Cardiovascular responses evoked by activation or blockade of GABAA receptors in the hypothalamic PVN are attenuated in transgenic rats with low brain angiotensinogen
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/15612 |
Resumo: | Texto completo: acesso restrito. p. 101–110 |
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Silva, Ana Quênia Gomes daXavier, Carlos HenriqueSantos, Maria Jose CampagnoleCaligiorne, Sordaini M.Baltatu, Ovidiu C.Bader, MichaelSantos, Robson Augusto S.Fontes, Marco Antônio P.Silva, Ana Quênia Gomes daXavier, Carlos HenriqueSantos, Maria Jose CampagnoleCaligiorne, Sordaini M.Baltatu, Ovidiu C.Bader, MichaelSantos, Robson Augusto S.Fontes, Marco Antônio P.2014-08-13T17:42:55Z20120006-8993http://repositorio.ufba.br/ri/handle/ri/15612v. 1448, n. 11Texto completo: acesso restrito. p. 101–110Previous evidence indicates that a balance between inhibitory gabaergic and excitatory angiotensinergic factors in the PVN is important for cardiovascular control. We investigated the cardiovascular response evoked from activation or blockade of GABAA receptors in the paraventricular nucleus (PVN), in transgenic rats with low brain angiotensinogen [TGR(ASrAOGEN)]. Brain Ang II and Ang-(1–7) levels were also determined. In functional experiments, TGR(ASrAOGEN) and Sprague–Dawley rats (SD, control) were anesthetized with urethane and blood pressure (BP), heart rate (HR) and renal sympathetic nerve activity (RSNA) were recorded. Brain Ang II and Ang-(1–7) levels were largely reduced in TGR(ASrAOGEN) compared with SD rats. Inhibition of PVN neurons with the GABAA agonist, muscimol (1 nmol/100 nL), resulted in an attenuated fall in all cardiovascular variables in TGR(ASrAOGEN) compared with SD rats. This difference was particularly pronounced in HR (TGR Mus − 23 ± 6 bpm vs. − 77 ± 9 bpm SD Mus; P < 0.05) and RSNA (TGR − 3 ± 10% vs.− 29 ± 8% SD; P < 0.05). Furthermore, the sympathetic response evoked by blockade of GABAA receptors in the PVN of TGR(ASrAOGEN) was also largely suppressed. The present data indicate that the sympathetic outflow mediated by PVN neurons under basal conditions is suppressed in TGR(ASrAOGEN) rats corroborating the functional significance of brain angiotensin production in the central regulation of sympathetic output to the cardiovascular system.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-13T12:32:57Z No. of bitstreams: 1 Ana Quênia Gomes da Silva.pdf: 1022444 bytes, checksum: c9a649d588aa92a5a0fa56af97acb968 (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-08-13T17:42:55Z (GMT) No. of bitstreams: 1 Ana Quênia Gomes da Silva.pdf: 1022444 bytes, checksum: c9a649d588aa92a5a0fa56af97acb968 (MD5)Made available in DSpace on 2014-08-13T17:42:55Z (GMT). No. of bitstreams: 1 Ana Quênia Gomes da Silva.pdf: 1022444 bytes, checksum: c9a649d588aa92a5a0fa56af97acb968 (MD5) Previous issue date: 2012http://dx.doi.org/ 10.1016/j.brainres.2012.02.021reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBABrain renin-angiotensin systemSympathetic toneParaventricular nucleusTransgenic ratCardiovascular responses evoked by activation or blockade of GABAA receptors in the hypothalamic PVN are attenuated in transgenic rats with low brain angiotensinogenBrain Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALAna Quênia Gomes da Silva.pdfAna Quênia Gomes da Silva.pdfapplication/pdf1022444https://repositorio.ufba.br/bitstream/ri/15612/1/Ana%20Qu%c3%aania%20Gomes%20da%20Silva.pdfc9a649d588aa92a5a0fa56af97acb968MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15612/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTAna Quênia Gomes da Silva.pdf.txtAna Quênia Gomes da Silva.pdf.txtExtracted texttext/plain38358https://repositorio.ufba.br/bitstream/ri/15612/3/Ana%20Qu%c3%aania%20Gomes%20da%20Silva.pdf.txt0e2498461583195280e91997ad60a858MD53ri/156122022-07-05 14:03:31.01oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:31Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Cardiovascular responses evoked by activation or blockade of GABAA receptors in the hypothalamic PVN are attenuated in transgenic rats with low brain angiotensinogen |
