Chronic virus infections supress atopy but not asthma in a set of children from a large Latin American city: a cross-section study
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/2838 |
Resumo: | Background: The prevalence of allergic diseases has increased over recent decades in affluent countries, but remains low in rural populations and some non-affluent countries. An explanation for these trends is that increased exposure to infections may provide protection against the development of allergy. In this work we investigated the association between exposure to viral infections in children living in urban Brazil and the prevalence of atopy and asthma. Methods: School age children living in poor neighborhoods in the city of Salvador were studied. Data on asthma symptoms and relevant risk factors were obtained by questionnaire. Skin prick tests (SPTs) were performed to seven aeroallergens, and specific IgE was measured to four of these. Viral infections were determined by the presence of specific IgG in serum to Herpes simplex (HSV), Herpes zoster (HZV), Epstein-Barr (EBV), and Hepatitis A (HAV) viruses. Results: A total of 644 (49.7%) children had at least one allergen-specific IgE> 0.35 kU/L and 489 (37.7%) had specific IgE> 0.70 kU/L. A total of 391 (30.2%) children were skin test positive (SPT+), and 295 (22.8%) children were asthmatic. The seroprevalence of viral infections was 88.9% for EBV, 55.4% for HSV, 45.5% for VZV and 17.5% for HAV. Negative associations were observed between SPT+ and HSV (OR = 0.64, CI = 0.51, 0.82) and EBV (OR = 0.63,CI = 0.44, 0.89) infections, but no associations were seen between viral infections and the presence of allergenspecific IgE or asthma. Conclusion: These data do not support previous data showing a protective effect of HAV against atopy, but did show inverse associations between SPT+ (but not specific IgE+) and infections with HSV and EBV. These findings suggest that different viral infections may protect against SPT+ in different settings and may indicate an immunoregulatory role of such infections on immediate ypersensitivity responses. The data provide no support for a protective effect of viral infections against asthma in this population. |
id |
UFBA-2_5de7a921ff5f3c76f5afa8a1bce4eeb5 |
---|---|
oai_identifier_str |
oai:repositorio.ufba.br:ri/2838 |
network_acronym_str |
UFBA-2 |
network_name_str |
Repositório Institucional da UFBA |
repository_id_str |
1932 |
spelling |
Veiga, Rafael ValenteCunha, Sergio Souza daDattoli, Vitor Camilo CavalcanteCruz Filho, Álvaro Augusto Souza daCooper, Phillip J.Rodrigues, Laura CunhaBarreto, Mauricio LimaNeves, Neuza Maria AlcântaraVeiga, Rafael ValenteCunha, Sergio Souza daDattoli, Vitor Camilo CavalcanteCruz Filho, Álvaro Augusto Souza daCooper, Phillip J.Rodrigues, Laura CunhaBarreto, Mauricio LimaNeves, Neuza Maria Alcântara2011-09-23T13:56:14Z2011-09-23T13:56:14Z20111471-2466http://www.repositorio.ufba.br/ri/handle/ri/2838v.11, p.3-8, 2011.Background: The prevalence of allergic diseases has increased over recent decades in affluent countries, but remains low in rural populations and some non-affluent countries. An explanation for these trends is that increased exposure to infections may provide protection against the development of allergy. In this work we investigated the association between exposure to viral infections in children living in urban Brazil and the prevalence of atopy and asthma. Methods: School age children living in poor neighborhoods in the city of Salvador were studied. Data on asthma symptoms and relevant risk factors were obtained by questionnaire. Skin prick tests (SPTs) were performed to seven aeroallergens, and specific IgE was measured to four of these. Viral infections were determined by the presence of specific IgG in serum to Herpes simplex (HSV), Herpes zoster (HZV), Epstein-Barr (EBV), and Hepatitis A (HAV) viruses. Results: A total of 644 (49.7%) children