a-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis

Detalhes bibliográficos
Autor(a) principal: Couto, Fábio David
Data de Publicação: 2003
Outros Autores: Albuquerque, Arlete Barreto Lins de, Adorno, Elisângela Vitória, Moura Neto, José Pereira de, Abbehusen, Luciana de Freitas, Oliveira, J. L. B. de, Reis, M. G. dos, Gonçalves, M. de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7322
Resumo: Texto Completo: acesso restrito. p. 29–34
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spelling Couto, Fábio DavidAlbuquerque, Arlete Barreto Lins deAdorno, Elisângela VitóriaMoura Neto, José Pereira deAbbehusen, Luciana de FreitasOliveira, J. L. B. deReis, M. G. dosGonçalves, M. de SouzaCouto, Fábio DavidAlbuquerque, Arlete Barreto Lins deAdorno, Elisângela VitóriaMoura Neto, José Pereira deAbbehusen, Luciana de FreitasOliveira, J. L. B. deReis, M. G. dosGonçalves, M. de Souza2012-12-07T14:50:36Z20030141-9854http://www.repositorio.ufba.br/ri/handle/ri/7322v. 25, n. 1Texto Completo: acesso restrito. p. 29–34a-Thalassemia is a synthesis hemoglobinopathy with a worldwide distribution. a-thalassemia- 23.7kb (a-Thal23.7kb) was investigated by PCR and standard hematologic analysis techniques in 106 pregnant women – 53 heterozygous for hemoglobin (Hb) A and C (AC) and 53 homozygous for the normal Hb A (AA) with similar ages and race ancestry. Eleven (21%) of AC women were a-Thal23.7kb heterozygous and 1 (2%) was homozygous, while 12 AA women (23%) were heterozygous. In the AA group, the MCV differed among those with normal a genes and those with a-Thal23.7kb (P ¼ 0.031). Statistical analysis of AC group patients with normal a genes and a-Thal23.7kb carriers showed differences in MCV (P ¼ 0.001); MCH (P ¼ 0.003) and Hb C concentrations (P ¼ 0.011). Analysis of AA and AC group patients with normal a genes showed differences in RBC (P ¼ 0.033), Hb concentration (P ¼ 0.003) and MCHC (P < 0.0001). There were no statistically significant differences for any hematologic parameters between AC and AA group patients with the a-Thal23.7kb genotype. The AC a-Thal23.7kb homozygous women had low hematologic parameters. Serum ferritin levels were normal among the groups studied. These results emphasize the importance of diagnosis and follow-up of patients with hemoglobinopathy carriers during pregnancy in order to administer adequate therapy and avoid further complications for mothers and newborns. Keywords Hemoglobinopathies, hemoglobin C, pregnancy.Submitted by Reis Suelen (suelen_suzane@hotmail.com) on 2012-12-07T14:50:36Z No. of bitstreams: 1 j.1365-2257.2003.00487.x.pdf: 180756 bytes, checksum: 6cc9ee5e35c50e2b235bb71f10a968d5 (MD5)Made available in DSpace on 2012-12-07T14:50:36Z (GMT). No. of bitstreams: 1 j.1365-2257.2003.00487.x.pdf: 180756 bytes, checksum: 6cc9ee5e35c50e2b235bb71f10a968d5 (MD5) Previous issue date: 2003http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2257.2003.00487.x/pdfreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHemoglobinopathiesHemoglobin CPregnancyThalassemiaHematologic parametersa-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysisClinical and Laboratory Haematologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALj.1365-2257.2003.00487.x.pdfj.1365-2257.2003.00487.x.pdfapplication/pdf180756https://repositorio.ufba.br/bitstream/ri/7322/1/j.1365-2257.2003.00487.x.pdf6cc9ee5e35c50e2b235bb71f10a968d5MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7322/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTj.1365-2257.2003.00487.x.pdf.txtj.1365-2257.2003.00487.x.pdf.txtExtracted texttext/plain24047https://repositorio.ufba.br/bitstream/ri/7322/3/j.1365-2257.2003.00487.x.pdf.txta585d40fbdc5342b30c6285fd65f88ceMD53ri/73222022-07-05 14:03:35.151oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:35Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv a-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis
dc.title.alternative.pt_BR.fl_str_mv Clinical and Laboratory Haematology
title a-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis
spellingShingle a-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis
Couto, Fábio David
Hemoglobinopathies
Hemoglobin C
Pregnancy
Thalassemia
Hematologic parameters
title_short a-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis
title_full a-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis
title_fullStr a-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis
title_full_unstemmed a-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis
title_sort a-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis
author Couto, Fábio David
author_facet Couto, Fábio David
Albuquerque, Arlete Barreto Lins de
Adorno, Elisângela Vitória
Moura Neto, José Pereira de
Abbehusen, Luciana de Freitas
Oliveira, J. L. B. de
Reis, M. G. dos
Gonçalves, M. de Souza
author_role author
author2 Albuquerque, Arlete Barreto Lins de
Adorno, Elisângela Vitória
Moura Neto, José Pereira de
Abbehusen, Luciana de Freitas
Oliveira, J. L. B. de
Reis, M. G. dos
Gonçalves, M. de Souza
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Couto, Fábio David
Albuquerque, Arlete Barreto Lins de
Adorno, Elisângela Vitória
Moura Neto, José Pereira de
Abbehusen, Luciana de Freitas
Oliveira, J. L. B. de
Reis, M. G. dos
Gonçalves, M. de Souza
Couto, Fábio David
Albuquerque, Arlete Barreto Lins de
Adorno, Elisângela Vitória
Moura Neto, José Pereira de
Abbehusen, Luciana de Freitas
Oliveira, J. L. B. de
Reis, M. G. dos
Gonçalves, M. de Souza
dc.subject.por.fl_str_mv Hemoglobinopathies
Hemoglobin C
Pregnancy
Thalassemia
Hematologic parameters
topic Hemoglobinopathies
Hemoglobin C
Pregnancy
Thalassemia
Hematologic parameters
description Texto Completo: acesso restrito. p. 29–34
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2012-12-07T14:50:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7322
dc.identifier.issn.none.fl_str_mv 0141-9854
dc.identifier.number.pt_BR.fl_str_mv v. 25, n. 1
identifier_str_mv 0141-9854
v. 25, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/7322
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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