A new approach to select solvents and operating conditions for supercritical antisolvent precipitation processes by using solubility parameter and group contribution methods

Detalhes bibliográficos
Autor(a) principal: Pereira, V. J.
Data de Publicação: 2013
Outros Autores: Matos, R. L., Cardoso, S. G., Soares, R. O., Santana, G. L., Costa, Glória Meyberg Nunes, Melo, Silvio Alexandre Beisl Vieira de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15217
Resumo: Texto completo: acesso restrito. p. 128–146
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spelling Pereira, V. J.Matos, R. L.Cardoso, S. G.Soares, R. O.Santana, G. L.Costa, Glória Meyberg NunesMelo, Silvio Alexandre Beisl Vieira dePereira, V. J.Matos, R. L.Cardoso, S. G.Soares, R. O.Santana, G. L.Costa, Glória Meyberg NunesMelo, Silvio Alexandre Beisl Vieira de2014-07-16T16:27:18Z20130896-8446http://repositorio.ufba.br/ri/handle/ri/15217v. 81Texto completo: acesso restrito. p. 128–146A new approach is proposed to select operating temperature and pressure for supercritical antisolvent particle precipitation based on solubility parameter calculated by group contribution methods and using only the critical properties of the solvent. Solubility parameters are also used to choose the most suitable organic solvent for a given application. Supercritical antisolvent precipitation operating conditions of 36 systems are investigated including 8 organic solvents (methanol, ethanol, acetone, DMSO, DCM, chloroform, NMP and acetic acid) and 6 solid solutes (atenolol, tartaric acid, flunisolide, paracetamol, amoxicillin and cholesterol) in the temperature and pressure ranges of 25⿿85 °C and 50⿿250 bar. The results show a good agreement between the experimental and calculated data for these systems. Although particle precipitation depends on several parameters such as mass-transfer rates and hydrodynamics, the focus of this work is on the role of thermodynamics to indicate the preliminary conditions for a successful antisolvent precipitation process. Validation and results of this new approach suggest that it can be a useful tool for a qualitative and completely predictive evaluation of supercritical antisolvent particle precipitation in a cheaper way than carrying out experimental runs.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-05-20T11:29:51Z No. of bitstreams: 1 1-s2.0-S0896844613002192-main.pdf: 4293569 bytes, checksum: d7ecbf4917ed8d79a6c82bb0b666b0b9 (MD5)Approved for entry into archive by LIVIA FREITAS (livia.freitas@ufba.br) on 2014-07-16T16:27:18Z (GMT) No. of bitstreams: 1 1-s2.0-S0896844613002192-main.pdf: 4293569 bytes, checksum: d7ecbf4917ed8d79a6c82bb0b666b0b9 (MD5)Made available in DSpace on 2014-07-16T16:27:18Z (GMT). No. of bitstreams: 1 1-s2.0-S0896844613002192-main.pdf: 4293569 bytes, checksum: d7ecbf4917ed8d79a6c82bb0b666b0b9 (MD5) Previous issue date: 2013http://dx.doi.org/10.1016/j.supflu.2013.05.010reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASolventsPharmaceuticalsSolubilityPrecipitationSolubilizationA new approach to select solvents and operating conditions for supercritical antisolvent precipitation processes by using solubility parameter and group contribution methodsJournal of Supercritical FluidsArtigo de Periódicoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10000-01-01info:eu-repo/semantics/openAccessengORIGINAL1-s2.0-S0896844613002192-main.pdf1-s2.0-S0896844613002192-main.pdfapplication/pdf4293569https://repositorio.ufba.br/bitstream/ri/15217/1/1-s2.0-S0896844613002192-main.pdfd7ecbf4917ed8d79a6c82bb0b666b0b9MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15217/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXT1-s2.0-S0896844613002192-main.pdf.txt1-s2.0-S0896844613002192-main.pdf.txtExtracted texttext/plain49014https://repositorio.ufba.br/bitstream/ri/15217/3/1-s2.0-S0896844613002192-main.pdf.txt9cb44606ccc77e9eb0f71bb7bc844756MD53ri/152172022-08-26 11:47:07.488oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-26T14:47:07Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv A new approach to select solvents and operating conditions for supercritical antisolvent precipitation processes by using solubility parameter and group contribution methods
dc.title.alternative.pt_BR.fl_str_mv Journal of Supercritical Fluids
title A new approach to select solvents and operating conditions for supercritical antisolvent precipitation processes by using solubility parameter and group contribution methods
spellingShingle A new approach to select solvents and operating conditions for supercritical antisolvent precipitation processes by using solubility parameter and group contribution methods
Pereira, V. J.
Solvents
Pharmaceuticals
Solubility
Precipitation
Solubilization
title_short A new approach to select solvents and operating conditions for supercritical antisolvent precipitation processes by using solubility parameter and group contribution methods
title_full A new approach to select solvents and operating conditions for supercritical antisolvent precipitation processes by using solubility parameter and group contribution methods
title_fullStr A new approach to select solvents and operating conditions for supercritical antisolvent precipitation processes by using solubility parameter and group contribution methods
title_full_unstemmed A new approach to select solvents and operating conditions for supercritical antisolvent precipitation processes by using solubility parameter and group contribution methods
title_sort A new approach to select solvents and operating conditions for supercritical antisolvent precipitation processes by using solubility parameter and group contribution methods
author Pereira, V. J.
author_facet Pereira, V. J.
Matos, R. L.
Cardoso, S. G.
Soares, R. O.
Santana, G. L.
Costa, Glória Meyberg Nunes
Melo, Silvio Alexandre Beisl Vieira de
author_role author
author2 Matos, R. L.
Cardoso, S. G.
Soares, R. O.
Santana, G. L.
Costa, Glória Meyberg Nunes
Melo, Silvio Alexandre Beisl Vieira de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira, V. J.
Matos, R. L.
Cardoso, S. G.
Soares, R. O.
Santana, G. L.
Costa, Glória Meyberg Nunes
Melo, Silvio Alexandre Beisl Vieira de
Pereira, V. J.
Matos, R. L.
Cardoso, S. G.
Soares, R. O.
Santana, G. L.
Costa, Glória Meyberg Nunes
Melo, Silvio Alexandre Beisl Vieira de
dc.subject.por.fl_str_mv Solvents
Pharmaceuticals
Solubility
Precipitation
Solubilization
topic Solvents
Pharmaceuticals
Solubility
Precipitation
Solubilization
description Texto completo: acesso restrito. p. 128–146
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-07-16T16:27:18Z
dc.type.driver.fl_str_mv Artigo de Periódico
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15217
dc.identifier.issn.none.fl_str_mv 0896-8446
dc.identifier.number.pt_BR.fl_str_mv v. 81
identifier_str_mv 0896-8446
v. 81
url http://repositorio.ufba.br/ri/handle/ri/15217
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.supflu.2013.05.010
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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