DNA vaccines induce partial protection against Leishmania mexicana

Detalhes bibliográficos
Autor(a) principal: Jesus, Ramirez Sierra Maria
Data de Publicação: 2003
Outros Autores: Dumonteil, Eric, Javier, Escobedo Ortegon, del Rosario, Garcı́a Miss Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14296
Resumo: Texto completo: acesso restrito. p. 2161–2168
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spelling Jesus, Ramirez Sierra MariaDumonteil, EricJavier, Escobedo Ortegondel Rosario, Garcı́a Miss MariaJesus, Ramirez Sierra MariaDumonteil, EricJavier, Escobedo Ortegondel Rosario, Garcı́a Miss Maria2014-01-08T13:37:08Z20030264-410Xhttp://repositorio.ufba.br/ri/handle/ri/14296v. 21 n. 17-18Texto completo: acesso restrito. p. 2161–2168As part of an ongoing effort to develop a vaccine against Leishmania mexicana, we tested DNA vaccines encoding L. mexicana GP63, CPb, and LACK, and L. amazonensis GP46, to evaluate this strategy and define the best antigen candidates. Immune responses and vaccine efficacy were evaluated in BALB/c mice immunized with plasmid DNA encoding the different antigens. All four DNA vaccines induced Leishmania-specific humoral and lympho-proliferative immune responses. However, only mice immunized with VR1012-GP46, VR1012-GP63 and VR1012-CPb were partially protected against infection, as evidenced by reduced lesion size and parasite burden. Interestingly, immunization of mice with a mixture of these three plasmids further increased protection. Thus, plasmids encoding CPb, GP63 and GP46 represent good candidates for further development of DNA vaccines against L. mexicana.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-01-06T12:23:41Z No. of bitstreams: 1 Ramirez Sierra Maria Jesus.pdf: 140934 bytes, checksum: 95796a7d23d992470fc13a980de0f391 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-01-08T13:37:08Z (GMT) No. of bitstreams: 1 Ramirez Sierra Maria Jesus.pdf: 140934 bytes, checksum: 95796a7d23d992470fc13a980de0f391 (MD5)Made available in DSpace on 2014-01-08T13:37:08Z (GMT). No. of bitstreams: 1 Ramirez Sierra Maria Jesus.pdf: 140934 bytes, checksum: 95796a7d23d992470fc13a980de0f391 (MD5) Previous issue date: 2003http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/S0264-410X(02)00769-7reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmania mexicanaDNA vaccinesPartial protectionDNA vaccines induce partial protection against Leishmania mexicanaVaccineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALRamirez Sierra Maria Jesus.pdfRamirez Sierra Maria Jesus.pdfapplication/pdf140934https://repositorio.ufba.br/bitstream/ri/14296/1/Ramirez%20Sierra%20Maria%20Jesus.pdf95796a7d23d992470fc13a980de0f391MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14296/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTRamirez Sierra Maria Jesus.pdf.txtRamirez Sierra Maria Jesus.pdf.txtExtracted texttext/plain32441https://repositorio.ufba.br/bitstream/ri/14296/3/Ramirez%20Sierra%20Maria%20Jesus.pdf.txt7673c19c2a552f42520ff04b1f8990f6MD53ri/142962022-07-05 14:02:48.692oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:48Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv DNA vaccines induce partial protection against Leishmania mexicana
dc.title.alternative.pt_BR.fl_str_mv Vaccine
title DNA vaccines induce partial protection against Leishmania mexicana
spellingShingle DNA vaccines induce partial protection against Leishmania mexicana
Jesus, Ramirez Sierra Maria
Leishmania mexicana
DNA vaccines
Partial protection
title_short DNA vaccines induce partial protection against Leishmania mexicana
title_full DNA vaccines induce partial protection against Leishmania mexicana
title_fullStr DNA vaccines induce partial protection against Leishmania mexicana
title_full_unstemmed DNA vaccines induce partial protection against Leishmania mexicana
title_sort DNA vaccines induce partial protection against Leishmania mexicana
author Jesus, Ramirez Sierra Maria
author_facet Jesus, Ramirez Sierra Maria
Dumonteil, Eric
Javier, Escobedo Ortegon
del Rosario, Garcı́a Miss Maria
author_role author
author2 Dumonteil, Eric
Javier, Escobedo Ortegon
del Rosario, Garcı́a Miss Maria
author2_role author
author
author
dc.contributor.author.fl_str_mv Jesus, Ramirez Sierra Maria
Dumonteil, Eric
Javier, Escobedo Ortegon
del Rosario, Garcı́a Miss Maria
Jesus, Ramirez Sierra Maria
Dumonteil, Eric
Javier, Escobedo Ortegon
del Rosario, Garcı́a Miss Maria
dc.subject.por.fl_str_mv Leishmania mexicana
DNA vaccines
Partial protection
topic Leishmania mexicana
DNA vaccines
Partial protection
description Texto completo: acesso restrito. p. 2161–2168
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2014-01-08T13:37:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14296
dc.identifier.issn.none.fl_str_mv 0264-410X
dc.identifier.number.pt_BR.fl_str_mv v. 21 n. 17-18
identifier_str_mv 0264-410X
v. 21 n. 17-18
url http://repositorio.ufba.br/ri/handle/ri/14296
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/S0264-410X(02)00769-7
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instname_str Universidade Federal da Bahia (UFBA)
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institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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