Human-Leishmaniasis@cytokines.bahia.br
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1998 |
| Outros Autores: | , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/3145 |
Resumo: | p. 149-155 |
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Carvalho Filho, Edgar Marcelino deBarral, Aldina Maria PradoBarral-Netto, ManoelBrodskyn, Claudia IdaCarvalho Filho, Edgar Marcelino deBarral, Aldina Maria PradoBarral-Netto, ManoelBrodskyn, Claudia Ida2011-10-06T13:43:59Z2011-10-06T13:43:59Z19981678-4510http://www.repositorio.ufba.br/ri/handle/ri/314531(1)p. 149-155The cell-mediated immune response is critical in the resistance to and recovery from leishmaniasis. Cytokines are central elements in mounting an immune response and have received a great deal of attention in both human and experimental leishmaniasis. IFN-g is responsible for macrophage activation leading to leishmanicidal mechanisms. Understanding the balance of cytokines that lead to enhanced production of or synergize with IFN-g, and those cytokines that counterbalance its effects is fundamental for developing rational immunotherapeutic or immunoprophylactic approaches to leishmaniasis. Here we focus on the cytokine balance in human leishmaniasis, particularly IL-10 as an IFN-g opposing cytokine, and IL-12 as an IFN-g inducer. The effects of these cytokines were evaluated in terms of several parameters of the human immune response. IL-10 reduced lymphocyte proliferation, IFN-g production and cytotoxic activity of responsive human peripheral blood mononuclear cells. Neutralization of IL-10 led to partial restoration of lymphoproliferation, IFN-g production and cytotoxic activity in unresponsive visceral leishmaniasis patients. IL-12 also restored the responses of peripheral blood mononuclear cells from visceral leishmaniasis patients. The responses obtained with IL-12 are higher than those obtained with anti-IL-10, even when anti-IL-10 is combined with anti-IL-4.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2011-10-06T13:43:59Z No. of bitstreams: 1 3051c.pdf: 298111 bytes, checksum: 0a9eee5a6728b4cde44d807f53c00203 (MD5)Made available in DSpace on 2011-10-06T13:43:59Z (GMT). No. of bitstreams: 1 3051c.pdf: 298111 bytes, checksum: 0a9eee5a6728b4cde44d807f53c00203 (MD5) Previous issue date: 1998CytokinesHuman leishmaniasisImmunoregulationIL-12IL-10Human-Leishmaniasis@cytokines.bahia.brBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINAL3051c.pdf3051c.pdfapplication/pdf298111https://repositorio.ufba.br/bitstream/ri/3145/1/3051c.pdf0a9eee5a6728b4cde44d807f53c00203MD51LICENSElicense.txtlicense.txttext/plain1918https://repositorio.ufba.br/bitstream/ri/3145/2/license.txtf6e5bd45f8bb56224f8c8e6df9351b0eMD52TEXT3051c.pdf.txt3051c.pdf.txtExtracted texttext/plain30370https://repositorio.ufba.br/bitstream/ri/3145/3/3051c.pdf.txtf9b527aafb2bb46590d888e8f422cbdeMD53ri/31452022-07-05 14:03:20.318oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:20Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Human-Leishmaniasis@cytokines.bahia.br |
| dc.title.alternative.pt_BR.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
| title |
Human-Leishmaniasis@cytokines.bahia.br |
| spellingShingle |
Human-Leishmaniasis@cytokines.bahia.br Carvalho Filho, Edgar Marcelino de Cytokines Human leishmaniasis Immunoregulation IL-12 IL-10 |
| title_short |
Human-Leishmaniasis@cytokines.bahia.br |
| title_full |
Human-Leishmaniasis@cytokines.bahia.br |
| title_fullStr |
Human-Leishmaniasis@cytokines.bahia.br |
| title_full_unstemmed |
Human-Leishmaniasis@cytokines.bahia.br |
| title_sort |
Human-Leishmaniasis@cytokines.bahia.br |
| author |
Carvalho Filho, Edgar Marcelino de |
| author_facet |
Carvalho Filho, Edgar Marcelino de Barral, Aldina Maria Prado Barral-Netto, Manoel Brodskyn, Claudia Ida |
| author_role |
author |
| author2 |
Barral, Aldina Maria Prado Barral-Netto, Manoel Brodskyn, Claudia Ida |
| author2_role |
author author author |
| dc.contributor.author.fl_str_mv |
Carvalho Filho, Edgar Marcelino de Barral, Aldina Maria Prado Barral-Netto, Manoel Brodskyn, Claudia Ida Carvalho Filho, Edgar Marcelino de Barral, Aldina Maria Prado Barral-Netto, Manoel Brodskyn, Claudia Ida |
| dc.subject.por.fl_str_mv |
Cytokines Human leishmaniasis Immunoregulation IL-12 IL-10 |
| topic |
Cytokines Human leishmaniasis Immunoregulation IL-12 IL-10 |
| description |
p. 149-155 |
| publishDate |
1998 |
| dc.date.issued.fl_str_mv |
1998 |
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2011-10-06T13:43:59Z |
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2011-10-06T13:43:59Z |
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1678-4510 |
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31(1) |
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