A cellular automata model for avascular solid tumor growth under the effect of therapy

Detalhes bibliográficos
Autor(a) principal: Reis, E. A.
Data de Publicação: 2009
Outros Autores: Santos, L. B. L., Pinho, Suani Tavares Rubim de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/13216
Resumo: Texto completo: acesso restrito. p. 1303-1314
id UFBA-2_6f790ce1af7bc34cbb2b3650455af7f0
oai_identifier_str oai:repositorio.ufba.br:ri/13216
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Reis, E. A.Santos, L. B. L.Pinho, Suani Tavares Rubim deReis, E. A.Santos, L. B. L.Pinho, Suani Tavares Rubim de2013-10-15T15:11:41Z20090378-4371http://www.repositorio.ufba.br/ri/handle/ri/13216v. 388, n. 7Texto completo: acesso restrito. p. 1303-1314Tumor growth has long been a target of investigation within the context of mathematical and computer modeling. The objective of this study is to propose and analyze a two-dimensional stochastic cellular automata model to describe avascular solid tumor growth, taking into account both the competition between cancer cells and normal cells for nutrients and/or space and a time-dependent proliferation of cancer cells. Gompertzian growth, characteristic of some tumors, is described and some of the features of the time-spatial pattern of solid tumors, such as compact morphology with irregular borders, are captured. The parameter space is studied in order to analyze the occurrence of necrosis and the response to therapy. Our findings suggest that transitions exist between necrotic and non-necrotic phases (no-therapy cases), and between the states of cure and non-cure (therapy cases). To analyze cure, the control and order parameters are, respectively, the highest probability of cancer cell proliferation and the probability of the therapeutic effect on cancer cells. With respect to patterns, it is possible to observe the inner necrotic core and the effect of the therapy destroying the tumor from its outer borders inwards.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-10-15T14:24:51Z No. of bitstreams: 1 1-s2.0-S0378437108009849-main.pdf: 2320182 bytes, checksum: 564ad13087eb10af07fe823f607ad2da (MD5)Approved for entry into archive by Rodrigo Meirelles(rodrigomei@ufba.br) on 2013-10-15T15:11:41Z (GMT) No. of bitstreams: 1 1-s2.0-S0378437108009849-main.pdf: 2320182 bytes, checksum: 564ad13087eb10af07fe823f607ad2da (MD5)Made available in DSpace on 2013-10-15T15:11:41Z (GMT). No. of bitstreams: 1 1-s2.0-S0378437108009849-main.pdf: 2320182 bytes, checksum: 564ad13087eb10af07fe823f607ad2da (MD5) Previous issue date: 2009http://dx.doi.org/10.1016/j.physa.2008.11.038reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBATumor growthCellular automataParameter spaceNecrosisTherapyA cellular automata model for avascular solid tumor growth under the effect of therapyPhysica A: Statistical Mechanics and its Applicationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL1-s2.0-S0378437108009849-main.pdf1-s2.0-S0378437108009849-main.pdfapplication/pdf2320182https://repositorio.ufba.br/bitstream/ri/13216/1/1-s2.0-S0378437108009849-main.pdf564ad13087eb10af07fe823f607ad2daMD51LICENSElicense.txtlicense.txttext/plain1365https://repositorio.ufba.br/bitstream/ri/13216/2/license.txt5371a150bdc863f78dcf39281543bd86MD52TEXT1-s2.0-S0378437108009849-main.pdf.txt1-s2.0-S0378437108009849-main.pdf.txtExtracted texttext/plain36930https://repositorio.ufba.br/bitstream/ri/13216/3/1-s2.0-S0378437108009849-main.pdf.txtcd1d5580f2b453b8e40fc193a062ac47MD53ri/132162022-07-05 14:03:48.203oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:48Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv A cellular automata model for avascular solid tumor growth under the effect of therapy
dc.title.alternative.pt_BR.fl_str_mv Physica A: Statistical Mechanics and its Applications
title A cellular automata model for avascular solid tumor growth under the effect of therapy
spellingShingle A cellular automata model for avascular solid tumor growth under the effect of therapy
Reis, E. A.
Tumor growth
Cellular automata
Parameter space
Necrosis
Therapy
title_short A cellular automata model for avascular solid tumor growth under the effect of therapy
title_full A cellular automata model for avascular solid tumor growth under the effect of therapy
title_fullStr A cellular automata model for avascular solid tumor growth under the effect of therapy
title_full_unstemmed A cellular automata model for avascular solid tumor growth under the effect of therapy
title_sort A cellular automata model for avascular solid tumor growth under the effect of therapy
author Reis, E. A.
author_facet Reis, E. A.
Santos, L. B. L.
Pinho, Suani Tavares Rubim de
author_role author
author2 Santos, L. B. L.
Pinho, Suani Tavares Rubim de
author2_role author
author
dc.contributor.author.fl_str_mv Reis, E. A.
Santos, L. B. L.
Pinho, Suani Tavares Rubim de
Reis, E. A.
Santos, L. B. L.
Pinho, Suani Tavares Rubim de
dc.subject.por.fl_str_mv Tumor growth
Cellular automata
Parameter space
Necrosis
Therapy
topic Tumor growth
Cellular automata
Parameter space
Necrosis
Therapy
description Texto completo: acesso restrito. p. 1303-1314
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2013-10-15T15:11:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/13216
dc.identifier.issn.none.fl_str_mv 0378-4371
dc.identifier.number.pt_BR.fl_str_mv v. 388, n. 7
identifier_str_mv 0378-4371
v. 388, n. 7
url http://www.repositorio.ufba.br/ri/handle/ri/13216
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.physa.2008.11.038
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/13216/1/1-s2.0-S0378437108009849-main.pdf
https://repositorio.ufba.br/bitstream/ri/13216/2/license.txt
https://repositorio.ufba.br/bitstream/ri/13216/3/1-s2.0-S0378437108009849-main.pdf.txt
bitstream.checksum.fl_str_mv 564ad13087eb10af07fe823f607ad2da
5371a150bdc863f78dcf39281543bd86
cd1d5580f2b453b8e40fc193a062ac47
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1801502521909313536

Registros relacionados