Cytokine profile and pathology in human leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Jesus, A. Ribeiro de
Data de Publicação: 1998
Outros Autores: Almeida, Roque Pacheco de, Lessa, Hélio Andrade, Bacellar, Maria Olívia Amado Ramos, Carvalho Filho, Edgar Marcelino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7036
Resumo: p.143-148
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spelling Jesus, A. Ribeiro deAlmeida, Roque Pacheco deLessa, Hélio AndradeBacellar, Maria Olívia Amado RamosCarvalho Filho, Edgar Marcelino deJesus, A. Ribeiro deAlmeida, Roque Pacheco deLessa, Hélio AndradeBacellar, Maria Olívia Amado RamosCarvalho Filho, Edgar Marcelino de2012-10-23T18:40:11Z2012-10-23T18:40:11Z19981414-431Xhttp://www.repositorio.ufba.br/ri/handle/ri/7036v. 31, n. 1p.143-148The clinical spectrum of leishmaniasis and control of the infection are influenced by the parasite-host relationship. The role of cellular immune responses of the Th1 type in the protection against disease in experimental and human leishmaniasis is well established. In humans, production of IFN- is associated with the control of infection in children infected by Leishmania chagasi. In visceral leishmaniasis, an impairment in IFN- production and high IL-4 and IL-10 levels (Th2 cytokines) are observed in antigen-stimulated peripheral blood mononuclear cells (PBMC). Moreover, IL-12 restores IFN- production and enhances the cytotoxic response. IL-10 is the cytokine involved in down-regulation of IFN- production, since anti-IL-10 monoclonal antibody (mAb) restores in vitro IFN- production and lymphoproliferative responses, and IL-10 abrogates the effect of IL-12. In cutaneous and mucosal leishmaniasis, high levels of IFN- are found in L. amazonensis-stimulated PBMC. However, low or absent IFN- levels were observed in antigen-stimulated PBMC from 50% of subjects with less than 60 days of disease (24 ± 26 pg/ml). This response was restored by IL-12 (308 ± 342 pg/ml) and anti-IL-10 mAb (380 ± 245 pg/ml) (P<0.05). Later during the disease, high levels of IFN- and TNF- are produced both in cutaneous and mucosal leishmaniasis. After treatment there is a decrease in TNF- levels (366 ± 224 pg/ml before treatment vs 142 ± 107 pg/ml after treatment, P = 0.02). Although production of IFN- and TNF- might be involved in the control of parasite multiplication in the early phases of Leishmania infection, these cytokines might also be involved in the tissue damage seen in tegumentary leishmaniasis.Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-10-23T18:40:11Z No. of bitstreams: 1 Ribeiro-de-Jesus, A.pdf: 226801 bytes, checksum: 7a9bc9775d64eb82a1d00e52369e01f5 (MD5)Made available in DSpace on 2012-10-23T18:40:11Z (GMT). No. of bitstreams: 1 Ribeiro-de-Jesus, A.pdf: 226801 bytes, checksum: 7a9bc9775d64eb82a1d00e52369e01f5 (MD5) Previous issue date: 1998-01Ribeirão PretoBrazilian Journal of Medical and Biological Researchhttp://dx.doi.org/10.1590/S0100-879X1998000100020reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmaniasisHuman leishmaniasisCytokinesPathologyImmunological responsesCytokine profile and pathology in human leishmaniasisBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1809https://repositorio.ufba.br/bitstream/ri/7036/2/license.txt8bb3e3eb871f5854a9ec419f68651b60MD52ORIGINALRibeiro-de-Jesus, A.pdfRibeiro-de-Jesus, A.pdfapplication/pdf226801https://repositorio.ufba.br/bitstream/ri/7036/1/Ribeiro-de-Jesus%2c%20A.pdf7a9bc9775d64eb82a1d00e52369e01f5MD51TEXTRibeiro-de-Jesus, A.pdf.txtRibeiro-de-Jesus, A.pdf.txtExtracted texttext/plain24241https://repositorio.ufba.br/bitstream/ri/7036/3/Ribeiro-de-Jesus%2c%20A.pdf.txteaa80eeee49bd851a7a0e9a25cbc7543MD53ri/70362022-09-23 11:34:50.594oai:repositorio.ufba.br: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ório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-09-23T14:34:50Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Cytokine profile and pathology in human leishmaniasis
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Medical and Biological Research
title Cytokine profile and pathology in human leishmaniasis
spellingShingle Cytokine profile and pathology in human leishmaniasis
Jesus, A. Ribeiro de
Leishmaniasis
Human leishmaniasis
Cytokines
Pathology
Immunological responses
title_short Cytokine profile and pathology in human leishmaniasis
title_full Cytokine profile and pathology in human leishmaniasis
title_fullStr Cytokine profile and pathology in human leishmaniasis
title_full_unstemmed Cytokine profile and pathology in human leishmaniasis
title_sort Cytokine profile and pathology in human leishmaniasis
author Jesus, A. Ribeiro de
author_facet Jesus, A. Ribeiro de
Almeida, Roque Pacheco de
Lessa, Hélio Andrade
Bacellar, Maria Olívia Amado Ramos
Carvalho Filho, Edgar Marcelino de
author_role author
author2 Almeida, Roque Pacheco de
Lessa, Hélio Andrade
Bacellar, Maria Olívia Amado Ramos
Carvalho Filho, Edgar Marcelino de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Jesus, A. Ribeiro de
Almeida, Roque Pacheco de
Lessa, Hélio Andrade
Bacellar, Maria Olívia Amado Ramos
Carvalho Filho, Edgar Marcelino de
Jesus, A. Ribeiro de
Almeida, Roque Pacheco de
Lessa, Hélio Andrade
Bacellar, Maria Olívia Amado Ramos
Carvalho Filho, Edgar Marcelino de
dc.subject.por.fl_str_mv Leishmaniasis
Human leishmaniasis
Cytokines
Pathology
Immunological responses
topic Leishmaniasis
Human leishmaniasis
Cytokines
Pathology
Immunological responses
description p.143-148
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2012-10-23T18:40:11Z
dc.date.available.fl_str_mv 2012-10-23T18:40:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7036
dc.identifier.issn.none.fl_str_mv 1414-431X
dc.identifier.number.pt_BR.fl_str_mv v. 31, n. 1
identifier_str_mv 1414-431X
v. 31, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/7036
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Brazilian Journal of Medical and Biological Research
publisher.none.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0100-879X1998000100020
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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