Acute fluoxetine administration differentially affects brain C-Fos expression in fasted and refed rats

Detalhes bibliográficos
Autor(a) principal: Fraga, I. C.
Data de Publicação: 2005
Outros Autores: Fregoneze, J. B., Carvalho, F. L. Q., Dantas, K. B., Azevedo, C. S., Pinho, Cristina Bacellar de, Silva, E. de Castro e
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6675
Resumo: Trabalho completo: acesso restrito, p. 327–334
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spelling Fraga, I. C.Fregoneze, J. B.Carvalho, F. L. Q.Dantas, K. B.Azevedo, C. S.Pinho, Cristina Bacellar deSilva, E. de Castro eFraga, I. C.Fregoneze, J. B.Carvalho, F. L. Q.Dantas, K. B.Azevedo, C. S.Pinho, Cristina Bacellar deSilva, E. de Castro e2012-08-31T19:26:35Z20050306-4522http://www.repositorio.ufba.br/ri/handle/ri/6675v. 134, n. 1Trabalho completo: acesso restrito, p. 327–334In the present study we investigated the effect of acute fluoxetine administration on the expression of c-Fos in the rat brain under two different metabolic conditions: fed and fasting states. Wistar male rats, weighing 220±30g, received i.p. injections of saline solution or fluoxetine (10mg/kg), and were killed 2 h later. The brains were removed after transcardiac perfusion with phosphate-buffered saline followed by paraformaldehyde, and were then processed for immunohistochemistry. Fos-like immunoreactivity was quantified by a computerized system. Fasted animals faced an 18-h suppression of food intake, while fed groups were submitted to an initial 14-h period of fast followed by a 4-h period in which food was freely available. Both in fasting and fed states, fluoxetine-treated animals presented a significant increase in c-Fos expression in hypothalamic areas, limbic structures, circumventricular areas, and in mesencephalic and rhomboencephalic regions, as compared with saline-treated controls. The quantitative comparison of data obtained from fasted and fed animals showed that fasted rats treated with fluoxetine presented a higher c-Fos expression in the ventromedial hypothalamus and the paraventricular nuclei compared with the fed group, while in fluoxetine-treated fed rats c-Fos expression was higher in the arcuate nuclei, medial amygdala, locus coeruleus and dorsal raphe nuclei, as compared with fasted, fluoxetine-treated animals. These data indicate that the metabolic condition of the animals significantly modifies fluoxetine-induced brain c-Fos expression, suggesting that visceral and behavioral fluoxetine effects may be influenced by the metabolic state of the individual.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-08-31T19:26:35Z No. of bitstreams: 1 (186).pdf: 604018 bytes, checksum: a1cd84b6dc748a2da0d60bda6860cf3a (MD5)Made available in DSpace on 2012-08-31T19:26:35Z (GMT). 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dc.title.pt_BR.fl_str_mv Acute fluoxetine administration differentially affects brain C-Fos expression in fasted and refed rats
dc.title.alternative.pt_BR.fl_str_mv Neuroscience
title Acute fluoxetine administration differentially affects brain C-Fos expression in fasted and refed rats
spellingShingle Acute fluoxetine administration differentially affects brain C-Fos expression in fasted and refed rats
Fraga, I. C.
serotonin reuptake inhibitors
Fos-IR
serotonin
fed state
fasting state
title_short Acute fluoxetine administration differentially affects brain C-Fos expression in fasted and refed rats
title_full Acute fluoxetine administration differentially affects brain C-Fos expression in fasted and refed rats
title_fullStr Acute fluoxetine administration differentially affects brain C-Fos expression in fasted and refed rats
title_full_unstemmed Acute fluoxetine administration differentially affects brain C-Fos expression in fasted and refed rats
title_sort Acute fluoxetine administration differentially affects brain C-Fos expression in fasted and refed rats
author Fraga, I. C.
author_facet Fraga, I. C.
Fregoneze, J. B.
Carvalho, F. L. Q.
Dantas, K. B.
Azevedo, C. S.
Pinho, Cristina Bacellar de
Silva, E. de Castro e
author_role author
author2 Fregoneze, J. B.
Carvalho, F. L. Q.
Dantas, K. B.
Azevedo, C. S.
Pinho, Cristina Bacellar de
Silva, E. de Castro e
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fraga, I. C.
Fregoneze, J. B.
Carvalho, F. L. Q.
Dantas, K. B.
Azevedo, C. S.
Pinho, Cristina Bacellar de
Silva, E. de Castro e
Fraga, I. C.
Fregoneze, J. B.
Carvalho, F. L. Q.
Dantas, K. B.
Azevedo, C. S.
Pinho, Cristina Bacellar de
Silva, E. de Castro e
dc.subject.por.fl_str_mv serotonin reuptake inhibitors
Fos-IR
serotonin
fed state
fasting state
topic serotonin reuptake inhibitors
Fos-IR
serotonin
fed state
fasting state
description Trabalho completo: acesso restrito, p. 327–334
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2012-08-31T19:26:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6675
dc.identifier.issn.none.fl_str_mv 0306-4522
dc.identifier.number.pt_BR.fl_str_mv v. 134, n. 1
identifier_str_mv 0306-4522
v. 134, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/6675
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.neuroscience.2005.03.010
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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collection Repositório Institucional da UFBA
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