The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes

Detalhes bibliográficos
Autor(a) principal: Lima, Maria de Lourdes
Data de Publicação: 1998
Outros Autores: Cruz, Thomaz Rodrigues Porto da, Pousada, Judith Maria Dias Carreiro, Rodrigues, Luiz Erlon, Barbosa, Karyne, Cangucu, Valquiria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12811
Resumo: p. 682-686
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spelling Lima, Maria de LourdesCruz, Thomaz Rodrigues Porto daPousada, Judith Maria Dias CarreiroRodrigues, Luiz ErlonBarbosa, KaryneCangucu, ValquiriaLima, Maria de LourdesCruz, Thomaz Rodrigues Porto daPousada, Judith Maria Dias CarreiroRodrigues, Luiz ErlonBarbosa, KaryneCangucu, Valquiria2013-09-03T12:55:44Z1998http://www.repositorio.ufba.br/ri/handle/ri/12811v. 21, n. 5p. 682-686OBJECTIVE — Hypomagnesemia occurs in 25-38% of patients with type 2 diabetes. Several studies have suggested an association between magnesium (Mg) depletion and insulin resistance and/or reduction of insulin secretion in these cases. Our purpose was to evaluate if Mg supplementation (as magnesium oxide [MgO]) would improve metabolic control in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS— We studied 128 patients with type 2 diabetes (32 men, 96 women, aged 30-69 years), treated by diet or diet plus oral antidiabetic drugs, in the Bahia Federal University Hospital, Brazil. Patients at risk for hypomagnesemia or with reduced renal function were excluded. This study was a clinical randomized double-blind placebo-controlled trial. Patients received either placebo, 20.7 mmol MgO, or 41.4 mmol MgO daily (elementary Mg) for 30 days. Mg concentrations were measured in plasma, in mononuclear cells, and in 24-h urine samples. Fasting blood glucose, HbAi, and fructosamine were used as parameters of metabolic control. RESULTS — Of the patients, 47.7% had low plasma Mg, and 31.1% had low intramononuclear Mg levels. Intracellular Mg in patients with diabetes was significantly lower than in the normal population (62 blood donors; 1.4 ± 0.6 vs. 1.7 ± 0.6 ug/mg of total proteins). No correlation was found between plasma and intracellular Mg concentrations (r = —0.179; P = 0.15) or between Mg concentrations and glycemic control (r = —0.165; P = 0.12). Intracellular Mg levels were lower in patients with peripheral neuropathy than in those without (1.2 ± 0.5 vs. 1.5 ± 0.6 ug/mg). Similar findings were observed in patients with coronary disease (1.0 ± 0.5 vs. 1.5 ± 0.6 ug/mg). In the placebo and in the 20.7 mmol Mg groups, neither a change in plasma and intracellular levels nor an improvement in glycemic control were observed. Replacement with 41.4 mmol Mg tended to increase plasma, cellular, and urine Mg and caused a significant fall (4.1 ± 0.8 to 3.8 ± 0.7 mmol/1) in fructosamine (normal, 1.87-2.87 mmol/1). CONCLUSIONS — Mg depletion is common in poorly controlled patients with type 2 diabetes, especially in those with neuropathy or coronary disease. More prolonged use of Mg in doses that are higher than usual is needed to establish its routine or selective administration in patients with type 2 diabetes to improve control or prevent chronic complications.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-08-20T17:59:42Z No. of bitstreams: 1 111111111.pdf: 945615 bytes, checksum: 44e1475dd5570d8d327c7092051f77ee (MD5)Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-09-03T12:55:44Z (GMT) No. of bitstreams: 1 111111111.pdf: 945615 bytes, checksum: 44e1475dd5570d8d327c7092051f77ee (MD5)Made available in DSpace on 2013-09-03T12:55:44Z (GMT). No. of bitstreams: 1 111111111.pdf: 945615 bytes, checksum: 44e1475dd5570d8d327c7092051f77ee (MD5) Previous issue date: 1998Salvadorthe American Diabetes Association10.2337/diacare.21.5.682reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAMagnesiumMagnesium - Administration e dosageDiabetes Mellitus Type 2The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 DiabetesDiabetes careinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12811/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINAL111111111.pdf111111111.pdfapplication/pdf945615https://repositorio.ufba.br/bitstream/ri/12811/1/111111111.pdf44e1475dd5570d8d327c7092051f77eeMD51TEXT111111111.pdf.txt111111111.pdf.txtExtracted texttext/plain23516https://repositorio.ufba.br/bitstream/ri/12811/3/111111111.pdf.txteb2eb5cfef0130030068bedc0585d7f1MD53ri/128112022-07-05 14:02:50.294oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:50Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes
dc.title.alternative.pt_BR.fl_str_mv Diabetes care
title The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes
spellingShingle The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes
Lima, Maria de Lourdes
Magnesium
Magnesium - Administration e dosage
Diabetes Mellitus Type 2
title_short The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes
title_full The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes
title_fullStr The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes
title_full_unstemmed The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes
title_sort The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes
author Lima, Maria de Lourdes
author_facet Lima, Maria de Lourdes
Cruz, Thomaz Rodrigues Porto da
Pousada, Judith Maria Dias Carreiro
Rodrigues, Luiz Erlon
Barbosa, Karyne
Cangucu, Valquiria
author_role author
author2 Cruz, Thomaz Rodrigues Porto da
Pousada, Judith Maria Dias Carreiro
Rodrigues, Luiz Erlon
Barbosa, Karyne
Cangucu, Valquiria
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Maria de Lourdes
Cruz, Thomaz Rodrigues Porto da
Pousada, Judith Maria Dias Carreiro
Rodrigues, Luiz Erlon
Barbosa, Karyne
Cangucu, Valquiria
Lima, Maria de Lourdes
Cruz, Thomaz Rodrigues Porto da
Pousada, Judith Maria Dias Carreiro
Rodrigues, Luiz Erlon
Barbosa, Karyne
Cangucu, Valquiria
dc.subject.por.fl_str_mv Magnesium
Magnesium - Administration e dosage
Diabetes Mellitus Type 2
topic Magnesium
Magnesium - Administration e dosage
Diabetes Mellitus Type 2
description p. 682-686
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2013-09-03T12:55:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12811
dc.identifier.number.pt_BR.fl_str_mv v. 21, n. 5
url http://www.repositorio.ufba.br/ri/handle/ri/12811
identifier_str_mv v. 21, n. 5
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv the American Diabetes Association
publisher.none.fl_str_mv the American Diabetes Association
dc.source.pt_BR.fl_str_mv 10.2337/diacare.21.5.682
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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