The role of astrocytes in metabolism and neurotoxicity of the pyrrolizidine alkaloid monocrotaline, the main toxin of Crotalaria retusa

Detalhes bibliográficos
Autor(a) principal: Costa, Silvia Lima
Data de Publicação: 2012
Outros Autores: Pitanga, Bruno Penas Seara, Nascimento, Ravena Pereira do, Silva, Victor Diógenes A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15252
Resumo: Texto completo: acesso restrito. p. 1-7
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spelling Costa, Silvia LimaPitanga, Bruno Penas SearaNascimento, Ravena Pereira doSilva, Victor Diógenes A.Costa, Silvia LimaPitanga, Bruno Penas SearaNascimento, Ravena Pereira doSilva, Victor Diógenes A.2014-07-21T16:54:53Z20121663-9812http://repositorio.ufba.br/ri/handle/ri/15252v. 3Texto completo: acesso restrito. p. 1-7The metabolic interactions and signaling between neurons and glial cells are necessary for the development and maintenance of brain functions and structures and for neuroprotection, which includes protection from chemical attack. Astrocytes are essential for cerebral detoxification and present an efficient and specific cytochrome P450 enzymatic system. Whilst Crotalaria (Fabaceae, Leguminosae) plants are used in popular medicine, they are considered toxic and can cause damage to livestock and human health problems. Studies in animals have shown cases of poisoning by plants from the genus Crotalaria, which induced damage to the central nervous system. This finding has been attributed to the toxic effects of the pyrrolizidine alkaloid (PA) monocrotaline (MCT). The involvement of P450 enzymatic systems in MCT hepatic and pulmonary metabolism and toxicity has been elucidated, but little is known about the pathways implicated in the bioactivation of these systems and the direct contribution of these systems to brain toxicity. This review will present the main toxicological aspects of the Crotalaria genus that are established in the literature and recent findings describing the mechanisms involved in the neurotoxic effects of MCT, which was extracted from Crotalaria retusa, and its interaction with neurons in isolated astrocytes.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-07-08T13:42:32Z No. of bitstreams: 1 Silvia L. Costa.pdf: 941974 bytes, checksum: f17028f7b0bd807581ddd2b236fc47d3 (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-07-21T16:54:53Z (GMT) No. of bitstreams: 1 Silvia L. Costa.pdf: 941974 bytes, checksum: f17028f7b0bd807581ddd2b236fc47d3 (MD5)Made available in DSpace on 2014-07-21T16:54:53Z (GMT). No. of bitstreams: 1 Silvia L. Costa.pdf: 941974 bytes, checksum: f17028f7b0bd807581ddd2b236fc47d3 (MD5) Previous issue date: 2012http://dx.doi.org/ 10.3389/fphar.2012.00144reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACrotalariaPyrrolizidine alkaloidMonocrotalineNeurotoxicityAstrocyteneuronP450GSHThe role of astrocytes in metabolism and neurotoxicity of the pyrrolizidine alkaloid monocrotaline, the main toxin of Crotalaria retusaFrontiers in Pharmacologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALSilvia L. Costa.pdfSilvia L. 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dc.title.pt_BR.fl_str_mv The role of astrocytes in metabolism and neurotoxicity of the pyrrolizidine alkaloid monocrotaline, the main toxin of Crotalaria retusa
dc.title.alternative.pt_BR.fl_str_mv Frontiers in Pharmacology
title The role of astrocytes in metabolism and neurotoxicity of the pyrrolizidine alkaloid monocrotaline, the main toxin of Crotalaria retusa
spellingShingle The role of astrocytes in metabolism and neurotoxicity of the pyrrolizidine alkaloid monocrotaline, the main toxin of Crotalaria retusa
Costa, Silvia Lima
Crotalaria
Pyrrolizidine alkaloid
Monocrotaline
Neurotoxicity
Astrocyte
neuron
P450
GSH
title_short The role of astrocytes in metabolism and neurotoxicity of the pyrrolizidine alkaloid monocrotaline, the main toxin of Crotalaria retusa
title_full The role of astrocytes in metabolism and neurotoxicity of the pyrrolizidine alkaloid monocrotaline, the main toxin of Crotalaria retusa
title_fullStr The role of astrocytes in metabolism and neurotoxicity of the pyrrolizidine alkaloid monocrotaline, the main toxin of Crotalaria retusa
title_full_unstemmed The role of astrocytes in metabolism and neurotoxicity of the pyrrolizidine alkaloid monocrotaline, the main toxin of Crotalaria retusa
title_sort The role of astrocytes in metabolism and neurotoxicity of the pyrrolizidine alkaloid monocrotaline, the main toxin of Crotalaria retusa
author Costa, Silvia Lima
author_facet Costa, Silvia Lima
Pitanga, Bruno Penas Seara
Nascimento, Ravena Pereira do
Silva, Victor Diógenes A.
author_role author
author2 Pitanga, Bruno Penas Seara
Nascimento, Ravena Pereira do
Silva, Victor Diógenes A.
author2_role author
author
author
dc.contributor.author.fl_str_mv Costa, Silvia Lima
Pitanga, Bruno Penas Seara
Nascimento, Ravena Pereira do
Silva, Victor Diógenes A.
Costa, Silvia Lima
Pitanga, Bruno Penas Seara
Nascimento, Ravena Pereira do
Silva, Victor Diógenes A.
dc.subject.por.fl_str_mv Crotalaria
Pyrrolizidine alkaloid
Monocrotaline
Neurotoxicity
Astrocyte
neuron
P450
GSH
topic Crotalaria
Pyrrolizidine alkaloid
Monocrotaline
Neurotoxicity
Astrocyte
neuron
P450
GSH
description Texto completo: acesso restrito. p. 1-7
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-07-21T16:54:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15252
dc.identifier.issn.none.fl_str_mv 1663-9812
dc.identifier.number.pt_BR.fl_str_mv v. 3
identifier_str_mv 1663-9812
v. 3
url http://repositorio.ufba.br/ri/handle/ri/15252
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.3389/fphar.2012.00144
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instacron_str UFBA
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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