Potentiometric determination of captopril in pharmaceutical formulations

Detalhes bibliográficos
Autor(a) principal: Ribeiro,P. R. da S.
Data de Publicação: 2003
Outros Autores: Santini,A. O., Pezza,H. R., Pezza,L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Eclética Química
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702003000100005
Resumo: A simple, precise, rapid and low-cost potentiometric method for captopril determination in pure form and in pharmaceutical preparations is proposed. Captopril present in tablets containing known quantity of drug was potentiometrically titrated in aqueous solution with NaOH using a glass pH electrode, coupled to an autotitrator. No interferences were observed in the presence of common components of the tablets as lactose, microcrystalline cellulose, croscarmellose sodium, starch and magnesium stearate. The analytical results obtained by applying the proposed method compared very favorably with those obtained by the United States Pharmacopoeia Standard procedure. Recovery of captopril from various tablet dosage formulations range from 98.0 to 102.0%.
id UNESP-29_89ef6fb0b039b509fb830a38b62c8f8f
oai_identifier_str oai:scielo:S0100-46702003000100005
network_acronym_str UNESP-29
network_name_str Eclética Química
repository_id_str
spelling Potentiometric determination of captopril in pharmaceutical formulationspotentiometric determinationcaptoprilpharmaceutical formulationsA simple, precise, rapid and low-cost potentiometric method for captopril determination in pure form and in pharmaceutical preparations is proposed. Captopril present in tablets containing known quantity of drug was potentiometrically titrated in aqueous solution with NaOH using a glass pH electrode, coupled to an autotitrator. No interferences were observed in the presence of common components of the tablets as lactose, microcrystalline cellulose, croscarmellose sodium, starch and magnesium stearate. The analytical results obtained by applying the proposed method compared very favorably with those obtained by the United States Pharmacopoeia Standard procedure. Recovery of captopril from various tablet dosage formulations range from 98.0 to 102.0%.Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP2003-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702003000100005Eclética Química v.28 n.1 2003reponame:Eclética Químicainstname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)instacron:UNESP10.1590/S0100-46702003000100005info:eu-repo/semantics/openAccessRibeiro,P. R. da S.Santini,A. O.Pezza,H. R.Pezza,L.eng2003-12-08T00:00:00Zoai:scielo:S0100-46702003000100005Revistahttp://revista.iq.unesp.br/ojs/index.php/ecletica/PUBhttps://revista.iq.unesp.br/ojs/index.php/ecletica/oaiecletica@ctrlk.com.br||ecletica@iq.unesp.br1678-46181678-4618opendoar:2003-12-08T00:00Eclética Química - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)false
dc.title.none.fl_str_mv Potentiometric determination of captopril in pharmaceutical formulations
title Potentiometric determination of captopril in pharmaceutical formulations
spellingShingle Potentiometric determination of captopril in pharmaceutical formulations
Ribeiro,P. R. da S.
potentiometric determination
captopril
pharmaceutical formulations
title_short Potentiometric determination of captopril in pharmaceutical formulations
title_full Potentiometric determination of captopril in pharmaceutical formulations
title_fullStr Potentiometric determination of captopril in pharmaceutical formulations
title_full_unstemmed Potentiometric determination of captopril in pharmaceutical formulations
title_sort Potentiometric determination of captopril in pharmaceutical formulations
author Ribeiro,P. R. da S.
author_facet Ribeiro,P. R. da S.
Santini,A. O.
Pezza,H. R.
Pezza,L.
author_role author
author2 Santini,A. O.
Pezza,H. R.
Pezza,L.
author2_role author
author
author
dc.contributor.author.fl_str_mv Ribeiro,P. R. da S.
Santini,A. O.
Pezza,H. R.
Pezza,L.
dc.subject.por.fl_str_mv potentiometric determination
captopril
pharmaceutical formulations
topic potentiometric determination
captopril
pharmaceutical formulations
description A simple, precise, rapid and low-cost potentiometric method for captopril determination in pure form and in pharmaceutical preparations is proposed. Captopril present in tablets containing known quantity of drug was potentiometrically titrated in aqueous solution with NaOH using a glass pH electrode, coupled to an autotitrator. No interferences were observed in the presence of common components of the tablets as lactose, microcrystalline cellulose, croscarmellose sodium, starch and magnesium stearate. The analytical results obtained by applying the proposed method compared very favorably with those obtained by the United States Pharmacopoeia Standard procedure. Recovery of captopril from various tablet dosage formulations range from 98.0 to 102.0%.
publishDate 2003
dc.date.none.fl_str_mv 2003-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702003000100005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702003000100005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-46702003000100005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP
publisher.none.fl_str_mv Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP
dc.source.none.fl_str_mv Eclética Química v.28 n.1 2003
reponame:Eclética Química
instname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Eclética Química
collection Eclética Química
repository.name.fl_str_mv Eclética Química - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
repository.mail.fl_str_mv ecletica@ctrlk.com.br||ecletica@iq.unesp.br
_version_ 1754734617628246016

Registros relacionados