Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Schriefer, Albert
Data de Publicação: 1995
Outros Autores: Barral, Aldina Maria Prado, Carvalho Filho, Edgar Marcelino, Barral Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7457
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil
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spelling Schriefer, AlbertBarral, Aldina Maria PradoCarvalho Filho, Edgar MarcelinoBarral Netto, Manoel2014-03-26T18:42:12Z2014-03-26T18:42:12Z1995SCHRIEFER, A. et al. Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis. Clinical Experimental and Immunology, v. 102, n. 3, p. 535-540, 1995.0009-9104https://www.arca.fiocruz.br/handle/icict/7457engBlackwell ScienceSerum soluble markers in the evaluation of treatment in human visceral leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Hospital Universitário Prof. Edgard Santos. Salvador, BA, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Hospital Universitário Prof. Edgard Santos. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, BrasilVisceral leishmaniasis (VL) has a fatal course if not properly treated. Recovery from VL is linked to cellular immune response. Unresponsiveness to antimonial therapy reinforces the importance of determining parameters for treatment assessment. We analysed the pre- and post-treatment serum levels of soluble CD4 (sCD4), sCD8, sIL-2R, soluble intercellular adhesion molecule- I (sICAM- 1) and neopterin in groups of VL patients either responsive or not to standard antimonial therapy. Pretreatment serum levels of all markers except for sICAM-1 were significantly higher in VL patients than in healthy subjects from the same area (P < 0-05). sICAM-1 levels were similar in healthy controls and in VL patients refractory to antimonial therapy (P= 0 25), but significantly higher in patients responsive to treatment (P = 0-02). The comparison of pre- and post-treatment concentrations showed that all markers, except sCD4 and sICAM-1, presented a significant fall (P < 0 05) in patients responsive to antimonial therapy. However, only neopterin presented with levels compatible with those of healthy subjects at the end of treatment (P = 0 30). In refractory patients sICAM-1 presented with post-treatment levels significantly higher than the pretreatment determinations (P=0003), while sCD4 experienced a significant drop (P=0001). All markers displayed clearly distinct behaviour according to the patient's response to therapy. This makes all soluble molecules studied suitable for use as indicators of antimonial therapy response. Additionally the comparison of pretreatment levels of the markers between responders and refractory patients to antimonial therapy showed that serum concentrations of sIL-2R and sICAM-1 significantly differed among these two groups (P= 0 02 in each case), suggesting that they may be used in future as predictors of antimonial therapy response.Visceral leishmaniasisSoluble markersantimonialLeishmaniose Visceral/imunologiaAntígenos CD4/sangueAntígenos CD8/sangueAntimônio/uso terapêuticoBiopterina/análogos & derivadosBiopterina/sangueHumanosMolécula 1 de Adesão Intercelular/sangueLeishmaniose Visceral/quimioterapiaNeopterinaReceptores de Interleucina-2/análiseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSchriefer A Serum Soluble....pdfSchriefer A Serum Soluble....pdfapplication/pdf938558https://www.arca.fiocruz.br/bitstream/icict/7457/1/Schriefer%20A%20Serum%20Soluble....pdf2a23fd655aa0247dcb22e071e2e56851MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7457/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSchriefer A Serum Soluble....pdf.txtSchriefer A Serum Soluble....pdf.txtExtracted texttext/plain26561https://www.arca.fiocruz.br/bitstream/icict/7457/5/Schriefer%20A%20Serum%20Soluble....pdf.txt7ecea75649d69226c5a88fbb7525de91MD55THUMBNAILSchriefer A Serum Soluble....pdf.jpgSchriefer A Serum Soluble....pdf.jpgGenerated Thumbnailimage/jpeg2358https://www.arca.fiocruz.br/bitstream/icict/7457/4/Schriefer%20A%20Serum%20Soluble....pdf.jpg2d582bf1819ec709b336cff753fc91d6MD54icict/74572023-03-15 14:33:23.2oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:23Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis
title Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis
spellingShingle Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis
Schriefer, Albert
Visceral leishmaniasis
Soluble markers
antimonial
Leishmaniose Visceral/imunologia
Antígenos CD4/sangue
Antígenos CD8/sangue
Antimônio/uso terapêutico
Biopterina/análogos & derivados
Biopterina/sangue
Humanos
Molécula 1 de Adesão Intercelular/sangue
Leishmaniose Visceral/quimioterapia
Neopterina
Receptores de Interleucina-2/análise
title_short Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis
title_full Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis
title_fullStr Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis
title_full_unstemmed Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis
title_sort Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis
author Schriefer, Albert
author_facet Schriefer, Albert
Barral, Aldina Maria Prado
Carvalho Filho, Edgar Marcelino
Barral Netto, Manoel
author_role author
author2 Barral, Aldina Maria Prado
Carvalho Filho, Edgar Marcelino
Barral Netto, Manoel
author2_role author
author
author
dc.contributor.author.fl_str_mv Schriefer, Albert
Barral, Aldina Maria Prado
Carvalho Filho, Edgar Marcelino
Barral Netto, Manoel
dc.subject.en.pt_BR.fl_str_mv Visceral leishmaniasis
Soluble markers
antimonial
topic Visceral leishmaniasis
Soluble markers
antimonial
Leishmaniose Visceral/imunologia
Antígenos CD4/sangue
Antígenos CD8/sangue
Antimônio/uso terapêutico
Biopterina/análogos & derivados
Biopterina/sangue
Humanos
Molécula 1 de Adesão Intercelular/sangue
Leishmaniose Visceral/quimioterapia
Neopterina
Receptores de Interleucina-2/análise
dc.subject.decs.pt_BR.fl_str_mv Leishmaniose Visceral/imunologia
Antígenos CD4/sangue
Antígenos CD8/sangue
Antimônio/uso terapêutico
Biopterina/análogos & derivados
Biopterina/sangue
Humanos
Molécula 1 de Adesão Intercelular/sangue
Leishmaniose Visceral/quimioterapia
Neopterina
Receptores de Interleucina-2/análise
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil
publishDate 1995
dc.date.issued.fl_str_mv 1995
dc.date.accessioned.fl_str_mv 2014-03-26T18:42:12Z
dc.date.available.fl_str_mv 2014-03-26T18:42:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SCHRIEFER, A. et al. Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis. Clinical Experimental and Immunology, v. 102, n. 3, p. 535-540, 1995.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7457
dc.identifier.issn.none.fl_str_mv 0009-9104
identifier_str_mv SCHRIEFER, A. et al. Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis. Clinical Experimental and Immunology, v. 102, n. 3, p. 535-540, 1995.
0009-9104
url https://www.arca.fiocruz.br/handle/icict/7457
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Blackwell Science
publisher.none.fl_str_mv Blackwell Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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