Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Schriefer, Nicolaus Albert Borges
Data de Publicação: 1995
Outros Autores: Barral, Aldina Maria Prado, Carvalho Filho, Edgar Marcelino de, Barral-Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/8484
Resumo: Texto completo: acesso restrito. p.535–540
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spelling Schriefer, Nicolaus Albert BorgesBarral, Aldina Maria PradoCarvalho Filho, Edgar Marcelino deBarral-Netto, ManoelSchriefer, Nicolaus Albert BorgesBarral, Aldina Maria PradoCarvalho Filho, Edgar Marcelino deBarral-Netto, Manoel2013-02-18T15:56:36Z19950009-9104http://www.repositorio.ufba.br/ri/handle/ri/8484v. 102, n. 3Texto completo: acesso restrito. p.535–540Visceral leishmaniasis (VL) has a fatal course if not properly treated. Recovery from VL is linked to cellular immune response. Unresponsiveness to antimonial therapy reinforces the importance of determining parameters for treatment assessment. We analysed the pre- and post-treatment serum levels of solubleCD4(sCD4).sCD8. SI L-2R, soluble intercellular adhesion molecule-1 (sICAM-1) and neopterin in groups of VL patients either responsive or not to standard antimonial therapy. Pretreatment serum levels of all markers except for sICAM-1 were significantly higher in VL patients than in healthy subjects from the same area (P < 0 05). sICAM-1 levels were similar in healthy controls and in VL patients refractory to antimonial therapy (p = 0 25), but significantly higher in patients responsive to treatment (p = 0.02). The comparison of pre- and post-treatment concentrations showed that all markers, except sCD4 and sICAM-1, presented a significant fall (p < 0. 05) in patients responsive to antimonial therapy. However, only neopterin presented with levels compatible with those of healthy subjects at the end of treatment (p = 0. 30). In refractory patients sICAM-1 presented with post-treatment levels significantly higher than the pretreatment determinations (p = 0.03). while sCD4 experienced a significant drop (p = 0. 01) All markers displayed clearly distinct behaviour according to the patient's response to therapy. This makes all soluble molecules studied suitable for use as indicators of antimonial therapy response. Additionally the comparison of pretreatment levels of the markers between responders and refractory patients to antimonial therapy showed that serum concentrations of sIL-2R and sICAM-1 significantly differed among these two groups (p=0.02 in each case), suggesting that they may be used in future as predictors of antimonial therapy response.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-02-18T13:57:08Z No. of bitstreams: 1 Schriefer.pdf: 2268524 bytes, checksum: e8e962ba718d3d625d769652a59f69e6 (MD5)Approved for entry into archive by Fatima Cleômenis Botelho Maria (botelho@ufba.br) on 2013-02-18T15:56:36Z (GMT) No. of bitstreams: 1 Schriefer.pdf: 2268524 bytes, checksum: e8e962ba718d3d625d769652a59f69e6 (MD5)Made available in DSpace on 2013-02-18T15:56:36Z (GMT). No. of bitstreams: 1 Schriefer.pdf: 2268524 bytes, checksum: e8e962ba718d3d625d769652a59f69e6 (MD5) Previous issue date: 1995http://dx.doi.org/10.1111/j.1365-2249.1995.tb03849.xreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAvisceral leishmaniasissoluble markersantimonialSerum soluble markers in the evaluation of treatment in human visceral leishmaniasisClinical and Experimental Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALSchriefer.pdfSchriefer.pdfapplication/pdf2268524https://repositorio.ufba.br/bitstream/ri/8484/1/Schriefer.pdfe8e962ba718d3d625d769652a59f69e6MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/8484/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTSchriefer.pdf.txtSchriefer.pdf.txtExtracted texttext/plain26280https://repositorio.ufba.br/bitstream/ri/8484/3/Schriefer.pdf.txtf069775f30d80b455f934e9e4bd97972MD53ri/84842022-07-05 14:03:20.854oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:20Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis
dc.title.alternative.pt_BR.fl_str_mv Clinical and Experimental Immunology
title Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis
spellingShingle Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis
Schriefer, Nicolaus Albert Borges
visceral leishmaniasis
soluble markers
antimonial
title_short Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis
title_full Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis
title_fullStr Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis
title_full_unstemmed Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis
title_sort Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis
author Schriefer, Nicolaus Albert Borges
author_facet Schriefer, Nicolaus Albert Borges
Barral, Aldina Maria Prado
Carvalho Filho, Edgar Marcelino de
Barral-Netto, Manoel
author_role author
author2 Barral, Aldina Maria Prado
Carvalho Filho, Edgar Marcelino de
Barral-Netto, Manoel
author2_role author
author
author
dc.contributor.author.fl_str_mv Schriefer, Nicolaus Albert Borges
Barral, Aldina Maria Prado
Carvalho Filho, Edgar Marcelino de
Barral-Netto, Manoel
Schriefer, Nicolaus Albert Borges
Barral, Aldina Maria Prado
Carvalho Filho, Edgar Marcelino de
Barral-Netto, Manoel
dc.subject.por.fl_str_mv visceral leishmaniasis
soluble markers
antimonial
topic visceral leishmaniasis
soluble markers
antimonial
description Texto completo: acesso restrito. p.535–540
publishDate 1995
dc.date.issued.fl_str_mv 1995
dc.date.accessioned.fl_str_mv 2013-02-18T15:56:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/8484
dc.identifier.issn.none.fl_str_mv 0009-9104
dc.identifier.number.pt_BR.fl_str_mv v. 102, n. 3
identifier_str_mv 0009-9104
v. 102, n. 3
url http://www.repositorio.ufba.br/ri/handle/ri/8484
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1111/j.1365-2249.1995.tb03849.x
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collection Repositório Institucional da UFBA
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