| dc.title.alternative.pt_BR.fl_str_mv |
Brain Research |
| title |
Cardiovascular responses evoked by activation or blockade of GABAA receptors in the hypothalamic PVN are attenuated in transgenic rats with low brain angiotensinogen |
| spellingShingle |
Cardiovascular responses evoked by activation or blockade of GABAA receptors in the hypothalamic PVN are attenuated in transgenic rats with low brain angiotensinogen Silva, Ana Quênia Gomes da Brain renin-angiotensin system Sympathetic tone Paraventricular nucleus Transgenic rat |
| title_short |
Cardiovascular responses evoked by activation or blockade of GABAA receptors in the hypothalamic PVN are attenuated in transgenic rats with low brain angiotensinogen |
| title_full |
Cardiovascular responses evoked by activation or blockade of GABAA receptors in the hypothalamic PVN are attenuated in transgenic rats with low brain angiotensinogen |
| title_fullStr |
Cardiovascular responses evoked by activation or blockade of GABAA receptors in the hypothalamic PVN are attenuated in transgenic rats with low brain angiotensinogen |
| title_full_unstemmed |
Cardiovascular responses evoked by activation or blockade of GABAA receptors in the hypothalamic PVN are attenuated in transgenic rats with low brain angiotensinogen |
| title_sort |
Cardiovascular responses evoked by activation or blockade of GABAA receptors in the hypothalamic PVN are attenuated in transgenic rats with low brain angiotensinogen |
| author |
Silva, Ana Quênia Gomes da |
| author_facet |
Silva, Ana Quênia Gomes da Xavier, Carlos Henrique Santos, Maria Jose Campagnole Caligiorne, Sordaini M. Baltatu, Ovidiu C. Bader, Michael Santos, Robson Augusto S. Fontes, Marco Antônio P. |
| author_role |
author |
| author2 |
Xavier, Carlos Henrique Santos, Maria Jose Campagnole Caligiorne, Sordaini M. Baltatu, Ovidiu C. Bader, Michael Santos, Robson Augusto S. Fontes, Marco Antônio P. |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Ana Quênia Gomes da Xavier, Carlos Henrique Santos, Maria Jose Campagnole Caligiorne, Sordaini M. Baltatu, Ovidiu C. Bader, Michael Santos, Robson Augusto S. Fontes, Marco Antônio P. Silva, Ana Quênia Gomes da Xavier, Carlos Henrique Santos, Maria Jose Campagnole Caligiorne, Sordaini M. Baltatu, Ovidiu C. Bader, Michael Santos, Robson Augusto S. Fontes, Marco Antônio P. |
| dc.subject.por.fl_str_mv |
Brain renin-angiotensin system Sympathetic tone Paraventricular nucleus Transgenic rat |
| topic |
Brain renin-angiotensin system Sympathetic tone Paraventricular nucleus Transgenic rat |
| description |
Texto completo: acesso restrito. p. 101–110 |
| publishDate |
2012 |
| dc.date.issued.fl_str_mv |
2012 |
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2014-08-13T17:42:55Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://repositorio.ufba.br/ri/handle/ri/15612 |
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0006-8993 |
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v. 1448, n. 11 |
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0006-8993 v. 1448, n. 11 |
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http://repositorio.ufba.br/ri/handle/ri/15612 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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http://dx.doi.org/ 10.1016/j.brainres.2012.02.021 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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