Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effects
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/22797 |
Resumo: | Key Words: Open-field. Swimming exercise. Morris water maze. Elevated plus-maze. Lithium. Object recognition. |
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Cruz, José Geraldo Pereira daLima, Daniela Delwing deDal Magro, Débora DelwingBernardes, Jaqueline RafaelaCruz, Julia Niehues daSouza, Larissa Hermann deCruz, José Geraldo Pereira daLima, Daniela Delwing deDal Magro, Débora DelwingBernardes, Jaqueline RafaelaCruz, Julia Niehues daSouza, Larissa Hermann de2017-06-05T19:07:21Z2017-06-05T19:07:21Z2011R. Ci. med. biol., Salvador, v.10, n.2, p.126-135, mai./ago. 20112236-5222http://repositorio.ufba.br/ri/handle/ri/22797v.10, n. 2Key Words: Open-field. Swimming exercise. Morris water maze. Elevated plus-maze. Lithium. Object recognition.Abstract Previous studies have indicated that chronic exercise mimics some of the central nervous system effects observed after antidepressant drug treatment. The purpose of this work was to investigate the possible effect of lithium treatment in mice swimmers in the animals models of anxiety and memory. The mice were evaluated at the elevated plus-maze, open-field, Morris water maze and object recognition. Adult male Swiss mice were divided in four groups: control sedentary (CS), lithium sedentary (LS), control swimming exercise (CE), and lithium swimming exercise (LE), treated either with normal chow or with chow containing with 0,25% lithium carbonate for 30 days. The results suggest that lithium treatment, swimming exercise or lithium treatment combined with swimming exercise induces an anxiolytic-like effect in mice in the elevated plus-maze test. These symptoms were observed in LS as an increase in time spent in the open arms and open arms entries (F = 3.238; p<0,05 and F = 4.093; p<0,05; respectively); while CE - LE showed an increase in time spent in the risk assessment (F = 17.644; p<0,001). The open-field tests indicated a reduction of fear and an increase in exploratory activity. The LS - CE reduced the time spent in the freezing (F = 3.274; p<0,05) and CE - LE increased the time spent in the exploratory activity (F = 9.149; p<0,001). Comparison within each group during the five days of Morris water maze test, showed a decrease of latency time of groups LS - CE from the second day of the testing (F = 21.512; p<0,001 and F = 3.688; p<0,001; respectively). In object recognition test, mice of group CE increased in exploration ratio in both short (STM) and long-term object recognition memory (LTM), when compared to CS (F = 9.246; p<0,001). The groups LS - LE did not differ significantly from CS (p>0,05). The present study found that swimming exercise and/or lithium treatment induced an anxiolytic-like effect, indicating that interactions between physical activity and/or lithium may be beneficial. However, the lithium treatment prevents the increase in learning and memory improvement induced by swimming exercise. The results provide evidence that stimulates investigation of the possibility that swimming exercise, in conjunction with lithium treatment, could represent a new approach to improvement of behavioral management in depression.Submitted by ROBERTO PAULO CORREIA DE ARAÚJO (ppgorgsistem@ufba.br) on 2017-06-05T19:07:21Z No. of bitstreams: 1 4_v.10_2.pdf: 329087 bytes, checksum: 49ac60838901b7c80b7adbcc26563e04 (MD5)Made available in DSpace on 2017-06-05T19:07:21Z (GMT). No. of bitstreams: 1 4_v.10_2.pdf: 329087 bytes, checksum: 49ac60838901b7c80b7adbcc26563e04 (MD5) Previous issue date: 2011-05SalvadorInstituto de Ciências da Saúde/ Universidade Federal da BahiaBrasilhttp://www.portalseer.ufba.br/index.php/cmbio/article/view/5259/4164reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACampo abertoExercício de nataçãoLabirinto aquático de MorrisLitioReconhecimento de objetos.Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effectsRevista de Ciências Médicas e Biológicasinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessporORIGINAL4_v.10_2.pdf4_v.10_2.pdfapplication/pdf329087https://repositorio.ufba.br/bitstream/ri/22797/1/4_v.10_2.pdf49ac60838901b7c80b7adbcc26563e04MD51LICENSElicense.txtlicense.txttext/plain1383https://repositorio.ufba.br/bitstream/ri/22797/2/license.txt05eca2f01d0b3307819d0369dab18a34MD52TEXT4_v.10_2.pdf.txt4_v.10_2.pdf.txtExtracted texttext/plain48982https://repositorio.ufba.br/bitstream/ri/22797/3/4_v.10_2.pdf.txt389fae81e45a52289ea72d17ca5048cbMD53ri/227972022-10-11 10:46:33.14oai:repositorio.ufba.br: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ório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-10-11T13:46:33Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effects |
dc.title.alternative.pt_BR.fl_str_mv |
Revista de Ciências Médicas e Biológicas |
title |
Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effects |
spellingShingle |
Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effects Cruz, José Geraldo Pereira da Campo aberto Exercício de natação Labirinto aquático de Morris Litio Reconhecimento de objetos. |
title_short |
Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effects |
title_full |
Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effects |
title_fullStr |
Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effects |
title_full_unstemmed |
Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effects |
title_sort |
Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effects |
author |
Cruz, José Geraldo Pereira da |
author_facet |
Cruz, José Geraldo Pereira da Lima, Daniela Delwing de Dal Magro, Débora Delwing Bernardes, Jaqueline Rafaela Cruz, Julia Niehues da Souza, Larissa Hermann de |
author_role |
author |
author2 |
Lima, Daniela Delwing de Dal Magro, Débora Delwing Bernardes, Jaqueline Rafaela Cruz, Julia Niehues da Souza, Larissa Hermann de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Cruz, José Geraldo Pereira da Lima, Daniela Delwing de Dal Magro, Débora Delwing Bernardes, Jaqueline Rafaela Cruz, Julia Niehues da Souza, Larissa Hermann de Cruz, José Geraldo Pereira da Lima, Daniela Delwing de Dal Magro, Débora Delwing Bernardes, Jaqueline Rafaela Cruz, Julia Niehues da Souza, Larissa Hermann de |
dc.subject.por.fl_str_mv |
Campo aberto Exercício de natação Labirinto aquático de Morris Litio Reconhecimento de objetos. |
topic |
Campo aberto Exercício de natação Labirinto aquático de Morris Litio Reconhecimento de objetos. |
description |
Key Words: Open-field. Swimming exercise. Morris water maze. Elevated plus-maze. Lithium. Object recognition. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2017-06-05T19:07:21Z |
dc.date.available.fl_str_mv |
2017-06-05T19:07:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
R. Ci. med. biol., Salvador, v.10, n.2, p.126-135, mai./ago. 2011 |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufba.br/ri/handle/ri/22797 |
dc.identifier.issn.none.fl_str_mv |
2236-5222 |
dc.identifier.number.pt_BR.fl_str_mv |
v.10, n. 2 |
identifier_str_mv |
R. Ci. med. biol., Salvador, v.10, n.2, p.126-135, mai./ago. 2011 2236-5222 v.10, n. 2 |
url |
http://repositorio.ufba.br/ri/handle/ri/22797 |
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por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Instituto de Ciências da Saúde/ Universidade Federal da Bahia |
dc.publisher.country.fl_str_mv |
Brasil |
publisher.none.fl_str_mv |
Instituto de Ciências da Saúde/ Universidade Federal da Bahia |
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http://www.portalseer.ufba.br/index.php/cmbio/article/view/5259/4164 |
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