Association of Type 2 Cytokines with Hepatic Fibrosis in Human Schistosoma mansoni Infection

Detalhes bibliográficos
Autor(a) principal: Jesus, Amélia Ribeiro de
Data de Publicação: 2004
Outros Autores: Magalhães, Andréa, Miranda, Delfin Gonzalez, Araujo, Maria Ilma Andrade Santos, Jesus, Adriana Almeida de, Silva, Angela, Santana, Luciana B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7318
Resumo: Texto completo : acesso restrito. p. 3391-3397
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spelling Jesus, Amélia Ribeiro deMagalhães, AndréaMiranda, Delfin GonzalezAraujo, Maria Ilma Andrade SantosJesus, Adriana Almeida deSilva, AngelaSantana, Luciana B.Jesus, Amélia Ribeiro deMagalhães, AndréaMiranda, Delfin GonzalezAraujo, Maria Ilma Andrade SantosJesus, Adriana Almeida deSilva, AngelaSantana, Luciana B.2012-12-07T14:02:48Z20040019-9567http://www.repositorio.ufba.br/ri/handle/ri/7318v. 72, n. 6Texto completo : acesso restrito. p. 3391-3397The objective of this study was to evaluate the role of cytokines in hepatic fibrosis in the prehepatosplenic and early hepatosplenic stages of schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography of 94 patients. Immunological evaluation was performed by the measurement of secreted cytokines (interleukin- 5 [IL-5], IL-10, IL-13, gamma interferon, tumor necrosis factor alpha, and transforming growth factor ) in peripheral blood mononuclear cells (PBMC) stimulated by Schistosoma mansoni antigens. Significantly,higher levels of IL-5, IL-10, and IL-13 were found in supernatants of soluble egg antigen-stimulated PBMC from subjects with degree III hepatic fibrosis compared to patients with degree I or II fibrosis. Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for 1 year following initial assessment and developed more serious fibrosis during this period. The data suggest a role for type 2 cytokines in hepatic fibrosis in human schistosomiasis mansoni.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-12-07T14:02:48Z No. of bitstreams: 1 3391.full.pdf: 205475 bytes, checksum: 8def4ef0fd1f75c2acc6c668ed79e222 (MD5)Made available in DSpace on 2012-12-07T14:02:48Z (GMT). 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dc.title.pt_BR.fl_str_mv Association of Type 2 Cytokines with Hepatic Fibrosis in Human Schistosoma mansoni Infection
dc.title.alternative.pt_BR.fl_str_mv Infection and Immunity
title Association of Type 2 Cytokines with Hepatic Fibrosis in Human Schistosoma mansoni Infection
spellingShingle Association of Type 2 Cytokines with Hepatic Fibrosis in Human Schistosoma mansoni Infection
Jesus, Amélia Ribeiro de
title_short Association of Type 2 Cytokines with Hepatic Fibrosis in Human Schistosoma mansoni Infection
title_full Association of Type 2 Cytokines with Hepatic Fibrosis in Human Schistosoma mansoni Infection
title_fullStr Association of Type 2 Cytokines with Hepatic Fibrosis in Human Schistosoma mansoni Infection
title_full_unstemmed Association of Type 2 Cytokines with Hepatic Fibrosis in Human Schistosoma mansoni Infection
title_sort Association of Type 2 Cytokines with Hepatic Fibrosis in Human Schistosoma mansoni Infection
author Jesus, Amélia Ribeiro de
author_facet Jesus, Amélia Ribeiro de
Magalhães, Andréa
Miranda, Delfin Gonzalez
Araujo, Maria Ilma Andrade Santos
Jesus, Adriana Almeida de
Silva, Angela
Santana, Luciana B.
author_role author
author2 Magalhães, Andréa
Miranda, Delfin Gonzalez
Araujo, Maria Ilma Andrade Santos
Jesus, Adriana Almeida de
Silva, Angela
Santana, Luciana B.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Jesus, Amélia Ribeiro de
Magalhães, Andréa
Miranda, Delfin Gonzalez
Araujo, Maria Ilma Andrade Santos
Jesus, Adriana Almeida de
Silva, Angela
Santana, Luciana B.
Jesus, Amélia Ribeiro de
Magalhães, Andréa
Miranda, Delfin Gonzalez
Araujo, Maria Ilma Andrade Santos
Jesus, Adriana Almeida de
Silva, Angela
Santana, Luciana B.
description Texto completo : acesso restrito. p. 3391-3397
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2012-12-07T14:02:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7318
dc.identifier.issn.none.fl_str_mv 0019-9567
dc.identifier.number.pt_BR.fl_str_mv v. 72, n. 6
identifier_str_mv 0019-9567
v. 72, n. 6
url http://www.repositorio.ufba.br/ri/handle/ri/7318
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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