NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5884 |
Resumo: | Acesso restrito: Texto completo. p. 469-475 |
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Reis, Eliana A. G.Athanazio, Daniel AbensurLima, IsabellaSilva, Natália Oliveira eAndrade, Jorge Clarencio SouzaJesus, Ronden Nunes deBarbosa, Lúcio MacedoReis, Mitermayer Galvão dosSantiago, Mittermayer BarretoReis, Eliana A. G.Athanazio, Daniel AbensurLima, IsabellaSilva, Natália Oliveira eAndrade, Jorge Clarencio SouzaJesus, Ronden Nunes deBarbosa, Lúcio MacedoReis, Mitermayer Galvão dosSantiago, Mittermayer Barreto2012-05-16T18:10:04Z20090172-8172http://www.repositorio.ufba.br/ri/handle/ri/5884v. 29, n. 4Acesso restrito: Texto completo. p. 469-475Biomarkers of clinical response to rituximab (RTX) therapy and early predictors of outcome are still under investigation. We report a Xow cytometric immunophenotyping analysis from peripheral blood leukocyte subpopulations of two patients with systemic lupus erythematosus (SLE) associated thrombocytopenia and one patient with rheumatoid arthritis (RA), before and after 6 weeks of treatment with RTX. Our results show a reduced population of CD19+ expressing cells (B cells) after RTX treatment in all three patients. Increased frequency of peripheral regulatory CD4+CD25high T cell subset and the CD3¡CD16¡CD56bright NK cell subset after RTX therapy were also observed in all patients, the latter being more pronounced in the SLE patient with sustained clinical response. In addition, an increased population of NKT cell subsets was observed in the patients with clinical response. This is the Wrst evaluation of NK and NKT cells as biomarkers of clinical response after rituximab therapy in rheumatic diseases.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-05-16T18:10:04Z No. of bitstreams: 1 __www.springerlink.com_c...k2464146086630h7_fulltext.pdf: 174093 bytes, checksum: f7383fe55843dc019ca73a11241bc925 (MD5)Made available in DSpace on 2012-05-16T18:10:04Z (GMT). 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| dc.title.pt_BR.fl_str_mv |
NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis |
| dc.title.alternative.pt_BR.fl_str_mv |
Rheumatology International |
| title |
NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis |
| spellingShingle |
NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis Reis, Eliana A. G. Systemic lupus erythematosus Rheumatoid arthritis Natural killer cells Rituximab Leukocytes |
| title_short |
NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis |
| title_full |
NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis |
| title_fullStr |
NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis |
| title_full_unstemmed |
NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis |
| title_sort |
NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis |
| author |
Reis, Eliana A. G. |
| author_facet |
Reis, Eliana A. G. Athanazio, Daniel Abensur Lima, Isabella Silva, Natália Oliveira e Andrade, Jorge Clarencio Souza Jesus, Ronden Nunes de Barbosa, Lúcio Macedo Reis, Mitermayer Galvão dos Santiago, Mittermayer Barreto |
| author_role |
author |
| author2 |
Athanazio, Daniel Abensur Lima, Isabella Silva, Natália Oliveira e Andrade, Jorge Clarencio Souza Jesus, Ronden Nunes de Barbosa, Lúcio Macedo Reis, Mitermayer Galvão dos Santiago, Mittermayer Barreto |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Reis, Eliana A. G. Athanazio, Daniel Abensur Lima, Isabella Silva, Natália Oliveira e Andrade, Jorge Clarencio Souza Jesus, Ronden Nunes de Barbosa, Lúcio Macedo Reis, Mitermayer Galvão dos Santiago, Mittermayer Barreto Reis, Eliana A. G. Athanazio, Daniel Abensur Lima, Isabella Silva, Natália Oliveira e Andrade, Jorge Clarencio Souza Jesus, Ronden Nunes de Barbosa, Lúcio Macedo Reis, Mitermayer Galvão dos Santiago, Mittermayer Barreto |
| dc.subject.por.fl_str_mv |
Systemic lupus erythematosus Rheumatoid arthritis Natural killer cells Rituximab Leukocytes |
| topic |
Systemic lupus erythematosus Rheumatoid arthritis Natural killer cells Rituximab Leukocytes |
| description |
Acesso restrito: Texto completo. p. 469-475 |
| publishDate |
2009 |
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2009 |
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2012-05-16T18:10:04Z |
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info:eu-repo/semantics/publishedVersion |
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0172-8172 |
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v. 29, n. 4 |
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0172-8172 v. 29, n. 4 |
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http://www.repositorio.ufba.br/ri/handle/ri/5884 |
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