Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effects

Detalhes bibliográficos
Autor(a) principal: Cruz, José Geraldo Pereira da
Data de Publicação: 2011
Outros Autores: Lima, Daniela Delwing de, Dal Magro, Débora Delwing, Bernardes, Jaqueline Rafaela, Cruz, Julia Niehues da, Souza, Larissa Hermann de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/22797
Resumo: Key Words: Open-field. Swimming exercise. Morris water maze. Elevated plus-maze. Lithium. Object recognition.
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spelling Cruz, José Geraldo Pereira daLima, Daniela Delwing deDal Magro, Débora DelwingBernardes, Jaqueline RafaelaCruz, Julia Niehues daSouza, Larissa Hermann deCruz, José Geraldo Pereira daLima, Daniela Delwing deDal Magro, Débora DelwingBernardes, Jaqueline RafaelaCruz, Julia Niehues daSouza, Larissa Hermann de2017-06-05T19:07:21Z2017-06-05T19:07:21Z2011R. Ci. med. biol., Salvador, v.10, n.2, p.126-135, mai./ago. 20112236-5222http://repositorio.ufba.br/ri/handle/ri/22797v.10, n. 2Key Words: Open-field. Swimming exercise. Morris water maze. Elevated plus-maze. Lithium. Object recognition.Abstract Previous studies have indicated that chronic exercise mimics some of the central nervous system effects observed after antidepressant drug treatment. The purpose of this work was to investigate the possible effect of lithium treatment in mice swimmers in the animals models of anxiety and memory. The mice were evaluated at the elevated plus-maze, open-field, Morris water maze and object recognition. Adult male Swiss mice were divided in four groups: control sedentary (CS), lithium sedentary (LS), control swimming exercise (CE), and lithium swimming exercise (LE), treated either with normal chow or with chow containing with 0,25% lithium carbonate for 30 days. The results suggest that lithium treatment, swimming exercise or lithium treatment combined with swimming exercise induces an anxiolytic-like effect in mice in the elevated plus-maze test. These symptoms were observed in LS as an increase in time spent in the open arms and open arms entries (F = 3.238; p<0,05 and F = 4.093; p<0,05; respectively); while CE - LE showed an increase in time spent in the risk assessment (F = 17.644; p<0,001). The open-field tests indicated a reduction of fear and an increase in exploratory activity. The LS - CE reduced the time spent in the freezing (F = 3.274; p<0,05) and CE - LE increased the time spent in the exploratory activity (F = 9.149; p<0,001). Comparison within each group during the five days of Morris water maze test, showed a decrease of latency time of groups LS - CE from the second day of the testing (F = 21.512; p<0,001 and F = 3.688; p<0,001; respectively). In object recognition test, mice of group CE increased in exploration ratio in both short (STM) and long-term object recognition memory (LTM), when compared to CS (F = 9.246; p<0,001). The groups LS - LE did not differ significantly from CS (p>0,05). The present study found that swimming exercise and/or lithium treatment induced an anxiolytic-like effect, indicating that interactions between physical activity and/or lithium may be beneficial. However, the lithium treatment prevents the increase in learning and memory improvement induced by swimming exercise. The results provide evidence that stimulates investigation of the possibility that swimming exercise, in conjunction with lithium treatment, could represent a new approach to improvement of behavioral management in depression.Submitted by ROBERTO PAULO CORREIA DE ARAÚJO (ppgorgsistem@ufba.br) on 2017-06-05T19:07:21Z No. of bitstreams: 1 4_v.10_2.pdf: 329087 bytes, checksum: 49ac60838901b7c80b7adbcc26563e04 (MD5)Made available in DSpace on 2017-06-05T19:07:21Z (GMT). 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dc.title.pt_BR.fl_str_mv Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effects
dc.title.alternative.pt_BR.fl_str_mv Revista de Ciências Médicas e Biológicas
title Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effects
spellingShingle Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effects
Cruz, José Geraldo Pereira da
Campo aberto
Exercício de natação
Labirinto aquático de Morris
Litio
Reconhecimento de objetos.
title_short Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effects
title_full Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effects
title_fullStr Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effects
title_full_unstemmed Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effects
title_sort Loss of memory induced by swimming exercise in mice treated with lithium and anxiolytic-like effects
author Cruz, José Geraldo Pereira da
author_facet Cruz, José Geraldo Pereira da
Lima, Daniela Delwing de
Dal Magro, Débora Delwing
Bernardes, Jaqueline Rafaela
Cruz, Julia Niehues da
Souza, Larissa Hermann de
author_role author
author2 Lima, Daniela Delwing de
Dal Magro, Débora Delwing
Bernardes, Jaqueline Rafaela
Cruz, Julia Niehues da
Souza, Larissa Hermann de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cruz, José Geraldo Pereira da
Lima, Daniela Delwing de
Dal Magro, Débora Delwing
Bernardes, Jaqueline Rafaela
Cruz, Julia Niehues da
Souza, Larissa Hermann de
Cruz, José Geraldo Pereira da
Lima, Daniela Delwing de
Dal Magro, Débora Delwing
Bernardes, Jaqueline Rafaela
Cruz, Julia Niehues da
Souza, Larissa Hermann de
dc.subject.por.fl_str_mv Campo aberto
Exercício de natação
Labirinto aquático de Morris
Litio
Reconhecimento de objetos.
topic Campo aberto
Exercício de natação
Labirinto aquático de Morris
Litio
Reconhecimento de objetos.
description Key Words: Open-field. Swimming exercise. Morris water maze. Elevated plus-maze. Lithium. Object recognition.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2017-06-05T19:07:21Z
dc.date.available.fl_str_mv 2017-06-05T19:07:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv R. Ci. med. biol., Salvador, v.10, n.2, p.126-135, mai./ago. 2011
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/22797
dc.identifier.issn.none.fl_str_mv 2236-5222
dc.identifier.number.pt_BR.fl_str_mv v.10, n. 2
identifier_str_mv R. Ci. med. biol., Salvador, v.10, n.2, p.126-135, mai./ago. 2011
2236-5222
v.10, n. 2
url http://repositorio.ufba.br/ri/handle/ri/22797
dc.language.iso.fl_str_mv por
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Instituto de Ciências da Saúde/ Universidade Federal da Bahia
dc.publisher.country.fl_str_mv Brasil
publisher.none.fl_str_mv Instituto de Ciências da Saúde/ Universidade Federal da Bahia
dc.source.pt_BR.fl_str_mv http://www.portalseer.ufba.br/index.php/cmbio/article/view/5259/4164
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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