IL6 −174 G/C Promoter Polymorphism Influences Susceptibility to Mucosal but Not Localized Cutaneous Leishmaniasis in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2006 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/12395 |
Resumo: | Texto completo: acesso restrito. P.519-527 |
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Castellucci, LéaMenezes, ElianeOliveira, JoyceMagalhães, AndreaGuimarães, Luiz HenriqueLessa, MarcusRibeiro, SilvanaReale, JeancarloNoronha, Elza FerreiraWilson, Mary E.Duggal, PriyaBeaty, Terri H.Jerônimo, SelmaBales, AshleeBlackwell, Jenefer M.Castellucci, LéaMenezes, ElianeOliveira, JoyceMagalhães, AndreaGuimarães, Luiz HenriqueLessa, MarcusRibeiro, SilvanaReale, JeancarloNoronha, Elza FerreiraWilson, Mary E.Duggal, PriyaBeaty, Terri H.Jerônimo, SelmaBales, AshleeBlackwell, Jenefer M.2013-08-01T11:16:27Z20061537-6613http://www.repositorio.ufba.br/ri/handle/ri/12395v.194 n. 4Texto completo: acesso restrito. P.519-527Background. Mucosal leishmaniasis (ML) is associated with exaggerated tumor necrosis factor–a and interferon- g responses and tissue destruction. ML follows localized cutaneous leishmaniasis (CL) caused by Leishmania braziliensis infection. Interleukin (IL)–6 down-regulates T helper (Th) cell type 1 differentiation and drives Th2 cell differentiation. The IL6 174 G/C polymorphism is associated with proinflammatory diseases and IL-6 regulation. Methods. The 174 G/C polymorphism was genotyped in population samples and families with CL and ML from Brazil. Genotype frequencies were compared among patients with ML, patients with CL, and 2 control groups by logistic regression and family-based association test (FBAT) analysis. IL-6 levels were measured in macrophages. Results. The C allele was more common in patients with ML than in patients with CL (odds ratio [OR], 2.55 [95% confidence interval {CI}, 1.32–4.91]; Pp.005), than in patients who were leishmanin skin-test positive (OR, 2.23 [95% CI, 1.23–4.05]; Pp.009), and than in neighborhood control subjects (OR, 2.47 [95% CI, 1.24–4.90]; Pp.01). FBAT analysis confirmed an association between allele C and ML under both additive (zp4.295; Pp.000017) and dominant (zp4.325; Pp.000015) models. Significantly lower levels of IL-6 were measured in unstimulated macrophages from CC individuals than from GG individuals (Pp.003) as well as after stimulation with soluble leishmania antigen (Pp.009). Conclusions. IL-6 may regulate type 1 proinflammatory responses, putting individuals with low macrophage IL-6 levels at increased risk for ML.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-08-01T11:16:27Z No. of bitstreams: 1 519.full.pdf: 153600 bytes, checksum: a0111b9185705e02d6f41206b695585e (MD5)Made available in DSpace on 2013-08-01T11:16:27Z (GMT). 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| dc.title.pt_BR.fl_str_mv |
IL6 −174 G/C Promoter Polymorphism Influences Susceptibility to Mucosal but Not Localized Cutaneous Leishmaniasis in Brazil |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Infectious Diseases |
| title |
IL6 −174 G/C Promoter Polymorphism Influences Susceptibility to Mucosal but Not Localized Cutaneous Leishmaniasis in Brazil |
| spellingShingle |
IL6 −174 G/C Promoter Polymorphism Influences Susceptibility to Mucosal but Not Localized Cutaneous Leishmaniasis in Brazil Castellucci, Léa |
| title_short |
IL6 −174 G/C Promoter Polymorphism Influences Susceptibility to Mucosal but Not Localized Cutaneous Leishmaniasis in Brazil |
| title_full |
IL6 −174 G/C Promoter Polymorphism Influences Susceptibility to Mucosal but Not Localized Cutaneous Leishmaniasis in Brazil |
| title_fullStr |
IL6 −174 G/C Promoter Polymorphism Influences Susceptibility to Mucosal but Not Localized Cutaneous Leishmaniasis in Brazil |
| title_full_unstemmed |
IL6 −174 G/C Promoter Polymorphism Influences Susceptibility to Mucosal but Not Localized Cutaneous Leishmaniasis in Brazil |
| title_sort |
IL6 −174 G/C Promoter Polymorphism Influences Susceptibility to Mucosal but Not Localized Cutaneous Leishmaniasis in Brazil |
| author |
Castellucci, Léa |
| author_facet |
Castellucci, Léa Menezes, Eliane Oliveira, Joyce Magalhães, Andrea Guimarães, Luiz Henrique Lessa, Marcus Ribeiro, Silvana Reale, Jeancarlo Noronha, Elza Ferreira Wilson, Mary E. Duggal, Priya Beaty, Terri H. Jerônimo, Selma Bales, Ashlee Blackwell, Jenefer M. |
| author_role |
author |
| author2 |
Menezes, Eliane Oliveira, Joyce Magalhães, Andrea Guimarães, Luiz Henrique Lessa, Marcus Ribeiro, Silvana Reale, Jeancarlo Noronha, Elza Ferreira Wilson, Mary E. Duggal, Priya Beaty, Terri H. Jerônimo, Selma Bales, Ashlee Blackwell, Jenefer M. |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Castellucci, Léa Menezes, Eliane Oliveira, Joyce Magalhães, Andrea Guimarães, Luiz Henrique Lessa, Marcus Ribeiro, Silvana Reale, Jeancarlo Noronha, Elza Ferreira Wilson, Mary E. Duggal, Priya Beaty, Terri H. Jerônimo, Selma Bales, Ashlee Blackwell, Jenefer M. Castellucci, Léa Menezes, Eliane Oliveira, Joyce Magalhães, Andrea Guimarães, Luiz Henrique Lessa, Marcus Ribeiro, Silvana Reale, Jeancarlo Noronha, Elza Ferreira Wilson, Mary E. Duggal, Priya Beaty, Terri H. Jerônimo, Selma Bales, Ashlee Blackwell, Jenefer M. |
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Texto completo: acesso restrito. P.519-527 |
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2006 |
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2006 |
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2013-08-01T11:16:27Z |
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1537-6613 |
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v.194 n. 4 |
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1537-6613 v.194 n. 4 |
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http://www.repositorio.ufba.br/ri/handle/ri/12395 |
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