African Ancestry is a Risk Factor for Asthma and High Total IgE Levels in African Admixed Populations
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/17567 |
Resumo: | Texto completo: acesso restrito. p. 393–401 |
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Vergara, CandelariaMurray, TandaRafaels, Nicholas M.Lewis, RachelCampbell, MonicaFoster, CassandraGao, LiFaruque, MezbahOliveira, Ricardo RiccioCarvalho Filho, Edgar Marcelino deAraujo, Maria Ilma Andrade SantosCruz Filho, Álvaro Augusto Souza daWatson, HaroldMercado, DiliaRuczinski, IngoDunston, GeorgiaFord, JeanCaraballo, LuisBeaty, Terri H.Mathias, Rasika A.Barnes, Kathleen C.Knight-Madden, Jennifer2015-05-05T16:06:05Z20130741-0395http://repositorio.ufba.br/ri/handle/ri/17567v. 37, n. 4Texto completo: acesso restrito. p. 393–401Characterization of genetic admixture of populations in the Americas and the Caribbean is of interest for anthropological, epidemiological, and historical reasons. Asthma has a higher prevalence and is more severe in populations with a high African component. Association of African ancestry with asthma has been demonstrated. We estimated admixture proportions of samples from six trihybrid populations of African descent and determined the relationship between African ancestry and asthma and total serum IgE levels (tIgE). We genotyped 237 ancestry informative markers in asthmatics and nonasthmatic controls from Barbados (190/277), Jamaica (177/529), Brazil (40/220), Colombia (508/625), African Americans from New York (207/171), and African Americans from Baltimore/Washington, D.C. (625/757). We estimated individual ancestries and evaluated genetic stratification using Structure and principal component analysis. Association of African ancestry and asthma and tIgE was evaluated by regression analysis. Mean ± SD African ancestry ranged from 0.76 ± 0.10 among Barbadians to 0.33 ± 0.13 in Colombians. The European component varied from 0.14 ± 0.05 among Jamaicans and Barbadians to 0.26 ± 0.08 among Colombians. African ancestry was associated with risk for asthma in Colombians (odds ratio (OR) = 4.5, P = 0.001) Brazilians (OR = 136.5, P = 0.003), and African Americans of New York (OR: 4.7; P = 0.040). African ancestry was also associated with higher tIgE levels among Colombians (β = 1.3, P = 0.04), Barbadians (β = 3.8, P = 0.03), and Brazilians (β = 1.6, P = 0.03). Our findings indicate that African ancestry can account for, at least in part, the association between asthma and its associated trait, tIgE levels.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-11-19T11:41:52Z No. of bitstreams: 1 Candelaria Vergara.pdf: 683776 bytes, checksum: 3f244a5ee46560431d06949a67843bd9 (MD5)Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2015-05-05T16:06:05Z (GMT) No. of bitstreams: 1 Candelaria Vergara.pdf: 683776 bytes, checksum: 3f244a5ee46560431d06949a67843bd9 (MD5)Made available in DSpace on 2015-05-05T16:06:05Z (GMT). No. of bitstreams: 1 Candelaria Vergara.pdf: 