Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid

Detalhes bibliográficos
Autor(a) principal: Costa, José Fernando Oliveira
Data de Publicação: 2008
Outros Autores: David, Juceni Pereira de Lima, David, Jorge Mauricio, Giulietti, Ana M., Queiroz, Luciano Paganucci de, Santos, Ricardo R., Soares, Milena Botelho Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/3437
Resumo: P. 11-15,Jan/Mar.
id UFBA-2_8866f7f60d5ee495c43aa8435445b697
oai_identifier_str oai:repositorio.ufba.br:ri/3437
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Costa, José Fernando OliveiraDavid, Juceni Pereira de LimaDavid, Jorge MauricioGiulietti, Ana M.Queiroz, Luciano Paganucci deSantos, Ricardo R.Soares, Milena Botelho PereiraCosta, José Fernando OliveiraDavid, Juceni Pereira de LimaDavid, Jorge MauricioGiulietti, Ana M.Queiroz, Luciano Paganucci deSantos, Ricardo R.Soares, Milena Botelho Pereira2011-10-21T12:06:39Z2011-10-21T12:06:39Z20080102-695Xhttp://www.repositorio.ufba.br/ri/handle/ri/3437v. 18, n. 1.P. 11-15,Jan/Mar.A família Boraginaceae é amplamente distribuída no Brasil e na região nordeste algumas espécies são usadas popularmente no tratamento de reumatismo, dores menstruais e dispepsias. Neste trabalho foram estudadas as espécies Cordia superba Cham. and C. rufescens A. DC., nativas da região semi-árida brasileira, objetivando investigar a atividade imunomoduladora. Seis extratos foram preparados a partir de partes aéreas das espécies. A citotoxicidade foi avaliada usando culturas de esplenócitos de camundongos BALB/c. A atividade imunomoduladora foi determinada por ensaios in vitro usando macrófagos e linfócitos murinos ativados. Macrófagos peritoneais obtidos de camundongos BALB/c foram estimulados com IFN-g and LPS na presença/ausência das amostras. A produção de NO foi medida indiretamente através do método de Griess. Três amostras inibiram a produção de NO em valores próximos a 50% (100 µg/mL). Os efeitos das amostras sobre os linfócitos foram avaliados cultivando esplenócitos de camundongos BALB/c em presença destas amostras e de concanavalina A. A proliferação foi determinada pela análise da incorporação de 3H-tritiada. Amostras de duas espécies apresentaram uma forte atividade inibidora sobre a proliferação de linfócitos e sobre a produção de IL-2. Dois extratos clorofórmicos (partes aéreas de C. rufescens) tiveram os menores valores de IC50 (7,6 and 11,0 µg/mL).Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2011-10-21T12:06:39Z No. of bitstreams: 1 a04v18n1.pdf: 222580 bytes, checksum: 3ab69bf263727133ceb5f0df04f50794 (MD5)Made available in DSpace on 2011-10-21T12:06:39Z (GMT). No. of bitstreams: 1 a04v18n1.pdf: 222580 bytes, checksum: 3ab69bf263727133ceb5f0df04f50794 (MD5) Previous issue date: 2008João PessoaCordiaBoraginaceaeatividade imunomoduladoraimmunomodulatory activityImmunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-aridRevista