Clastogenic effect of extracts obtained from Crotalaria retusa L. and Crotalaria mucronata Desv. on mouse bone marrow cells

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Lúcia R.
Data de Publicação: 1993
Outros Autores: Silva, Ana Rita, Bautista, Ana Rita Pedreira Lapa, Costa, Silvia Lima, Sales, Liana A., Rios, Austregésilo C. C., Salvadori, Daisy Maria Favero
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/8685
Resumo: Texto completo: acesso restrito. p.253–258
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spelling Ribeiro, Lúcia R.Silva, Ana RitaBautista, Ana Rita Pedreira LapaCosta, Silvia LimaSales, Liana A.Rios, Austregésilo C. C.Salvadori, Daisy Maria FaveroRibeiro, Lúcia R.Silva, Ana RitaBautista, Ana Rita Pedreira LapaCosta, Silvia LimaSales, Liana A.Rios, Austregésilo C. C.Salvadori, Daisy Maria Favero2013-02-25T18:01:35Z19930027-5107http://www.repositorio.ufba.br/ri/handle/ri/8685v. 300, n. 3-4Texto completo: acesso restrito. p.253–258This work has evaluated the clastogenicity of six extracts (tea and aqueous extract of leaves, tea, aqueous and methanolic extracts of dried fruit, and tea of unripe fruit) obtained from Crotalaria retusa L. and three extracts (tea and methanolic extract of dried fruit, and tea of unripe fruit) obtained from Crotalaria mucronata Desv. The extracts were injected intraperitoneally into mice, and the animals were killed 24 h after treatment for preparation of bone marrow cells. The extracts obtained from fruits of Crotalaria retusa were found to cause a dose-dependent increase in the frequency of chromosomal aberrations in mice. On the other hand, no statistically significant increase in the frequency of aberrant cells was observed for the animals treated with leaf extracts obtained from Crotalaria retusa and with extracts from fruits of Crotalaria mucronata. The possibility that the pyrrolizidine alkaloid, monocrotaline, present in Crotalaria retusa exerts a clastogenic effect on mouse bone marrow cells is discussed. Our conclusion is based on studies using intraperitoneal treatments. Effects of oral exposure to extracts of Crotalaria retusa are unknown.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-02-22T12:26:59Z No. of bitstreams: 1 Ribeiro.pdf: 428679 bytes, checksum: 47f7ef3b7566fd80fa0c7379d96ae761 (MD5)Approved for entry into archive by Alda Lima da Silva(sivalda@ufba.br) on 2013-02-25T18:01:35Z (GMT) No. of bitstreams: 1 Ribeiro.pdf: 428679 bytes, checksum: 47f7ef3b7566fd80fa0c7379d96ae761 (MD5)Made available in DSpace on 2013-02-25T18:01:35Z (GMT). No. of bitstreams: 1 Ribeiro.pdf: 428679 bytes, checksum: 47f7ef3b7566fd80fa0c7379d96ae761 (MD5) Previous issue date: 1993http://dx.doi.org/10.1016/0165-1218(93)90058-Lreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACrotalaria retusaCrotalaria mucronataPyrrolizidine alkaloidsMonocrotalineChromosome aberrationsClastogenic effect of extracts obtained from Crotalaria retusa L. and Crotalaria mucronata Desv. on mouse bone marrow cellsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALRibeiro.pdfRibeiro.pdfapplication/pdf428679https://repositorio.ufba.br/bitstream/ri/8685/1/Ribeiro.pdf47f7ef3b7566fd80fa0c7379d96ae761MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/8685/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTRibeiro.pdf.txtRibeiro.pdf.txtExtracted texttext/plain20640https://repositorio.ufba.br/bitstream/ri/8685/3/Ribeiro.pdf.txtb749dede94e8ecd41c8cf85246ab81d5MD53ri/86852022-07-05 14:03:30.896oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:30Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Clastogenic effect of extracts obtained from Crotalaria retusa L. and Crotalaria mucronata Desv. on mouse bone marrow cells
dc.title.alternative.pt_BR.fl_str_mv Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
title Clastogenic effect of extracts obtained from Crotalaria retusa L. and Crotalaria mucronata Desv. on mouse bone marrow cells
spellingShingle Clastogenic effect of extracts obtained from Crotalaria retusa L. and Crotalaria mucronata Desv. on mouse bone marrow cells
Ribeiro, Lúcia R.
Crotalaria retusa
Crotalaria mucronata
Pyrrolizidine alkaloids
Monocrotaline
Chromosome aberrations
title_short Clastogenic effect of extracts obtained from Crotalaria retusa L. and Crotalaria mucronata Desv. on mouse bone marrow cells
title_full Clastogenic effect of extracts obtained from Crotalaria retusa L. and Crotalaria mucronata Desv. on mouse bone marrow cells
title_fullStr Clastogenic effect of extracts obtained from Crotalaria retusa L. and Crotalaria mucronata Desv. on mouse bone marrow cells
title_full_unstemmed Clastogenic effect of extracts obtained from Crotalaria retusa L. and Crotalaria mucronata Desv. on mouse bone marrow cells
title_sort Clastogenic effect of extracts obtained from Crotalaria retusa L. and Crotalaria mucronata Desv. on mouse bone marrow cells
author Ribeiro, Lúcia R.
author_facet Ribeiro, Lúcia R.
Silva, Ana Rita
Bautista, Ana Rita Pedreira Lapa
Costa, Silvia Lima
Sales, Liana A.
Rios, Austregésilo C. C.
Salvadori, Daisy Maria Favero
author_role author
author2 Silva, Ana Rita
Bautista, Ana Rita Pedreira Lapa
Costa, Silvia Lima
Sales, Liana A.
Rios, Austregésilo C. C.
Salvadori, Daisy Maria Favero
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ribeiro, Lúcia R.
Silva, Ana Rita
Bautista, Ana Rita Pedreira Lapa
Costa, Silvia Lima
Sales, Liana A.
Rios, Austregésilo C. C.
Salvadori, Daisy Maria Favero
Ribeiro, Lúcia R.
Silva, Ana Rita
Bautista, Ana Rita Pedreira Lapa
Costa, Silvia Lima
Sales, Liana A.
Rios, Austregésilo C. C.
Salvadori, Daisy Maria Favero
dc.subject.por.fl_str_mv Crotalaria retusa
Crotalaria mucronata
Pyrrolizidine alkaloids
Monocrotaline
Chromosome aberrations
topic Crotalaria retusa
Crotalaria mucronata
Pyrrolizidine alkaloids
Monocrotaline
Chromosome aberrations
description Texto completo: acesso restrito. p.253–258
publishDate 1993
dc.date.issued.fl_str_mv 1993
dc.date.accessioned.fl_str_mv 2013-02-25T18:01:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/8685
dc.identifier.issn.none.fl_str_mv 0027-5107
dc.identifier.number.pt_BR.fl_str_mv v. 300, n. 3-4
identifier_str_mv 0027-5107
v. 300, n. 3-4
url http://www.repositorio.ufba.br/ri/handle/ri/8685
dc.language.iso.fl_str_mv eng
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