A cellular automata model for avascular solid tumor growth under the effect of therapy
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/13216 |
Resumo: | Texto completo: acesso restrito. p. 1303-1314 |
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Reis, E. A.Santos, L. B. L.Pinho, Suani Tavares Rubim deReis, E. A.Santos, L. B. L.Pinho, Suani Tavares Rubim de2013-10-15T15:11:41Z20090378-4371http://www.repositorio.ufba.br/ri/handle/ri/13216v. 388, n. 7Texto completo: acesso restrito. p. 1303-1314Tumor growth has long been a target of investigation within the context of mathematical and computer modeling. The objective of this study is to propose and analyze a two-dimensional stochastic cellular automata model to describe avascular solid tumor growth, taking into account both the competition between cancer cells and normal cells for nutrients and/or space and a time-dependent proliferation of cancer cells. Gompertzian growth, characteristic of some tumors, is described and some of the features of the time-spatial pattern of solid tumors, such as compact morphology with irregular borders, are captured. The parameter space is studied in order to analyze the occurrence of necrosis and the response to therapy. Our findings suggest that transitions exist between necrotic and non-necrotic phases (no-therapy cases), and between the states of cure and non-cure (therapy cases). To analyze cure, the control and order parameters are, respectively, the highest probability of cancer cell proliferation and the probability of the therapeutic effect on cancer cells. With respect to patterns, it is possible to observe the inner necrotic core and the effect of the therapy destroying the tumor from its outer borders inwards.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-10-15T14:24:51Z No. of bitstreams: 1 1-s2.0-S0378437108009849-main.pdf: 2320182 bytes, checksum: 564ad13087eb10af07fe823f607ad2da (MD5)Approved for entry into archive by Rodrigo Meirelles(rodrigomei@ufba.br) on 2013-10-15T15:11:41Z (GMT) No. of bitstreams: 1 1-s2.0-S0378437108009849-main.pdf: 2320182 bytes, checksum: 564ad13087eb10af07fe823f607ad2da (MD5)Made available in DSpace on 2013-10-15T15:11:41Z (GMT). No. of bitstreams: 1 1-s2.0-S0378437108009849-main.pdf: 2320182 bytes, checksum: 564ad13087eb10af07fe823f607ad2da (MD5) Previous issue date: 2009http://dx.doi.org/10.1016/j.physa.2008.11.038reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBATumor growthCellular automataParameter spaceNecrosisTherapyA cellular automata model for avascular solid tumor growth under the effect of therapyPhysica A: Statistical Mechanics and its Applicationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL1-s2.0-S0378437108009849-main.pdf1-s2.0-S0378437108009849-main.pdfapplication/pdf2320182https://repositorio.ufba.br/bitstream/ri/13216/1/1-s2.0-S0378437108009849-main.pdf564ad13087eb10af07fe823f607ad2daMD51LICENSElicense.txtlicense.txttext/plain1365https://repositorio.ufba.br/bitstream/ri/13216/2/license.txt5371a150bdc863f78dcf39281543bd86MD52TEXT1-s2.0-S0378437108009849-main.pdf.txt1-s2.0-S0378437108009849-main.pdf.txtExtracted texttext/plain36930https://repositorio.ufba.br/bitstream/ri/13216/3/1-s2.0-S0378437108009849-main.pdf.txtcd1d5580f2b453b8e40fc193a062ac47MD53ri/132162022-07-05 14:03:48.203oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:48Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
A cellular automata model for avascular solid tumor growth under the effect of therapy |
dc.title.alternative.pt_BR.fl_str_mv |
Physica A: Statistical Mechanics and its Applications |
title |
A cellular automata model for avascular solid tumor growth under the effect of therapy |
spellingShingle |
A cellular automata model for avascular solid tumor growth under the effect of therapy Reis, E. A. Tumor growth Cellular automata Parameter space Necrosis Therapy |
title_short |
A cellular automata model for avascular solid tumor growth under the effect of therapy |
title_full |
A cellular automata model for avascular solid tumor growth under the effect of therapy |
title_fullStr |
A cellular automata model for avascular solid tumor growth under the effect of therapy |
title_full_unstemmed |
A cellular automata model for avascular solid tumor growth under the effect of therapy |
title_sort |
A cellular automata model for avascular solid tumor growth under the effect of therapy |
author |
Reis, E. A. |
author_facet |
Reis, E. A. Santos, L. B. L. Pinho, Suani Tavares Rubim de |
author_role |
author |
author2 |
Santos, L. B. L. Pinho, Suani Tavares Rubim de |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Reis, E. A. Santos, L. B. L. Pinho, Suani Tavares Rubim de Reis, E. A. Santos, L. B. L. Pinho, Suani Tavares Rubim de |
dc.subject.por.fl_str_mv |
Tumor growth Cellular automata Parameter space Necrosis Therapy |
topic |
Tumor growth Cellular automata Parameter space Necrosis Therapy |
description |
Texto completo: acesso restrito. p. 1303-1314 |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2013-10-15T15:11:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufba.br/ri/handle/ri/13216 |
dc.identifier.issn.none.fl_str_mv |
0378-4371 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 388, n. 7 |
identifier_str_mv |
0378-4371 v. 388, n. 7 |
url |
http://www.repositorio.ufba.br/ri/handle/ri/13216 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.source.pt_BR.fl_str_mv |
http://dx.doi.org/10.1016/j.physa.2008.11.038 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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Universidade Federal da Bahia (UFBA) |
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UFBA |
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Repositório Institucional da UFBA |
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