Cross-sectional study of endothelial function in HIV-infected patients in Brazil

Detalhes bibliográficos
Autor(a) principal: Andrade, Ana Cristina O.
Data de Publicação: 2008
Outros Autores: Ladeia, Ana Marice Teixeira, M. Netto, Eduardo M., Mascarenhas, Amanda, Cotter, Bruno, Benson, Constance A., Badaró, Roberto José da Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14490
Resumo: Texto completo: acesso restrito. p. 27-33
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spelling Andrade, Ana Cristina O.Ladeia, Ana Marice TeixeiraM. Netto, Eduardo M.Mascarenhas, AmandaCotter, BrunoBenson, Constance A.Badaró, Roberto José da SilvaAndrade, Ana Cristina O.Ladeia, Ana Marice TeixeiraM. Netto, Eduardo M.Mascarenhas, AmandaCotter, BrunoBenson, Constance A.Badaró, Roberto José da Silva2014-01-28T14:28:00Z20080889-2229http://repositorio.ufba.br/ri/handle/ri/14490v. 24, n. 1Texto completo: acesso restrito. p. 27-33Antiretroviral therapy (ART) in HIV-infected patients has been associated with an increased risk of cardiovascular disease. This study evaluates vascular endothelial dysfunction of the peripheral circulation in Brazilian HIV-infected subjects on ART or naive to ART compared to a control group matched for age and body mass index (BMI). We performed a cross-sectional comparative study to measure postischemic peak flow-mediated dilation (FMD) of the brachial artery and the response to glyceryl trinitrate (GTN) in HIV-infected patients and healthy controls in Salvador, Bahia, Brazil. Endothelial vasomotor function was evaluated by assessing brachial artery FMD. Forty-four HIV-infected individuals (33 ARV treated and 11 ART naive) were compared to 25 healthy controls matched for age and BMI. FMD % was significantly lower for the ART-experienced patients compared to the ART-naive patients and was also significantly different from controls (ART experienced 8.2 ± 6.0% vs. 19.3 ± 4.8% vs. 23.3 ± 6.1%), respectively (p < 0.0001). The cholesterol, triglyceride, and ALT levels were significantly higher in the ART-experienced group compared to the ART-naive and control subjects (p < 0.028); however, linear regression analysis revealed a statistically significant association of endothelial dysfunction as a dependent variable only with ARV treatment in HIV-infected subjects (p = 0.03). The association of endothelial dysfunction with ARV therapy in HIV-infected patients was independent of protease inhibitor-containing regimens or dyslipidemia. This dysfunction may contribute to the risk for HIV-associated atherosclerosis.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-12-17T11:21:04Z No. of bitstreams: 1 aid%2E2006%2E0281.pdf: 131072 bytes, checksum: 544620c95fa8eff27252b745af0be606 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-01-28T14:28:00Z (GMT) No. of bitstreams: 1 aid%2E2006%2E0281.pdf: 131072 bytes, checksum: 544620c95fa8eff27252b745af0be606 (MD5)Made available in DSpace on 2014-01-28T14:28:00Z (GMT). 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dc.title.pt_BR.fl_str_mv Cross-sectional study of endothelial function in HIV-infected patients in Brazil
dc.title.alternative.pt_BR.fl_str_mv AIDS Research and Human Retroviruses
title Cross-sectional study of endothelial function in HIV-infected patients in Brazil
spellingShingle Cross-sectional study of endothelial function in HIV-infected patients in Brazil
Andrade, Ana Cristina O.
AIDS Serodiagnosis
Atherosclerosis
title_short Cross-sectional study of endothelial function in HIV-infected patients in Brazil
title_full Cross-sectional study of endothelial function in HIV-infected patients in Brazil
title_fullStr Cross-sectional study of endothelial function in HIV-infected patients in Brazil
title_full_unstemmed Cross-sectional study of endothelial function in HIV-infected patients in Brazil
title_sort Cross-sectional study of endothelial function in HIV-infected patients in Brazil
author Andrade, Ana Cristina O.
author_facet Andrade, Ana Cristina O.
Ladeia, Ana Marice Teixeira
M. Netto, Eduardo M.
Mascarenhas, Amanda
Cotter, Bruno
Benson, Constance A.
Badaró, Roberto José da Silva
author_role author
author2 Ladeia, Ana Marice Teixeira
M. Netto, Eduardo M.
Mascarenhas, Amanda
Cotter, Bruno
Benson, Constance A.
Badaró, Roberto José da Silva
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Ana Cristina O.
Ladeia, Ana Marice Teixeira
M. Netto, Eduardo M.
Mascarenhas, Amanda
Cotter, Bruno
Benson, Constance A.
Badaró, Roberto José da Silva
Andrade, Ana Cristina O.
Ladeia, Ana Marice Teixeira
M. Netto, Eduardo M.
Mascarenhas, Amanda
Cotter, Bruno
Benson, Constance A.
Badaró, Roberto José da Silva
dc.subject.por.fl_str_mv AIDS Serodiagnosis
Atherosclerosis
topic AIDS Serodiagnosis
Atherosclerosis
description Texto completo: acesso restrito. p. 27-33
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2014-01-28T14:28:00Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14490
dc.identifier.issn.none.fl_str_mv 0889-2229
dc.identifier.number.pt_BR.fl_str_mv v. 24, n. 1
identifier_str_mv 0889-2229
v. 24, n. 1
url http://repositorio.ufba.br/ri/handle/ri/14490
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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