Prescription of antihypertensive agents to haemodialysis patients: time trends and associations with patient characteristics, country and survival in the DOPPS

Detalhes bibliográficos
Autor(a) principal: Lopes, Antonio Alberto da Silva
Data de Publicação: 2009
Outros Autores: Bragg Gresham, Jennifer L., Ramirez, Sylvia P. B., Andreucci, Vittorio E., Akiba, Takashi, Saito, Akira, Jacobson, Stefan H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13399
Resumo: Texto completo: acesso restrito. p. 2809-2816
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spelling Lopes, Antonio Alberto da SilvaBragg Gresham, Jennifer L.Ramirez, Sylvia P. B.Andreucci, Vittorio E.Akiba, TakashiSaito, AkiraJacobson, Stefan H.Lopes, Antonio Alberto da SilvaBragg Gresham, Jennifer L.Ramirez, Sylvia P. B.Andreucci, Vittorio E.Akiba, TakashiSaito, AkiraJacobson, Stefan H.2013-10-31T17:39:51Z20090931-0509http://repositorio.ufba.br/ri/handle/ri/13399v. 24, n. 9Texto completo: acesso restrito. p. 2809-2816Background. Haemodialysis patients were studied in 12 countries to identify practice patterns of prescription of antihypertensive agents (AHA) associated with survival. Methods. The sample included 28 513 patients enrolled in DOPPS I and II. The classes of AHA studied were beta blocker (BB), angiotensin-converting enzyme inhibitor (ACEI), angiotensin receptor blocker (ARB), peripheral blocker, central antagonist, vasodilator, long-acting dihydropyridine calcium channel blocker (CCB), short-acting dihydropyridine CCB and non-dihydropyridine CCB. To reduce bias due to unmeasured confounders, the associations with mortality were assessed by separate Cox models based on patient-level prescription and facility prescription practice. Results. An increase in prescription of ARBs (9.5%) and BBs (9.1%) was observed from DOPPS I to II. Prescription of AHA classes varied significantly by country, ranging for BBs from 9.7% in Japan to 52.7% in Sweden and for ARBs from 5.5% in Italy to 21.3% in Japan in DOPPS II. Facilities that treated 10% more patients with ARBs had, on average, 7% lower all-cause mortality, independent of patient characteristics and the prescription patterns of other antihypertensive medications (P = 0.05). Significant and independent associations with reduction in cardiovascular mortality were observed for ARBs (RR = 0.79; P = 0.005) and BBs (RR = 0.87, P = 0.004) in analyses of patient-level prescriptions. These associations in the facility-level model followed the same direction. Conclusions. DOPPS data show large variations across countries in AHA prescription for haemodialysis patients. The data suggest an association between ARB use and reduction in all-cause mortality, as well as with the use of BBs and reduction in cardiovascular mortality among haemodialysis patients.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-10-01T12:48:05Z No. of bitstreams: 1 Nephrol. Dial. Transplant.-2009-Lopes-2809-16.pdf: 378141 bytes, checksum: 0a0dc8c7698f82e17698345048565897 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-10-31T17:39:51Z (GMT) No. of bitstreams: 1 Nephrol. Dial. Transplant.-2009-Lopes-2809-16.pdf: 378141 bytes, checksum: 0a0dc8c7698f82e17698345048565897 (MD5)Made available in DSpace on 2013-10-31T17:39:51Z (GMT). No. of bitstreams: 1 Nephrol. Dial. Transplant.-2009-Lopes-2809-16.pdf: 378141 bytes, checksum: 0a0dc8c7698f82e17698345048565897 (MD5) Previous issue date: 2009http://dx.doi.org/10.1093/ndt/gfp212reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAntihypertensive agentsCardiovascularHaemodialysisMortalityPrescription of antihypertensive agents to haemodialysis patients: time trends and associations with patient characteristics, country and survival in the DOPPSNephrology Dialysis Transplantationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1365https://repositorio.ufba.br/bitstream/ri/13399/2/license.txt5371a150bdc863f78dcf39281543bd86MD52ORIGINALNephrol. Dial. Transplant.-2009-Lopes-2809-16.pdfNephrol. Dial. 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dc.title.pt_BR.fl_str_mv Prescription of antihypertensive agents to haemodialysis patients: time trends and associations with patient characteristics, country and survival in the DOPPS
dc.title.alternative.pt_BR.fl_str_mv Nephrology Dialysis Transplantation
title Prescription of antihypertensive agents to haemodialysis patients: time trends and associations with patient characteristics, country and survival in the DOPPS
spellingShingle Prescription of antihypertensive agents to haemodialysis patients: time trends and associations with patient characteristics, country and survival in the DOPPS
Lopes, Antonio Alberto da Silva
Antihypertensive agents
Cardiovascular
Haemodialysis
Mortality
title_short Prescription of antihypertensive agents to haemodialysis patients: time trends and associations with patient characteristics, country and survival in the DOPPS
title_full Prescription of antihypertensive agents to haemodialysis patients: time trends and associations with patient characteristics, country and survival in the DOPPS
title_fullStr Prescription of antihypertensive agents to haemodialysis patients: time trends and associations with patient characteristics, country and survival in the DOPPS
title_full_unstemmed Prescription of antihypertensive agents to haemodialysis patients: time trends and associations with patient characteristics, country and survival in the DOPPS
title_sort Prescription of antihypertensive agents to haemodialysis patients: time trends and associations with patient characteristics, country and survival in the DOPPS
author Lopes, Antonio Alberto da Silva
author_facet Lopes, Antonio Alberto da Silva
Bragg Gresham, Jennifer L.
Ramirez, Sylvia P. B.
Andreucci, Vittorio E.
Akiba, Takashi
Saito, Akira
Jacobson, Stefan H.
author_role author
author2 Bragg Gresham, Jennifer L.
Ramirez, Sylvia P. B.
Andreucci, Vittorio E.
Akiba, Takashi
Saito, Akira
Jacobson, Stefan H.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lopes, Antonio Alberto da Silva
Bragg Gresham, Jennifer L.
Ramirez, Sylvia P. B.
Andreucci, Vittorio E.
Akiba, Takashi
Saito, Akira
Jacobson, Stefan H.
Lopes, Antonio Alberto da Silva
Bragg Gresham, Jennifer L.
Ramirez, Sylvia P. B.
Andreucci, Vittorio E.
Akiba, Takashi
Saito, Akira
Jacobson, Stefan H.
dc.subject.por.fl_str_mv Antihypertensive agents
Cardiovascular
Haemodialysis
Mortality
topic Antihypertensive agents
Cardiovascular
Haemodialysis
Mortality
description Texto completo: acesso restrito. p. 2809-2816
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2013-10-31T17:39:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13399
dc.identifier.issn.none.fl_str_mv 0931-0509
dc.identifier.number.pt_BR.fl_str_mv v. 24, n. 9
identifier_str_mv 0931-0509
v. 24, n. 9
url http://repositorio.ufba.br/ri/handle/ri/13399
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1093/ndt/gfp212
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