Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion

Detalhes bibliográficos
Autor(a) principal: Lima, Josilene B. T.
Data de Publicação: 2010
Outros Autores: Ribeiro, Guilherme S., Cordeiro, Soraia Machado, Gouveia, Edilane L., Salgado, Kaátia, Reis, Mitermayer G., Ko, Albert I., Reis, Joice N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12094
Resumo: Texto completo: acesso restrito. p.1577-1584
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spelling Lima, Josilene B. T.Ribeiro, Guilherme S.Cordeiro, Soraia MachadoGouveia, Edilane L.Salgado, KaátiaReis, Mitermayer G.Ko, Albert I.Reis, Joice N.Lima, Josilene B. T.Ribeiro, Guilherme S.Cordeiro, Soraia MachadoGouveia, Edilane L.Salgado, KaátiaReis, Mitermayer G.Ko, Albert I.Reis, Joice N.2013-07-04T12:33:27Z20100022-1899http://www.repositorio.ufba.br/ri/handle/ri/12094v. 202, n. 10Texto completo: acesso restrito. p.1577-1584Since the introduction of Haemophilus influenzae type b (Hib) conjugate vaccines, meningitis caused by serotypes other than Hib has gained in importance. We conducted active hospital-based surveillance for meningitis over an 11-year period in Salvador, Brazil. H. influenzae isolates were serotyped and analyzed by polymerase chain reaction, pulsed-field gel electrophoresis, and DNA sequencing to identify strains with a specific deletion (IS1016) in the bexA gene (IS1016-bexA). We identified 43 meningitis cases caused by non-type b H. influenzae: 28 (65%) were caused by type a (Hia), 9 (21%) were caused by noncapsulated strains, and 3 (7%) each were caused by types e and f. Hia isolates clustered in 2 clonal groups; clonal group A strains (n = 9) had the IS1016-bexA deletion. Among children <5 years of age, meningitis caused by Hia from clonal group A had higher case-fatality than meningitis caused by clonal group B. Despite small numbers, these results indicate that the presence of the IS1016-bexA deletion is associated with enhanced virulence in non-type b H. influenzae.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-07-04T12:33:27Z No. of bitstreams: 1 J Infect Dis.-2010-Lima-1577-84.pdf: 1684946 bytes, checksum: f362da267d0e82836f5169d057750652 (MD5)Made available in DSpace on 2013-07-04T12:33:27Z (GMT). No. of bitstreams: 1 J Infect Dis.-2010-Lima-1577-84.pdf: 1684946 bytes, checksum: f362da267d0e82836f5169d057750652 (MD5) Previous issue date: 2010http://dx.doi.org/10.1086/656778reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAPoor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletionJournal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALJ Infect Dis.-2010-Lima-1577-84.pdfJ Infect Dis.-2010-Lima-1577-84.pdfapplication/pdf1684946https://repositorio.ufba.br/bitstream/ri/12094/1/J%20Infect%20Dis.-2010-Lima-1577-84.pdff362da267d0e82836f5169d057750652MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12094/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTJ Infect Dis.-2010-Lima-1577-84.pdf.txtJ Infect Dis.-2010-Lima-1577-84.pdf.txtExtracted texttext/plain34384https://repositorio.ufba.br/bitstream/ri/12094/3/J%20Infect%20Dis.-2010-Lima-1577-84.pdf.txt3c915a6096f810c92b8bfb281c661f67MD53ri/120942022-07-05 14:02:51.614oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:51Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
dc.title.alternative.pt_BR.fl_str_mv Journal of Infectious Diseases
title Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
spellingShingle Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
Lima, Josilene B. T.
title_short Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
title_full Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
title_fullStr Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
title_full_unstemmed Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
title_sort Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
author Lima, Josilene B. T.
author_facet Lima, Josilene B. T.
Ribeiro, Guilherme S.
Cordeiro, Soraia Machado
Gouveia, Edilane L.
Salgado, Kaátia
Reis, Mitermayer G.
Ko, Albert I.
Reis, Joice N.
author_role author
author2 Ribeiro, Guilherme S.
Cordeiro, Soraia Machado
Gouveia, Edilane L.
Salgado, Kaátia
Reis, Mitermayer G.
Ko, Albert I.
Reis, Joice N.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Josilene B. T.
Ribeiro, Guilherme S.
Cordeiro, Soraia Machado
Gouveia, Edilane L.
Salgado, Kaátia
Reis, Mitermayer G.
Ko, Albert I.
Reis, Joice N.
Lima, Josilene B. T.
Ribeiro, Guilherme S.
Cordeiro, Soraia Machado
Gouveia, Edilane L.
Salgado, Kaátia
Reis, Mitermayer G.
Ko, Albert I.
Reis, Joice N.
description Texto completo: acesso restrito. p.1577-1584
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2013-07-04T12:33:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12094
dc.identifier.issn.none.fl_str_mv 0022-1899
dc.identifier.number.pt_BR.fl_str_mv v. 202, n. 10
identifier_str_mv 0022-1899
v. 202, n. 10
url http://www.repositorio.ufba.br/ri/handle/ri/12094
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1086/656778
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