Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations

Detalhes bibliográficos
Autor(a) principal: Chagas, Manoel Pinheiro
Data de Publicação: 2009
Outros Autores: Santos, Josué Carinhanha Caldas, Santos, Eduardo B. G. N., Oliveira, Tiago D., Korn, Mauro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5924
Resumo: p. 1646-1652
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spelling Chagas, Manoel PinheiroSantos, Josué Carinhanha CaldasSantos, Eduardo B. G. N.Oliveira, Tiago D.Korn, MauroChagas, Manoel PinheiroSantos, Josué Carinhanha CaldasSantos, Eduardo B. G. N.Oliveira, Tiago D.Korn, Mauro2012-05-18T15:06:03Z2012-05-18T15:06:03Z20090103-5053http://www.repositorio.ufba.br/ri/handle/ri/5924v. 20, n. 9p. 1646-1652A spectrophotometric flow analysis procedure to determine Captopril (CPT) and N-acetyl-L-cysteine (NAC) in pharmaceutical formulations was developed based on the reaction with iminoquinone radical produced from the N,N-dimethyl-p-phenilenediamene (DMPD) oxidation in acid medium. The reagents addition order was evaluated and analytical parameters were optimized. The linear concentrations ranges were 2.5-90 and 5.0-50 mg L-1 for CPT and NAC, respectively. Limits of detection (3σ) were calculated at 0.22 and 1.8 mg L-1 and the relative standard deviation (N = 10) were lower than 1.0 and 2.1% for CPT and NAC, respectively. The procedure was employed for CPT and NAC determination in diverse pharmaceutical formulations and by applying paired t-test the results were in agreement with those obtained by reference methods for 95% confidence level.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-05-18T15:06:03Z No. of bitstreams: 1 __www.scielo.br_pdf_jbchs_v20n9_12.pdf: 211865 bytes, checksum: 1a5c6c0de79940659536292ef52a9e00 (MD5)Made available in DSpace on 2012-05-18T15:06:03Z (GMT). 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dc.title.pt_BR.fl_str_mv Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations
dc.title.alternative.pt_BR.fl_str_mv Journal of the brazilian chemical society
title Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations
spellingShingle Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations
Chagas, Manoel Pinheiro
Iminoquinone radical reaction
Flow injection analysis
Determination of thiol drugs
Captopril
title_short Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations
title_full Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations
title_fullStr Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations
title_full_unstemmed Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations
title_sort Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations
author Chagas, Manoel Pinheiro
author_facet Chagas, Manoel Pinheiro
Santos, Josué Carinhanha Caldas
Santos, Eduardo B. G. N.
Oliveira, Tiago D.
Korn, Mauro
author_role author
author2 Santos, Josué Carinhanha Caldas
Santos, Eduardo B. G. N.
Oliveira, Tiago D.
Korn, Mauro
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Chagas, Manoel Pinheiro
Santos, Josué Carinhanha Caldas
Santos, Eduardo B. G. N.
Oliveira, Tiago D.
Korn, Mauro
Chagas, Manoel Pinheiro
Santos, Josué Carinhanha Caldas
Santos, Eduardo B. G. N.
Oliveira, Tiago D.
Korn, Mauro
dc.subject.por.fl_str_mv Iminoquinone radical reaction
Flow injection analysis
Determination of thiol drugs
Captopril
topic Iminoquinone radical reaction
Flow injection analysis
Determination of thiol drugs
Captopril
description p. 1646-1652
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2012-05-18T15:06:03Z
dc.date.available.fl_str_mv 2012-05-18T15:06:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5924
dc.identifier.issn.none.fl_str_mv 0103-5053
dc.identifier.number.pt_BR.fl_str_mv v. 20, n. 9
identifier_str_mv 0103-5053
v. 20, n. 9
url http://www.repositorio.ufba.br/ri/handle/ri/5924
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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