had at least one allergen-specific IgE> 0.35 kU/L and 489 (37.7%) had specific IgE> 0.70 kU/L. A total of 391 (30.2%) children were skin test positive (SPT+), and 295 (22.8%) children were asthmatic. The seroprevalence of viral infections was 88.9% for EBV, 55.4% for HSV, 45.5% for VZV and 17.5% for HAV. Negative associations were observed between SPT+ and HSV (OR = 0.64, CI = 0.51, 0.82) and EBV (OR = 0.63,CI = 0.44, 0.89) infections, but no associations were seen between viral infections and the presence of allergenspecific IgE or asthma. Conclusion: These data do not support previous data showing a protective effect of HAV against atopy, but did show inverse associations between SPT+ (but not specific IgE+) and infections with HSV and EBV. These findings suggest that different viral infections may protect against SPT+ in different settings and may indicate an immunoregulatory role of such infections on immediate ypersensitivity responses. The data provide no support for a protective effect of viral infections against asthma in this population.Submitted by Maria Creuza Silva (mariakreuza@yahoo.com.br) on 2011-09-23T13:56:13Z No. of bitstreams: 1 Per Inter 2011.3.pdf: 243579 bytes, checksum: 1e5185352bc37ab02fb14ad72fec5441 (MD5)Made available in DSpace on 2011-09-23T13:56:14Z (GMT). No. of bitstreams: 1 Per Inter 2011.3.pdf: 243579 bytes, checksum: 1e5185352bc37ab02fb14ad72fec5441 (MD5) Previous issue date: 2011LondresAsthmaVirus DiseasesChildrenChronic virus infections supress atopy but not asthma in a set of children from a large Latin American city: a cross-section studyBMC Pulm Medinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALPer Inter 2011.3.pdfPer Inter 2011.3.pdfapplication/pdf243579https://repositorio.ufba.br/bitstream/ri/2838/1/Per%20Inter%202011.3.pdf1e5185352bc37ab02fb14ad72fec5441MD51LICENSElicense.txtlicense.txttext/plain1907https://repositorio.ufba.br/bitstream/ri/2838/2/license.txt20d9827255c17c22cbb8f8ce0265575eMD52TEXTPer Inter 2011.3.pdf.txtPer Inter 2011.3.pdf.txtExtracted texttext/plain38224https://repositorio.ufba.br/bitstream/ri/2838/3/Per%20Inter%202011.3.pdf.txt3a8b844c509001389a1189ef75a6920cMD53ri/28382022-07-05 14:03:38.131oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:38Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Chronic virus infections supress atopy but not asthma in a set of children from a large Latin American city: a cross-section study |
dc.title.alternative.pt_BR.fl_str_mv |
BMC Pulm Med |
title |
Chronic virus infections supress atopy but not asthma in a set of children from a large Latin American city: a cross-section study |
spellingShingle |
Chronic virus infections supress atopy but not asthma in a set of children from a large Latin American city: a cross-section study Veiga, Rafael Valente Asthma Virus Diseases Children |
title_short |
Chronic virus infections supress atopy but not asthma in a set of children from a large Latin American city: a cross-section study |
title_full |
Chronic virus infections supress atopy but not asthma in a set of children from a large Latin American city: a cross-section study |
title_fullStr |
Chronic virus infections supress atopy but not asthma in a set of children from a large Latin American city: a cross-section study |
title_full_unstemmed |
Chronic virus infections supress atopy but not asthma in a set of children from a large Latin American city: a cross-section study |
title_sort |
Chronic virus infections supress atopy but not asthma in a set of children from a large Latin American city: a cross-section study |
author |
Veiga, Rafael Valente |
author_facet |
Veiga, Rafael Valente Cunha, Sergio Souza da Dattoli, Vitor Camilo Cavalcante Cruz Filho, Álvaro Augusto Souza da Cooper, Phillip J. Rodrigues, Laura Cunha Barreto, Mauricio Lima Neves, Neuza Maria Alcântara |
author_role |
author |
author2 |