683776 bytes, checksum: 3f244a5ee46560431d06949a67843bd9 (MD5) Previous issue date: 2013http://dx.doi.org/10.1002/gepi.21702reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAfricanAsthmaAncestryAfrican Ancestry is a Risk Factor for Asthma and High Total IgE Levels in African Admixed PopulationsGenetic Epidemiologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALCandelaria Vergara.pdfCandelaria Vergara.pdfapplication/pdf683776https://repositorio.ufba.br/bitstream/ri/17567/1/Candelaria%20Vergara.pdf3f244a5ee46560431d06949a67843bd9MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/17567/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTCandelaria Vergara.pdf.txtCandelaria Vergara.pdf.txtExtracted texttext/plain55753https://repositorio.ufba.br/bitstream/ri/17567/3/Candelaria%20Vergara.pdf.txta1ca67ae10eb4b612f17fc4bef488e14MD53ri/175672022-07-01 10:46:54.256oai:repositorio.ufba.br:ri/17567VGVybW8gZGUgTGljZW7vv71hLCBu77+9byBleGNsdXNpdm8sIHBhcmEgbyBkZXDvv71zaXRvIG5vIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRkJBLgoKIFBlbG8gcHJvY2Vzc28gZGUgc3VibWlzc++/vW8gZGUgZG9jdW1lbnRvcywgbyBhdXRvciBvdSBzZXUgcmVwcmVzZW50YW50ZSBsZWdhbCwgYW8gYWNlaXRhciAKZXNzZSB0ZXJtbyBkZSBsaWNlbu+/vWEsIGNvbmNlZGUgYW8gUmVwb3NpdO+/vXJpbyBJbnN0aXR1Y2lvbmFsIGRhIFVuaXZlcnNpZGFkZSBGZWRlcmFsIGRhIEJhaGlhIApvIGRpcmVpdG8gZGUgbWFudGVyIHVtYSBj77+9cGlhIGVtIHNldSByZXBvc2l077+9cmlvIGNvbSBhIGZpbmFsaWRhZGUsIHByaW1laXJhLCBkZSBwcmVzZXJ2Ye+/ve+/vW8uIApFc3NlcyB0ZXJtb3MsIG7vv71vIGV4Y2x1c2l2b3MsIG1hbnTvv71tIG9zIGRpcmVpdG9zIGRlIGF1dG9yL2NvcHlyaWdodCwgbWFzIGVudGVuZGUgbyBkb2N1bWVudG8gCmNvbW8gcGFydGUgZG8gYWNlcnZvIGludGVsZWN0dWFsIGRlc3NhIFVuaXZlcnNpZGFkZS4KCiBQYXJhIG9zIGRvY3VtZW50b3MgcHVibGljYWRvcyBjb20gcmVwYXNzZSBkZSBkaXJlaXRvcyBkZSBkaXN0cmlidWnvv73vv71vLCBlc3NlIHRlcm1vIGRlIGxpY2Vu77+9YSAKZW50ZW5kZSBxdWU6CgogTWFudGVuZG8gb3MgZGlyZWl0b3MgYXV0b3JhaXMsIHJlcGFzc2Fkb3MgYSB0ZXJjZWlyb3MsIGVtIGNhc28gZGUgcHVibGljYe+/ve+/vWVzLCBvIHJlcG9zaXTvv71yaW8KcG9kZSByZXN0cmluZ2lyIG8gYWNlc3NvIGFvIHRleHRvIGludGVncmFsLCBtYXMgbGliZXJhIGFzIGluZm9ybWHvv73vv71lcyBzb2JyZSBvIGRvY3VtZW50bwooTWV0YWRhZG9zIGVzY3JpdGl2b3MpLgoKIERlc3RhIGZvcm1hLCBhdGVuZGVuZG8gYW9zIGFuc2Vpb3MgZGVzc2EgdW5pdmVyc2lkYWRlIGVtIG1hbnRlciBzdWEgcHJvZHXvv73vv71vIGNpZW5077+9ZmljYSBjb20gCmFzIHJlc3Ryae+/ve+/vWVzIGltcG9zdGFzIHBlbG9zIGVkaXRvcmVzIGRlIHBlcmnvv71kaWNvcy4KCiBQYXJhIGFzIHB1YmxpY2Hvv73vv71lcyBzZW0gaW5pY2lhdGl2YXMgcXVlIHNlZ3VlbSBhIHBvbO+/vXRpY2EgZGUgQWNlc3NvIEFiZXJ0bywgb3MgZGVw77+9c2l0b3MgCmNvbXB1bHPvv71yaW9zIG5lc3NlIHJlcG9zaXTvv71yaW8gbWFudO+/vW0gb3MgZGlyZWl0b3MgYXV0b3JhaXMsIG1hcyBtYW5077+9bSBhY2Vzc28gaXJyZXN0cml0byAKYW8gbWV0YWRhZG9zIGUgdGV4dG8gY29tcGxldG8uIEFzc2ltLCBhIGFjZWl0Ye+/ve+/vW8gZGVzc2UgdGVybW8gbu+/vW8gbmVjZXNzaXRhIGRlIGNvbnNlbnRpbWVudG8KIHBvciBwYXJ0ZSBkZSBhdXRvcmVzL2RldGVudG9yZXMgZG9zIGRpcmVpdG9zLCBwb3IgZXN0YXJlbSBlbSBpbmljaWF0aXZhcyBkZSBhY2Vzc28gYWJlcnRvLgo=Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-01T13:46:54Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
African Ancestry is a Risk Factor for Asthma and High Total IgE Levels in African Admixed Populations |
