African biogeographical ancestry, atopic and non-atopic asthma and atopy: A study in Latin American children

Detalhes bibliográficos
Autor(a) principal: Silva, Thiago Magalhães da
Data de Publicação: 2019
Outros Autores: Fiaccone, Rosemeire Leovigildo, Kehdy, Fernanda de Souza Gomes, Santos, Eduardo Tarazona, Rodrigues, Laura Cunha, Costa, Gustavo Nunes de Oliveira, Figueiredo, Camila Alexandrina de, Santos, Darci Neves dos, Feitosa, Caroline Alves, Fattore, Gisel Lorena, Santos, Leticia Marques dos, Neves, Neuza Maria Alcantara, Cruz, Álvaro Augusto, Barreto, Maurício Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31403
Resumo: Department of Science and Technology (DECIT, Ministry of Health); National Fund for Scientific and Technological Development (FNDCT, Ministry of Science and Technology); (FINEP, Ministry of Science and Technology, Brazil)
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spelling Silva, Thiago Magalhães daFiaccone, Rosemeire LeovigildoKehdy, Fernanda de Souza GomesSantos, Eduardo TarazonaRodrigues, Laura CunhaCosta, Gustavo Nunes de OliveiraFigueiredo, Camila Alexandrina deSantos, Darci Neves dosFeitosa, Caroline AlvesFattore, Gisel LorenaSantos, Leticia Marques dosNeves, Neuza Maria AlcantaraCruz, Álvaro AugustoBarreto, Maurício Lima2019-02-04T14:27:41Z2019-02-04T14:27:41Z2019SILVA, T. M. et al. African biogeographical ancestry, atopic and non-atopic asthma and atopy: A study in Latin American children. Pediatric Pulmonology, v. 54, p. 125–132, 2019.8755-6863https://www.arca.fiocruz.br/handle/icict/3140310.1002/ppul.24213Department of Science and Technology (DECIT, Ministry of Health); National Fund for Scientific and Technological Development (FNDCT, Ministry of Science and Technology); (FINEP, Ministry of Science and Technology, Brazil)Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil / Universidade Estadual do Sudoeste da Bahia. Departamento de Ciências Biológicas. Jequié, BA, Brasil.Universidade Federal da Bahia. Instituto de Matemática. Departamento de Estatística. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil.London School of Hygiene and Tropical Medicine. Faculty of Epidemiology. Department of Infectious Disease Epidemiology. London, United Kingdom.Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil.Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil.Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil / Universidad Nacional de Lanús. Departamento de Salud Comunitaria. Buenos Aires, Argentina.Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Federal University of Bahia. School of Medicine. ProAR-Center of Excellence in Asthma. Salvador, BA, Brazil.Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil.Genetic variants underlying African ancestry have been suggested be implicated in the ethnic-racial inequalities reported for asthma and allergies. Objectives: To investigate the association between individual African ancestry and asthma symptoms, atopic and non-atopic asthma, and atopy in children. Methods: A cross-sectional study encompassing 1190 individuals was conducted. African biogeographic ancestry was estimated using 370 539 genome-wide SNPs. Serum levels of specific IgE were measured, and skin prick test (SPT) performed for the most common local aeroallergens. Information on asthma symptoms was obtained by applying the International Study of Allergy and Asthma in Childhood questionnaire. The associations between the proportion of individual African ancestry and the outcomes investigated were analyzed through multivariate models adjusted for socio-environmental variables, infections markers, and psychosocial factors. Results: Each 20% increase in the proportion of African ancestry was negatively associated with SPT reactivity (OR: 0.79, 95%CI: 0.66-0.96) and positively associated with asthma symptoms in non-atopic individuals (OR: 1.40, 95%CI: 1.03-1.89). We estimated that socioeconomic status and number of infections mediated 28.4% of the effect of African ancestry on SPT reactivity, while 20.2% of the effect on non-atopic asthma was explained by socioeconomic status and behavioral problems in children. Conclusions: The negative association observed between African ancestry and atopy is most probably explained by unobserved environmental or social factors that covariate with ancestry. For non-atopic asthma, in turn, putative genetic variants of risk underlying African ancestry may play some role.engWileyAlergiaAsmaAscendência biogeográficaMediaçãoDesigualdades raciaisAllergyAsthmaBiogeographical ancestryMediationRacial inequalitiesAfrican biogeographical ancestry, atopic and non-atopic asthma and atopy: A study in Latin American childreninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31403/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSILVA, T.M. African biogeographical .... 