Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding study

Detalhes bibliográficos
Autor(a) principal: Coutinho, Elsimar Metzker
Data de Publicação: 2000
Outros Autores: Athayde, Célia Maria Soares, Atta, Gabriel, Emuveyan, Edward E., Adekunle, Adeyemi O., Mati, Japheth, Otubu, Joseph
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7963
Resumo: Texto completo: acesso restrito. p.61–67
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spelling Coutinho, Elsimar MetzkerAthayde, Célia Maria SoaresAtta, GabrielEmuveyan, Edward E.Adekunle, Adeyemi O.Mati, JaphethOtubu, JosephCoutinho, Elsimar MetzkerAthayde, Célia Maria SoaresAtta, GabrielEmuveyan, Edward E.Adekunle, Adeyemi O.Mati, JaphethOtubu, Joseph2013-01-17T10:32:43Z20000010-7824http://www.repositorio.ufba.br/ri/handle/ri/7963v. 61, n. 1Texto completo: acesso restrito. p.61–67The safety and efficacy of gossypol continues to be controversial. The aim of this study was to evaluate gossypol as a contraceptive pill for men at doses lower than those previously prescribed and in men from various ethnic origin. A total of 151 men from Brazil, Nigeria, Kenya, and China were divided into two groups. Both groups received 15 mg gossypol/day for 12 or 16 weeks to reach spermatogenesis suppression. Subjects were then randomized to either 7.5 or 10 mg/day for 40 weeks. In addition, 51 men were enrolled as a control group. In all, 81 subjects attained spermatogenesis suppression. Only one man discontinued treatment because of tiredness. Potassium levels fluctuated within the normal range. FSH increased consistently. Testicular volume decreased, but after discontinuation, values returned to levels not statistically different from admission. Of 19 subjects on the 7.5 mg/day dose group, 12 recovered sperm counts >20 million/mL within 12 months of discontinuing gossypol. In the 10 mg/day group, sperm counts recovered in only 10 of 24 subjects. Eight of the 43 patients remained azoospermic 1 year after stopping gossypol. All men diagnosed with varicocele failed to reverse spermatogenesis suppression. Gossypol blood levels indicated that sperm suppression occurs independently of concentration, whereas spermatogenesis recovery appears to be concentration-dependent. Gossypol may become a medical alternative to surgical vasectomy when the delay in onset of infertility is acceptable. When taken for 1 year, gossypol causes no reduction in sexual desire or frequency of intercourse. The possibility of reversal, occurring in 51% of the men on this regimen within 1 year after stopping gossypol, is an advantage of this compound as compared with surgical sterilization in many parts of the world.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-01-17T10:32:43Z No. of bitstreams: 1 Coutinho.pdf: 219157 bytes, checksum: e708c6776a6441975fa360f67ee9316b (MD5)Made available in DSpace on 2013-01-17T10:32:43Z (GMT). No. of bitstreams: 1 Coutinho.pdf: 219157 bytes, checksum: e708c6776a6441975fa360f67ee9316b (MD5) Previous issue date: 2000http://dx.doi.org/10.1016/S0010-7824(99)00117-1reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAgossypolspermatogenesis suppressionreversibilityplasma gossypol levelspotassium levelsGossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding studyContraceptioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALCoutinho.pdfCoutinho.pdfapplication/pdf219157https://repositorio.ufba.br/bitstream/ri/7963/1/Coutinho.pdfe708c6776a6441975fa360f67ee9316bMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7963/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTCoutinho.pdf.txtCoutinho.pdf.txtExtracted texttext/plain29434https://repositorio.ufba.br/bitstream/ri/7963/3/Coutinho.pdf.txtf808101a48726d14c5fdb1d4925a690dMD53ri/79632022-07-05 14:03:20.495oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:20Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding study
dc.title.alternative.pt_BR.fl_str_mv Contraception
title Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding study
spellingShingle Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding study
Coutinho, Elsimar Metzker
gossypol
spermatogenesis suppression
reversibility
plasma gossypol levels
potassium levels
title_short Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding study
title_full Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding study
title_fullStr Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding study
title_full_unstemmed Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding study
title_sort Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding study
author Coutinho, Elsimar Metzker
author_facet Coutinho, Elsimar Metzker
Athayde, Célia Maria Soares
Atta, Gabriel
Emuveyan, Edward E.
Adekunle, Adeyemi O.
Mati, Japheth
Otubu, Joseph
author_role author
author2 Athayde, Célia Maria Soares
Atta, Gabriel
Emuveyan, Edward E.
Adekunle, Adeyemi O.
Mati, Japheth
Otubu, Joseph
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Coutinho, Elsimar Metzker
Athayde, Célia Maria Soares
Atta, Gabriel
Emuveyan, Edward E.
Adekunle, Adeyemi O.
Mati, Japheth
Otubu, Joseph
Coutinho, Elsimar Metzker
Athayde, Célia Maria Soares
Atta, Gabriel
Emuveyan, Edward E.
Adekunle, Adeyemi O.
Mati, Japheth
Otubu, Joseph
dc.subject.por.fl_str_mv gossypol
spermatogenesis suppression
reversibility
plasma gossypol levels
potassium levels
topic gossypol
spermatogenesis suppression
reversibility
plasma gossypol levels
potassium levels
description Texto completo: acesso restrito. p.61–67
publishDate 2000
dc.date.issued.fl_str_mv 2000
dc.date.accessioned.fl_str_mv 2013-01-17T10:32:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7963
dc.identifier.issn.none.fl_str_mv 0010-7824
dc.identifier.number.pt_BR.fl_str_mv v. 61, n. 1
identifier_str_mv 0010-7824
v. 61, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/7963
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/S0010-7824(99)00117-1
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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