Cunha, Sergio Souza da Dattoli, Vitor Camilo Cavalcante Cruz Filho, Álvaro Augusto Souza da Cooper, Phillip J. Rodrigues, Laura Cunha Barreto, Mauricio Lima Neves, Neuza Maria Alcântara |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Veiga, Rafael Valente Cunha, Sergio Souza da Dattoli, Vitor Camilo Cavalcante Cruz Filho, Álvaro Augusto Souza da Cooper, Phillip J. Rodrigues, Laura Cunha Barreto, Mauricio Lima Neves, Neuza Maria Alcântara Veiga, Rafael Valente Cunha, Sergio Souza da Dattoli, Vitor Camilo Cavalcante Cruz Filho, Álvaro Augusto Souza da Cooper, Phillip J. Rodrigues, Laura Cunha Barreto, Mauricio Lima Neves, Neuza Maria Alcântara |
dc.subject.por.fl_str_mv |
Asthma Virus Diseases Children |
topic |
Asthma Virus Diseases Children |
description |
Background: The prevalence of allergic diseases has increased over recent decades in affluent countries, but remains low in rural populations and some non-affluent countries. An explanation for these trends is that increased exposure to infections may provide protection against the development of allergy. In this work we investigated the association between exposure to viral infections in children living in urban Brazil and the prevalence of atopy and asthma. Methods: School age children living in poor neighborhoods in the city of Salvador were studied. Data on asthma symptoms and relevant risk factors were obtained by questionnaire. Skin prick tests (SPTs) were performed to seven aeroallergens, and specific IgE was measured to four of these. Viral infections were determined by the presence of specific IgG in serum to Herpes simplex (HSV), Herpes zoster (HZV), Epstein-Barr (EBV), and Hepatitis A (HAV) viruses. Results: A total of 644 (49.7%) children had at least one allergen-specific IgE> 0.35 kU/L and 489 (37.7%) had specific IgE> 0.70 kU/L. A total of 391 (30.2%) children were skin test positive (SPT+), and 295 (22.8%) children were asthmatic. The seroprevalence of viral infections was 88.9% for EBV, 55.4% for HSV, 45.5% for VZV and 17.5% for HAV. Negative associations were observed between SPT+ and HSV (OR = 0.64, CI = 0.51, 0.82) and EBV (OR = 0.63,CI = 0.44, 0.89) infections, but no associations were seen between viral infections and the presence of allergenspecific IgE or asthma. Conclusion: These data do not support previous data showing a protective effect of HAV against atopy, but did show inverse associations between SPT+ (but not specific IgE+) and infections with HSV and EBV. These findings suggest that different viral infections may protect against SPT+ in different settings and may indicate an immunoregulatory role of such infections on immediate ypersensitivity responses. The data provide no support for a protective effect of viral infections against asthma in this population. |
publishDate |
2011 |
dc.date.accessioned.fl_str_mv |
2011-09-23T13:56:14Z |
dc.date.available.fl_str_mv |
2011-09-23T13:56:14Z |
dc.date.issued.fl_str_mv |
2011 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufba.br/ri/handle/ri/2838 |
dc.identifier.issn.none.fl_str_mv |
1471-2466 |
dc.identifier.number.pt_BR.fl_str_mv |
v.11, p.3-8, 2011. |
identifier_str_mv |
1471-2466 v.11, p.3-8, 2011. |
url |
http://www.repositorio.ufba.br/ri/handle/ri/2838 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
instname_str |
Universidade Federal da Bahia (UFBA) |
instacron_str |
UFBA |
institution |
UFBA |
reponame_str |
Repositório Institucional da UFBA |
collection |
Repositório Institucional da UFBA |
bitstream.url.fl_str_mv |
https://repositorio.ufba.br/bitstream/ri/2838/1/Per%20Inter%202011.3.pdf https://repositorio.ufba.br/bitstream/ri/2838/2/license.txt https://repositorio.ufba.br/bitstream/ri/2838/3/Per%20Inter%202011.3.pdf.txt |
bitstream.checksum.fl_str_mv |
1e5185352bc37ab02fb14ad72fec5441 20d9827255c17c22cbb8f8ce0265575e 3a8b844c509001389a1189ef75a6920c |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA) |
repository.mail.fl_str_mv |
|
_version_ |
1801502413004210176 |