NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis

Detalhes bibliográficos
Autor(a) principal: Reis, Eliana A. G.
Data de Publicação: 2009
Outros Autores: Athanazio, Daniel Abensur, Lima, Isabella, Silva, Natália Oliveira e, Andrade, Jorge Clarencio Souza, Jesus, Ronden Nunes de, Barbosa, Lúcio Macedo, Reis, Mitermayer Galvão dos, Santiago, Mittermayer Barreto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5884
Resumo: Acesso restrito: Texto completo. p. 469-475
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spelling Reis, Eliana A. G.Athanazio, Daniel AbensurLima, IsabellaSilva, Natália Oliveira eAndrade, Jorge Clarencio SouzaJesus, Ronden Nunes deBarbosa, Lúcio MacedoReis, Mitermayer Galvão dosSantiago, Mittermayer BarretoReis, Eliana A. G.Athanazio, Daniel AbensurLima, IsabellaSilva, Natália Oliveira eAndrade, Jorge Clarencio SouzaJesus, Ronden Nunes deBarbosa, Lúcio MacedoReis, Mitermayer Galvão dosSantiago, Mittermayer Barreto2012-05-16T18:10:04Z20090172-8172http://www.repositorio.ufba.br/ri/handle/ri/5884v. 29, n. 4Acesso restrito: Texto completo. p. 469-475Biomarkers of clinical response to rituximab (RTX) therapy and early predictors of outcome are still under investigation. We report a Xow cytometric immunophenotyping analysis from peripheral blood leukocyte subpopulations of two patients with systemic lupus erythematosus (SLE) associated thrombocytopenia and one patient with rheumatoid arthritis (RA), before and after 6 weeks of treatment with RTX. Our results show a reduced population of CD19+ expressing cells (B cells) after RTX treatment in all three patients. Increased frequency of peripheral regulatory CD4+CD25high T cell subset and the CD3¡CD16¡CD56bright NK cell subset after RTX therapy were also observed in all patients, the latter being more pronounced in the SLE patient with sustained clinical response. In addition, an increased population of NKT cell subsets was observed in the patients with clinical response. This is the Wrst evaluation of NK and NKT cells as biomarkers of clinical response after rituximab therapy in rheumatic diseases.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-05-16T18:10:04Z No. of bitstreams: 1 __www.springerlink.com_c...k2464146086630h7_fulltext.pdf: 174093 bytes, checksum: f7383fe55843dc019ca73a11241bc925 (MD5)Made available in DSpace on 2012-05-16T18:10:04Z (GMT). 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dc.title.pt_BR.fl_str_mv NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
dc.title.alternative.pt_BR.fl_str_mv Rheumatology International
title NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
spellingShingle NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
Reis, Eliana A. G.
Systemic lupus erythematosus
Rheumatoid arthritis
Natural killer cells
Rituximab
Leukocytes
title_short NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
title_full NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
title_fullStr NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
title_full_unstemmed NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
title_sort NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
author Reis, Eliana A. G.
author_facet Reis, Eliana A. G.
Athanazio, Daniel Abensur
Lima, Isabella
Silva, Natália Oliveira e
Andrade, Jorge Clarencio Souza
Jesus, Ronden Nunes de
Barbosa, Lúcio Macedo
Reis, Mitermayer Galvão dos
Santiago, Mittermayer Barreto
author_role author
author2 Athanazio, Daniel Abensur
Lima, Isabella
Silva, Natália Oliveira e
Andrade, Jorge Clarencio Souza
Jesus, Ronden Nunes de
Barbosa, Lúcio Macedo
Reis, Mitermayer Galvão dos
Santiago, Mittermayer Barreto
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Reis, Eliana A. G.
Athanazio, Daniel Abensur
Lima, Isabella
Silva, Natália Oliveira e
Andrade, Jorge Clarencio Souza
Jesus, Ronden Nunes de
Barbosa, Lúcio Macedo
Reis, Mitermayer Galvão dos
Santiago, Mittermayer Barreto
Reis, Eliana A. G.
Athanazio, Daniel Abensur
Lima, Isabella
Silva, Natália Oliveira e
Andrade, Jorge Clarencio Souza
Jesus, Ronden Nunes de
Barbosa, Lúcio Macedo
Reis, Mitermayer Galvão dos
Santiago, Mittermayer Barreto
dc.subject.por.fl_str_mv Systemic lupus erythematosus
Rheumatoid arthritis
Natural killer cells
Rituximab
Leukocytes
topic Systemic lupus erythematosus
Rheumatoid arthritis
Natural killer cells
Rituximab
Leukocytes
description Acesso restrito: Texto completo. p. 469-475
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2012-05-16T18:10:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5884
dc.identifier.issn.none.fl_str_mv 0172-8172
dc.identifier.number.pt_BR.fl_str_mv v. 29, n. 4
identifier_str_mv 0172-8172
v. 29, n. 4
url http://www.repositorio.ufba.br/ri/handle/ri/5884
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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