The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/12811 |
Resumo: | p. 682-686 |
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1932 |
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Lima, Maria de LourdesCruz, Thomaz Rodrigues Porto daPousada, Judith Maria Dias CarreiroRodrigues, Luiz ErlonBarbosa, KaryneCangucu, ValquiriaLima, Maria de LourdesCruz, Thomaz Rodrigues Porto daPousada, Judith Maria Dias CarreiroRodrigues, Luiz ErlonBarbosa, KaryneCangucu, Valquiria2013-09-03T12:55:44Z1998http://www.repositorio.ufba.br/ri/handle/ri/12811v. 21, n. 5p. 682-686OBJECTIVE — Hypomagnesemia occurs in 25-38% of patients with type 2 diabetes. Several studies have suggested an association between magnesium (Mg) depletion and insulin resistance and/or reduction of insulin secretion in these cases. Our purpose was to evaluate if Mg supplementation (as magnesium oxide [MgO]) would improve metabolic control in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS— We studied 128 patients with type 2 diabetes (32 men, 96 women, aged 30-69 years), treated by diet or diet plus oral antidiabetic drugs, in the Bahia Federal University Hospital, Brazil. Patients at risk for hypomagnesemia or with reduced renal function were excluded. This study was a clinical randomized double-blind placebo-controlled trial. Patients received either placebo, 20.7 mmol MgO, or 41.4 mmol MgO daily (elementary Mg) for 30 days. Mg concentrations were measured in plasma, in mononuclear cells, and in 24-h urine samples. Fasting blood glucose, HbAi, and fructosamine were used as parameters of metabolic control. RESULTS — Of the patients, 47.7% had low plasma Mg, and 31.1% had low intramononuclear Mg levels. Intracellular Mg in patients with diabetes was significantly lower than in the normal population (62 blood donors; 1.4 ± 0.6 vs. 1.7 ± 0.6 ug/mg of total proteins). No correlation was found between plasma and intracellular Mg concentrations (r = —0.179; P = 0.15) or between Mg concentrations and glycemic control (r = —0.165; P = 0.12). Intracellular Mg levels were lower in patients with peripheral neuropathy than in those without (1.2 ± 0.5 vs. 1.5 ± 0.6 ug/mg). Similar findings were observed in patients with coronary disease (1.0 ± 0.5 vs. 1.5 ± 0.6 ug/mg). In the placebo and in the 20.7 mmol Mg groups, neither a change in plasma and intracellular levels nor an improvement in glycemic control were observed. Replacement with 41.4 mmol Mg tended to increase plasma, cellular, and urine Mg and caused a significant fall (4.1 ± 0.8 to 3.8 ± 0.7 mmol/1) in fructosamine (normal, 1.87-2.87 mmol/1). CONCLUSIONS — Mg depletion is common in poorly controlled patients with type 2 diabetes, especially in those with neuropathy or coronary disease. More prolonged use of Mg in doses that are higher than usual is needed to establish its routine or selective administration in patients with type 2 diabetes to improve control or prevent chronic complications.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-08-20T17:59:42Z No. of bitstreams: 1 111111111.pdf: 945615 bytes, checksum: 44e1475dd5570d8d327c7092051f77ee (MD5)Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-09-03T12:55:44Z (GMT) No. of bitstreams: 1 111111111.pdf: 945615 bytes, checksum: 44e1475dd5570d8d327c7092051f77ee (MD5)Made available in DSpace on 2013-09-03T12:55:44Z (GMT). No. of bitstreams: 1 111111111.pdf: 945615 bytes, checksum: 44e1475dd5570d8d327c7092051f77ee (MD5) Previous issue date: 1998Salvadorthe American Diabetes Association10.2337/diacare.21.5.682reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAMagnesiumMagnesium - Administration e dosageDiabetes Mellitus Type 2The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 DiabetesDiabetes careinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12811/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINAL111111111.pdf111111111.pdfapplication/pdf945615https://repositorio.ufba.br/bitstream/ri/12811/1/111111111.pdf44e1475dd5570d8d327c7092051f77eeMD51TEXT111111111.pdf.txt111111111.pdf.txtExtracted texttext/plain23516https://repositorio.ufba.br/bitstream/ri/12811/3/111111111.pdf.txteb2eb5cfef0130030068bedc0585d7f1MD53ri/128112022-07-05 14:02:50.294oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:50Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes |
dc.title.alternative.pt_BR.fl_str_mv |
Diabetes care |
title |
The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes |
spellingShingle |
The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes Lima, Maria de Lourdes Magnesium Magnesium - Administration e dosage Diabetes Mellitus Type 2 |
title_short |
The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes |
title_full |
The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes |
title_fullStr |
The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes |
title_full_unstemmed |
The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes |
title_sort |
The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes |
author |
Lima, Maria de Lourdes |
author_facet |
Lima, Maria de Lourdes Cruz, Thomaz Rodrigues Porto da Pousada, Judith Maria Dias Carreiro Rodrigues, Luiz Erlon Barbosa, Karyne Cangucu, Valquiria |
author_role |
author |
author2 |
Cruz, Thomaz Rodrigues Porto da Pousada, Judith Maria Dias Carreiro Rodrigues, Luiz Erlon Barbosa, Karyne Cangucu, Valquiria |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Lima, Maria de Lourdes Cruz, Thomaz Rodrigues Porto da Pousada, Judith Maria Dias Carreiro Rodrigues, Luiz Erlon Barbosa, Karyne Cangucu, Valquiria Lima, Maria de Lourdes Cruz, Thomaz Rodrigues Porto da Pousada, Judith Maria Dias Carreiro Rodrigues, Luiz Erlon Barbosa, Karyne Cangucu, Valquiria |
dc.subject.por.fl_str_mv |
Magnesium Magnesium - Administration e dosage Diabetes Mellitus Type 2 |
topic |
Magnesium Magnesium - Administration e dosage Diabetes Mellitus Type 2 |
description |
p. 682-686 |
publishDate |
1998 |
dc.date.issued.fl_str_mv |
1998 |
dc.date.accessioned.fl_str_mv |
2013-09-03T12:55:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufba.br/ri/handle/ri/12811 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 21, n. 5 |
url |
http://www.repositorio.ufba.br/ri/handle/ri/12811 |
identifier_str_mv |
v. 21, n. 5 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
the American Diabetes Association |
publisher.none.fl_str_mv |
the American Diabetes Association |
dc.source.pt_BR.fl_str_mv |
10.2337/diacare.21.5.682 |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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Universidade Federal da Bahia (UFBA) |
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UFBA |
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UFBA |
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Repositório Institucional da UFBA |
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Repositório Institucional da UFBA |
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