Brasileira de Farmacognosiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1906https://repositorio.ufba.br/bitstream/ri/3437/2/license.txte4de3be3d1359a37a52c5f537eba7f3cMD52ORIGINALa04v18n1.pdfa04v18n1.pdfapplication/pdf222580https://repositorio.ufba.br/bitstream/ri/3437/1/a04v18n1.pdf3ab69bf263727133ceb5f0df04f50794MD51TEXTa04v18n1.pdf.txta04v18n1.pdf.txtExtracted texttext/plain23700https://repositorio.ufba.br/bitstream/ri/3437/3/a04v18n1.pdf.txt9e989fe8f6a0a34dbd16ddbfcbe44f2cMD53ri/34372022-07-05 14:03:42.771oai:repositorio.ufba.br:ri/3437TGljZW5zZSBncmFudGVkIGJ5IEpVUkFOREkgREUgU09VWkEgU0lMVkEgKGpzc3VmYmFAaG90bWFpbC5jb20pIG9uIDIwMTEtMTAtMjFUMTI6MDY6MzlaIChHTVQpOgoKVGVybW8gZGUgTGljZW7Dp2EsIG7Do28gZXhjbHVzaXZvLCBwYXJhIG8gZGVww7NzaXRvIG5vIApyZXBvc2l0w7NyaW8gSW5zdGl0dWNpb25hbCBkYSBVRkJBCgogICAgUGVsbyBwcm9jZXNzbyBkZSBzdWJtaXNzw6NvIGRlIGRvY3VtZW50b3MsIG8gYXV0b3Igb3Ugc2V1CnJlcHJlc2VudGFudGUgbGVnYWwsIGFvIGFjZWl0YXIgZXNzZSB0ZXJtbyBkZSBsaWNlbsOnYSwgY29uY2VkZSBhbwpSZXBvc2l0w7NyaW8gSW5zdGl0dWNpb25hbCBkYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkYSBCYWhpYSBvIGRpcmVpdG8KZGUgbWFudGVyIHVtYSBjw7NwaWEgZW0gc2V1IHJlcG9zaXTDs3JpbyBjb20gYSBmaW5hbGlkYWRlLCBwcmltZWlyYSwgCmRlIHByZXNlcnZhw6fDo28uIEVzc2UgdGVybW8sIG7Do28gZXhjbHVzaXZvLCBtYW50w6ptIG9zIGRpcmVpdG9zIGRlIAphdXRvci9jb3B5cmlnaHQsIG1hcyBlbnRlbmRlIG8gZG9jdW1lbnRvIGNvbW8gcGFydGUgZG8gYWNlcnZvIGludGVsZWN0dWFsCiBkZXNzYSBVbml2ZXJzaWRhZGUuIAoKICAgIFBhcmEgb3MgZG9jdW1lbnRvcyBwdWJsaWNhZG9zIGNvbSByZXBhc3NlIGRlIGRpcmVpdG9zIGRlIApkaXN0cmlidWnDp8OjbywgZXNzZSB0ZXJtbyBkZSBsaWNlbsOnYSBlbnRlbmRlIHF1ZTogCgogICAgTWFudGVuZG8gb3PCoCBkaXJlaXRvcyBhdXRvcmFpcywgcmVwYXNzYWRvcyBhIHRlcmNlaXJvcywgZW0gY2FzbyAKZGUgcHVibGljYcOnw7VlcywgbyByZXBvc2l0w7NyaW8gcG9kZSByZXN0cmluZ2lyIG8gYWNlc3NvIGFvIHRleHRvIAppbnRlZ3JhbCwgbWFzIGxpYmVyYSBhcyBpbmZvcm1hw6fDtWVzIHNvYnJlIG8gZG9jdW1lbnRvIChNZXRhZGFkb3MgZGVzY3JpdGl2b3MpLgogRGVzdGEgZm9ybWEsIGF0ZW5kZW5kbyBhb3MgYW5zZWlvcyBkZXNzYSB1bml2ZXJzaWRhZGUgCmVtIG1hbnRlciBzdWEgcHJvZHXDp8OjbyBjaWVudMOtwq1maWNhIGNvbSBhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcGVsb3MgCmVkaXRvcmVzIGRlIHBlcmnDs2RpY29zLiAKCiAgICBQYXJhIGFzIHB1YmxpY2HDp8O1ZXMgZW0gaW5pY2lhdGl2YXMgcXVlIHNlZ3VlbSBhIHBvbMOtwq10aWNhIGRlIApBY2Vzc28gQWJlcnRvLCBvcyBkZXDDs3NpdG9zIGNvbXB1bHPDs3Jpb3MgbmVzc2UgcmVwb3NpdMOzcmlvIG1hbnTDqm0gCm9zIGRpcmVpdG9zIGF1dG9yYWlzLCBtYXMgbWFudMOqbSBvIGFjZXNzbyBpcnJlc3RyaXRvIGFvIG1ldGFkYWRvcyAKZSB0ZXh0byBjb21wbGV0by4gQXNzaW0sIGEgYWNlaXRhw6fDo28gZGVzc2UgdGVybW8gbsOjbyBuZWNlc3NpdGEgZGUgCmNvbnNlbnRpbWVudG8gcG9yIHBhcnRlIGRlIGF1dG9yZXMvZGV0ZW50b3JlcyBkb3MgZGlyZWl0b3MsIHBvciAKZXN0YXJlbSBlbSBpbmljaWF0aXZhcyBkZSBhY2Vzc28gYWJlcnRvLgoKICAgIEVtIGFtYm9zIG8gY2FzbywgZXNzZSB0ZXJtbyBkZSBsaWNlbsOnYSwgcG9kZSBzZXIgYWNlaXRvIHBlbG8gCmF1dG9yLCBkZXRlbnRvcmVzIGRlIGRpcmVpdG9zIGUvb3UgdGVyY2Vpcm9zIGFtcGFyYWRvcyBwZWxhIAp1bml2ZXJzaWRhZGUuIERldmlkbyBhb3MgZGlmZXJlbnRlcyBwcm9jZXNzb3MgcGVsbyBxdWFsIGEgc3VibWlzc8OjbyAKcG9kZSBvY29ycmVyLCBvIHJlcG9zaXTDs3JpbyBwZXJtaXRlIGEgYWNlaXRhw6fDo28gZGEgbGljZW7Dp2EgcG9yIAp0ZXJjZWlyb3MsIHNvbWVudGUgbm9zIGNhc29zIGRlIGRvY3VtZW50b3MgcHJvZHV6aWRvcyBwb3IgaW50ZWdyYW50ZXMgCmRhIFVGQkEgZSBzdWJtZXRpZG9zIHBvciBwZXNzb2FzIGFtcGFyYWRhcyBwb3IgZXN0YSBpbnN0aXR1acOnw6NvCg==Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:42Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid
dc.title.alternative.pt_BR.fl_str_mv Revista Brasileira de Farmacognosia
title Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid
spellingShingle Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid
Costa, José Fernando Oliveira
Cordia
Boraginaceae
atividade imunomoduladora
immunomodulatory activity
title_short Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid
title_full Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid
title_fullStr Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid
title_full_unstemmed Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid
title_sort Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid
author Costa, José Fernando Oliveira
author_facet Costa, José Fernando Oliveira
David, Juceni Pereira de Lima
David, Jorge Mauricio
Giulietti, Ana M.
Queiroz, Luciano Paganucci de
Santos, Ricardo R.
Soares, Milena Botelho Pereira
author_role author
author2 David, Juceni Pereira de Lima
David, Jorge Mauricio
Giulietti, Ana M.
Queiroz, Luciano Paganucci de
Santos, Ricardo R.
Soares, Milena Botelho Pereira
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, José Fernando Oliveira
David, Juceni Pereira de Lima
David, Jorge Mauricio
Giulietti, Ana M.
Queiroz, Luciano Paganucci de
Santos, Ricardo R.
Soares, Milena Botelho Pereira
Costa, José Fernando Oliveira
David, Juceni Pereira de Lima
David, Jorge Mauricio
Giulietti, Ana M.
Queiroz, Luciano Paganucci de
Santos, Ricardo R.
Soares, Milena Botelho Pereira
dc.subject.por.fl_str_mv Cordia
Boraginaceae
atividade imunomoduladora
immunomodulatory activity
topic Cordia
Boraginaceae
atividade imunomoduladora
immunomodulatory activity
description P. 11-15,Jan/Mar.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2011-10-21T12:06:39Z
dc.date.available.fl_str_mv 2011-10-21T12:06:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/3437
dc.identifier.issn.none.fl_str_mv 0102-695X
dc.identifier.number.pt_BR.fl_str_mv v. 18, n. 1.
identifier_str_mv 0102-695X
v. 18, n. 1.
url http://www.repositorio.ufba.br/ri/handle/ri/3437
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/3437/2/license.txt
https://repositorio.ufba.br/bitstream/ri/3437/1/a04v18n1.pdf
https://repositorio.ufba.br/bitstream/ri/3437/3/a04v18n1.pdf.txt
bitstream.checksum.fl_str_mv e4de3be3d1359a37a52c5f537eba7f3c
3ab69bf263727133ceb5f0df04f50794
9e989fe8f6a0a34dbd16ddbfcbe44f2c
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1801502418771378176

Registros relacionados