| dc.title.alternative.pt_BR.fl_str_mv |
Genetic Epidemiology |
| title |
African Ancestry is a Risk Factor for Asthma and High Total IgE Levels in African Admixed Populations |
| spellingShingle |
African Ancestry is a Risk Factor for Asthma and High Total IgE Levels in African Admixed Populations Vergara, Candelaria African Asthma Ancestry |
| title_short |
African Ancestry is a Risk Factor for Asthma and High Total IgE Levels in African Admixed Populations |
| title_full |
African Ancestry is a Risk Factor for Asthma and High Total IgE Levels in African Admixed Populations |
| title_fullStr |
African Ancestry is a Risk Factor for Asthma and High Total IgE Levels in African Admixed Populations |
| title_full_unstemmed |
African Ancestry is a Risk Factor for Asthma and High Total IgE Levels in African Admixed Populations |
| title_sort |
African Ancestry is a Risk Factor for Asthma and High Total IgE Levels in African Admixed Populations |
| author |
Vergara, Candelaria |
| author_facet |
Vergara, Candelaria Murray, Tanda Rafaels, Nicholas M. Lewis, Rachel Campbell, Monica Foster, Cassandra Gao, Li Faruque, Mezbah Oliveira, Ricardo Riccio Carvalho Filho, Edgar Marcelino de Araujo, Maria Ilma Andrade Santos Cruz Filho, Álvaro Augusto Souza da Watson, Harold Mercado, Dilia Ruczinski, Ingo Dunston, Georgia Ford, Jean Caraballo, Luis Beaty, Terri H. Mathias, Rasika A. Barnes, Kathleen C. Knight-Madden, Jennifer |
| author_role |
author |
| author2 |
Murray, Tanda Rafaels, Nicholas M. Lewis, Rachel Campbell, Monica Foster, Cassandra Gao, Li Faruque, Mezbah Oliveira, Ricardo Riccio Carvalho Filho, Edgar Marcelino de Araujo, Maria Ilma Andrade Santos Cruz Filho, Álvaro Augusto Souza da Watson, Harold Mercado, Dilia Ruczinski, Ingo Dunston, Georgia Ford, Jean Caraballo, Luis Beaty, Terri H. Mathias, Rasika A. Barnes, Kathleen C. Knight-Madden, Jennifer |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Vergara, Candelaria Murray, Tanda Rafaels, Nicholas M. Lewis, Rachel Campbell, Monica Foster, Cassandra Gao, Li Faruque, Mezbah Oliveira, Ricardo Riccio Carvalho Filho, Edgar Marcelino de Araujo, Maria Ilma Andrade Santos Cruz Filho, Álvaro Augusto Souza da Watson, Harold Mercado, Dilia Ruczinski, Ingo Dunston, Georgia Ford, Jean Caraballo, Luis Beaty, Terri H. Mathias, Rasika A. Barnes, Kathleen C. Knight-Madden, Jennifer |
| dc.subject.por.fl_str_mv |
African Asthma Ancestry |
| topic |
African Asthma Ancestry |
| description |
Texto completo: acesso restrito. p. 393–401 |
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2013 |
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2013 |
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2015-05-05T16:06:05Z |
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0741-0395 |
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v. 37, n. 4 |
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0741-0395 v. 37, n. 4 |
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