Brazilian families (P=0.02). In contrast, no association was observed with EE in Caucasians. By using a synthetic polymer decorated with 6′-sulfo-sLex, a known Siglec-8 glycan ligand, we did not find any differences between the ligand-binding activity of HEK293 cells stably transfected with the rs10409962 risk allele or the WT allele. However, our association results suggest that the Siglec8 gene may be a susceptibility locus for asthma.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-08-28T12:21:17Z No. of bitstreams: 1 ejhg2009239a.pdf: 524288 bytes, checksum: c7f749bf64ee8f577afa4b0ff0273840 (MD5)Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-08-28T17:04:07Z (GMT) No. of bitstreams: 1 ejhg2009239a.pdf: 524288 bytes, checksum: c7f749bf64ee8f577afa4b0ff0273840 (MD5)Made available in DSpace on 2013-08-28T17:04:07Z (GMT). No. of bitstreams: 1 ejhg2009239a.pdf: 524288 bytes, checksum: c7f749bf64ee8f577afa4b0ff0273840 (MD5) Previous issue date: 2010http://dx.doi.org/10.1038/ejhg.2009.239reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASialic acid-binding immunoglobulin-like lectin-8 (Siglec8)PolymorphismsAsthmaEosinophilic esophagitisPolymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthmaEuropean Journal of Human Geneticsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALejhg2009239a.pdfejhg2009239a.pdfapplication/pdf524288https://repositorio.ufba.br/bitstream/ri/12772/1/ejhg2009239a.pdfc7f749bf64ee8f577afa4b0ff0273840MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12772/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTejhg2009239a.pdf.txtejhg2009239a.pdf.txtExtracted texttext/plain44983https://repositorio.ufba.br/bitstream/ri/12772/3/ejhg2009239a.pdf.txtc58d0c01e9fc2f8a3b71dcba86a398e0MD53ri/127722022-07-05 14:02:49.109oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:49Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma
dc.title.alternative.pt_BR.fl_str_mv European Journal of Human Genetics
title Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma
spellingShingle Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma
Gao, Peisong
Sialic acid-binding immunoglobulin-like lectin-8 (Siglec8)
Polymorphisms
Asthma
Eosinophilic esophagitis
title_short Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma
title_full Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma
title_fullStr Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma
title_full_unstemmed Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma
title_sort Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma
author Gao, Peisong
author_facet Gao, Peisong
Shimizu, Kenichi
Grant, Audrey V.
Rafaels, Nicholas M.
Zhou, Lin-Fu
Hudson, Sherry A.
Konno, Satoshi
Zimmermann, Nives
Araujo, Maria
Ponte, Eduardo Vieira
Cruz Filho, Álvaro Augusto Souza da
author_role author
author2 Shimizu, Kenichi
Grant, Audrey V.
Rafaels, Nicholas M.
Zhou, Lin-Fu
Hudson, Sherry A.
Konno, Satoshi
Zimmermann, Nives
Araujo, Maria
Ponte, Eduardo Vieira
Cruz Filho, Álvaro Augusto Souza da
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gao, Peisong
Shimizu, Kenichi
Grant, Audrey V.
Rafaels, Nicholas M.
Zhou, Lin-Fu
Hudson, Sherry A.
Konno, Satoshi
Zimmermann, Nives
Araujo, Maria
Ponte, Eduardo Vieira
Cruz Filho, Álvaro Augusto Souza da
Gao, Peisong
Shimizu, Kenichi
Grant, Audrey V.
Rafaels, Nicholas M.
Zhou, Lin-Fu
Hudson, Sherry A.
Konno, Satoshi
Zimmermann, Nives
Araujo, Maria
Ponte, Eduardo Vieira
Cruz Filho, Álvaro Augusto Souza da
dc.subject.por.fl_str_mv Sialic acid-binding immunoglobulin-like lectin-8 (Siglec8)
Polymorphisms
Asthma
Eosinophilic esophagitis
topic Sialic acid-binding immunoglobulin-like lectin-8 (Siglec8)
Polymorphisms
Asthma
Eosinophilic esophagitis
description Texto completo: acesso restrito.p. 713-719
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2013-08-28T17:04:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12772
dc.identifier.issn.none.fl_str_mv 1018-4813
dc.identifier.number.pt_BR.fl_str_mv European Journal of Human Genetics
identifier_str_mv 1018-4813
European Journal of Human Genetics
url http://www.repositorio.ufba.br/ri/handle/ri/12772
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1038/ejhg.2009.239
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