Epithelial shedding is associated with nasal reactions to cold, dry air

Detalhes bibliográficos
Autor(a) principal: Cruz Filho, Álvaro Augusto Souza da
Data de Publicação: 2006
Outros Autores: Naclerio, Robert M., Proud, David, Togias, Alkis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6519
Resumo: RESTRITO
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spelling Cruz Filho, Álvaro Augusto Souza daNaclerio, Robert M.Proud, DavidTogias, AlkisCruz Filho, Álvaro Augusto Souza daNaclerio, Robert M.Proud, DavidTogias, Alkis2012-07-31T18:56:49Z2012-07-31T18:56:49Z20060091-6749http://www.repositorio.ufba.br/ri/handle/ri/6519v.117, n.6RESTRITOBackground Cold, dry air (CDA) can cause symptoms of rhinitis and obstructive airway responses. The pathophysiology of these reactions is not understood. One hypothesis is that the respiratory mucosa of individuals with CDA sensitivity cannot compensate for the loss of water that occurs on exposure to the stimulus, leading to epithelial damage. Objective To test for an association between nasal reactions to CDA and the number of epithelial cells recovered in nasal fluids. Methods Ten CDA-sensitive subjects received nasal provocations with CDA and warm, moist air; 10 CDA-insensitive subjects received CDA; and 10 subjects with allergic rhinitis received allergen and diluent challenges. Nasal lavage cytology was performed at baseline and after the challenge. Symptoms were recorded and histamine, [3H]-N-α-tosyl-L-arginine methyl ester-esterase activity, tryptase, and albumin were assayed in nasal lavages. Results A 6-fold increase in nasal lavage epithelial cells was found in the CDA-sensitive group after CDA (P < .01), but not after warm, moist air. No changes were observed in the CDA-insensitive group, or after allergen or diluent in allergic rhinitis. Conclusion Epithelial cell shedding accompanies clinical responses to CDA in the human nose. This supports the hypothesis that the airway mucosa of CDA-sensitive individuals cannot compensate for the water loss that occurs under extreme conditions leading to epithelial damage. Clinical implications A defect in mucosal water homeostasis may need to be considered in individuals who get excessive nasal symptoms when exposed to cold and dry, windy environment.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2012-07-31T18:56:49Z No. of bitstreams: 1 DD.pdf: 265590 bytes, checksum: 6e3d0b1a12f7db40dd1f418bd2029edb (MD5)Made available in DSpace on 2012-07-31T18:56:49Z (GMT). No. of bitstreams: 1 DD.pdf: 265590 bytes, checksum: 6e3d0b1a12f7db40dd1f418bd2029edb (MD5) Previous issue date: 2006Journal of Allergy and Clinical Immunologyhttp://dx.doi.org/10.1016/j.jaci.2006.01.054reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHyperosmolarityhypertonicitynasal allergen provocationnasal lavagenasal challengeEpithelial shedding is associated with nasal reactions to cold, dry airJournal of Allergy and Clinical Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALDD.pdfDD.pdfapplication/pdf265590https://repositorio.ufba.br/bitstream/ri/6519/1/DD.pdf6e3d0b1a12f7db40dd1f418bd2029edbMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6519/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTDD.pdf.txtDD.pdf.txtExtracted texttext/plain39945https://repositorio.ufba.br/bitstream/ri/6519/3/DD.pdf.txt7bceda5678bbd1c75a4e343f07c65b54MD53ri/65192022-07-05 14:03:22.34oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:22Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Epithelial shedding is associated with nasal reactions to cold, dry air
dc.title.alternative.pt_BR.fl_str_mv Journal of Allergy and Clinical Immunology
title Epithelial shedding is associated with nasal reactions to cold, dry air
spellingShingle Epithelial shedding is associated with nasal reactions to cold, dry air
Cruz Filho, Álvaro Augusto Souza da
Hyperosmolarity
hypertonicity
nasal allergen provocation
nasal lavage
nasal challenge
title_short Epithelial shedding is associated with nasal reactions to cold, dry air
title_full Epithelial shedding is associated with nasal reactions to cold, dry air
title_fullStr Epithelial shedding is associated with nasal reactions to cold, dry air
title_full_unstemmed Epithelial shedding is associated with nasal reactions to cold, dry air
title_sort Epithelial shedding is associated with nasal reactions to cold, dry air
author Cruz Filho, Álvaro Augusto Souza da
author_facet Cruz Filho, Álvaro Augusto Souza da
Naclerio, Robert M.
Proud, David
Togias, Alkis
author_role author
author2 Naclerio, Robert M.
Proud, David
Togias, Alkis
author2_role author
author
author
dc.contributor.author.fl_str_mv Cruz Filho, Álvaro Augusto Souza da
Naclerio, Robert M.
Proud, David
Togias, Alkis
Cruz Filho, Álvaro Augusto Souza da
Naclerio, Robert M.
Proud, David
Togias, Alkis
dc.subject.por.fl_str_mv Hyperosmolarity
hypertonicity
nasal allergen provocation
nasal lavage
nasal challenge
topic Hyperosmolarity
hypertonicity
nasal allergen provocation
nasal lavage
nasal challenge
description RESTRITO
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2012-07-31T18:56:49Z
dc.date.available.fl_str_mv 2012-07-31T18:56:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6519
dc.identifier.issn.none.fl_str_mv 0091-6749
dc.identifier.number.pt_BR.fl_str_mv v.117, n.6
identifier_str_mv 0091-6749
v.117, n.6
url http://www.repositorio.ufba.br/ri/handle/ri/6519
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Journal of Allergy and Clinical Immunology
publisher.none.fl_str_mv Journal of Allergy and Clinical Immunology
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.jaci.2006.01.054
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
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