2018.pdfSILVA, T.M. 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dc.title.pt_BR.fl_str_mv African biogeographical ancestry, atopic and non-atopic asthma and atopy: A study in Latin American children
title African biogeographical ancestry, atopic and non-atopic asthma and atopy: A study in Latin American children
spellingShingle African biogeographical ancestry, atopic and non-atopic asthma and atopy: A study in Latin American children
Silva, Thiago Magalhães da
Alergia
Asma
Ascendência biogeográfica
Mediação
Desigualdades raciais
Allergy
Asthma
Biogeographical ancestry
Mediation
Racial inequalities
title_short African biogeographical ancestry, atopic and non-atopic asthma and atopy: A study in Latin American children
title_full African biogeographical ancestry, atopic and non-atopic asthma and atopy: A study in Latin American children
title_fullStr African biogeographical ancestry, atopic and non-atopic asthma and atopy: A study in Latin American children
title_full_unstemmed African biogeographical ancestry, atopic and non-atopic asthma and atopy: A study in Latin American children
title_sort African biogeographical ancestry, atopic and non-atopic asthma and atopy: A study in Latin American children
author Silva, Thiago Magalhães da
author_facet Silva, Thiago Magalhães da
Fiaccone, Rosemeire Leovigildo
Kehdy, Fernanda de Souza Gomes
Santos, Eduardo Tarazona
Rodrigues, Laura Cunha
Costa, Gustavo Nunes de Oliveira
Figueiredo, Camila Alexandrina de
Santos, Darci Neves dos
Feitosa, Caroline Alves
Fattore, Gisel Lorena
Santos, Leticia Marques dos
Neves, Neuza Maria Alcantara
Cruz, Álvaro Augusto
Barreto, Maurício Lima
author_role author
author2 Fiaccone, Rosemeire Leovigildo
Kehdy, Fernanda de Souza Gomes
Santos, Eduardo Tarazona
Rodrigues, Laura Cunha
Costa, Gustavo Nunes de Oliveira
Figueiredo, Camila Alexandrina de
Santos, Darci Neves dos
Feitosa, Caroline Alves
Fattore, Gisel Lorena
Santos, Leticia Marques dos
Neves, Neuza Maria Alcantara
Cruz, Álvaro Augusto
Barreto, Maurício Lima
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Thiago Magalhães da
Fiaccone, Rosemeire Leovigildo
Kehdy, Fernanda de Souza Gomes
Santos, Eduardo Tarazona
Rodrigues, Laura Cunha
Costa, Gustavo Nunes de Oliveira
Figueiredo, Camila Alexandrina de
Santos, Darci Neves dos
Feitosa, Caroline Alves
Fattore, Gisel Lorena
Santos, Leticia Marques dos
Neves, Neuza Maria Alcantara
Cruz, Álvaro Augusto
Barreto, Maurício Lima
dc.subject.other.pt_BR.fl_str_mv Alergia
Asma
Ascendência biogeográfica
Mediação
Desigualdades raciais
topic Alergia
Asma
Ascendência biogeográfica
Mediação
Desigualdades raciais
Allergy
Asthma
Biogeographical ancestry
Mediation
Racial inequalities
dc.subject.en.pt_BR.fl_str_mv Allergy
Asthma
Biogeographical ancestry
Mediation
Racial inequalities
description Department of Science and Technology (DECIT, Ministry of Health); National Fund for Scientific and Technological Development (FNDCT, Ministry of Science and Technology); (FINEP, Ministry of Science and Technology, Brazil)
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-02-04T14:27:41Z
dc.date.available.fl_str_mv 2019-02-04T14:27:41Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, T. M. et al. African biogeographical ancestry, atopic and non-atopic asthma and atopy: A study in Latin American children. Pediatric Pulmonology, v. 54, p. 125–132, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31403
dc.identifier.issn.pt_BR.fl_str_mv 8755-6863
dc.identifier.doi.none.fl_str_mv 10.1002/ppul.24213
identifier_str_mv SILVA, T. M. et al. African biogeographical ancestry, atopic and non-atopic asthma and atopy: A study in Latin American children. Pediatric Pulmonology, v. 54, p. 125–132, 2019.
8755-6863
10.1002/ppul.24213
url https://www.arca.fiocruz.br/handle/icict/31403
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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