Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid

Detalhes bibliográficos
Autor(a) principal: Costa, José Fernando Oliveira
Data de Publicação: 2008
Outros Autores: David, Juceni Pereira de Lima, David, Jorge Mauricio, Giulietti, Ana M., Queiroz, Luciano Paganucci de, Santos, Ricardo R., Soares, Milena Botelho Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/3437
Resumo: P. 11-15,Jan/Mar.
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spelling Costa, José Fernando OliveiraDavid, Juceni Pereira de LimaDavid, Jorge MauricioGiulietti, Ana M.Queiroz, Luciano Paganucci deSantos, Ricardo R.Soares, Milena Botelho PereiraCosta, José Fernando OliveiraDavid, Juceni Pereira de LimaDavid, Jorge MauricioGiulietti, Ana M.Queiroz, Luciano Paganucci deSantos, Ricardo R.Soares, Milena Botelho Pereira2011-10-21T12:06:39Z2011-10-21T12:06:39Z20080102-695Xhttp://www.repositorio.ufba.br/ri/handle/ri/3437v. 18, n. 1.P. 11-15,Jan/Mar.A família Boraginaceae é amplamente distribuída no Brasil e na região nordeste algumas espécies são usadas popularmente no tratamento de reumatismo, dores menstruais e dispepsias. Neste trabalho foram estudadas as espécies Cordia superba Cham. and C. rufescens A. DC., nativas da região semi-árida brasileira, objetivando investigar a atividade imunomoduladora. Seis extratos foram preparados a partir de partes aéreas das espécies. A citotoxicidade foi avaliada usando culturas de esplenócitos de camundongos BALB/c. A atividade imunomoduladora foi determinada por ensaios in vitro usando macrófagos e linfócitos murinos ativados. Macrófagos peritoneais obtidos de camundongos BALB/c foram estimulados com IFN-g and LPS na presença/ausência das amostras. A produção de NO foi medida indiretamente através do método de Griess. Três amostras inibiram a produção de NO em valores próximos a 50% (100 µg/mL). Os efeitos das amostras sobre os linfócitos foram avaliados cultivando esplenócitos de camundongos BALB/c em presença destas amostras e de concanavalina A. A proliferação foi determinada pela análise da incorporação de 3H-tritiada. Amostras de duas espécies apresentaram uma forte atividade inibidora sobre a proliferação de linfócitos e sobre a produção de IL-2. Dois extratos clorofórmicos (partes aéreas de C. rufescens) tiveram os menores valores de IC50 (7,6 and 11,0 µg/mL).Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2011-10-21T12:06:39Z No. of bitstreams: 1 a04v18n1.pdf: 222580 bytes, checksum: 3ab69bf263727133ceb5f0df04f50794 (MD5)Made available in DSpace on 2011-10-21T12:06:39Z (GMT). No. of bitstreams: 1 a04v18n1.pdf: 222580 bytes, checksum: 3ab69bf263727133ceb5f0df04f50794 (MD5) Previous issue date: 2008João PessoaCordiaBoraginaceaeatividade imunomoduladoraimmunomodulatory activityImmunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-aridRevista Brasileira de Farmacognosiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1906https://repositorio.ufba.br/bitstream/ri/3437/2/license.txte4de3be3d1359a37a52c5f537eba7f3cMD52ORIGINALa04v18n1.pdfa04v18n1.pdfapplication/pdf222580https://repositorio.ufba.br/bitstream/ri/3437/1/a04v18n1.pdf3ab69bf263727133ceb5f0df04f50794MD51TEXTa04v18n1.pdf.txta04v18n1.pdf.txtExtracted texttext/plain23700https://repositorio.ufba.br/bitstream/ri/3437/3/a04v18n1.pdf.txt9e989fe8f6a0a34dbd16ddbfcbe44f2cMD53ri/34372022-07-05 14:03:42.771oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:42Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid
dc.title.alternative.pt_BR.fl_str_mv Revista Brasileira de Farmacognosia
title Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid
spellingShingle Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid
Costa, José Fernando Oliveira
Cordia
Boraginaceae
atividade imunomoduladora
immunomodulatory activity
title_short Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid
title_full Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid
title_fullStr Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid
title_full_unstemmed Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid
title_sort Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid
author Costa, José Fernando Oliveira
author_facet Costa, José Fernando Oliveira
David, Juceni Pereira de Lima
David, Jorge Mauricio
Giulietti, Ana M.
Queiroz, Luciano Paganucci de
Santos, Ricardo R.
Soares, Milena Botelho Pereira
author_role author
author2 David, Juceni Pereira de Lima
David, Jorge Mauricio
Giulietti, Ana M.
Queiroz, Luciano Paganucci de
Santos, Ricardo R.
Soares, Milena Botelho Pereira
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, José Fernando Oliveira
David, Juceni Pereira de Lima
David, Jorge Mauricio
Giulietti, Ana M.
Queiroz, Luciano Paganucci de
Santos, Ricardo R.
Soares, Milena Botelho Pereira
Costa, José Fernando Oliveira
David, Juceni Pereira de Lima
David, Jorge Mauricio
Giulietti, Ana M.
Queiroz, Luciano Paganucci de
Santos, Ricardo R.
Soares, Milena Botelho Pereira
dc.subject.por.fl_str_mv Cordia
Boraginaceae
atividade imunomoduladora
immunomodulatory activity
topic Cordia
Boraginaceae
atividade imunomoduladora
immunomodulatory activity
description P. 11-15,Jan/Mar.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2011-10-21T12:06:39Z
dc.date.available.fl_str_mv 2011-10-21T12:06:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.issn.none.fl_str_mv 0102-695X
dc.identifier.number.pt_BR.fl_str_mv v. 18, n. 1.
identifier_str_mv 0102-695X
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dc.language.iso.fl_str_mv eng
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