Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor

Detalhes bibliográficos
Autor(a) principal: Lima, Rosangela G.
Data de Publicação: 2006
Outros Autores: Moreira, Letícia, Paes Leme, Joana, Souza, Victor Barreto de, Faria Neto, Hugo C. Castro, Bozza, Patrícia Torres, Bou-Habib, Dumith Chequer
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12447
Resumo: Texto completo: acesso restrito. p.763–769
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spelling Lima, Rosangela G.Moreira, LetíciaPaes Leme, JoanaSouza, Victor Barreto deFaria Neto, Hugo C. CastroBozza, Patrícia TorresBou-Habib, Dumith ChequerLima, Rosangela G.Moreira, LetíciaPaes Leme, JoanaSouza, Victor Barreto deFaria Neto, Hugo C. CastroBozza, Patrícia TorresBou-Habib, Dumith Chequer2013-08-05T12:51:30Z20060889-2229http://www.repositorio.ufba.br/ri/handle/ri/12447v.22 n. 8Texto completo: acesso restrito. p.763–769Phagocytosis of apoptotic cells by macrophages increases secretion of soluble mediators and generates an antiinflammatory environment. We previously reported that phagocytosis of apoptotic cells by HIV-1-infected macrophages enhances viral replication, with the participation of the cytokine transforming growth factor- β1 and an integrin receptor. Now, we describe the role of prostaglandin E2 (PGE2), platelet-activating factor (PAF), and the integrin α V β 3 (vitronectin receptor, VnR) in this phenomenon. Exacerbation of HIV-1 growth induced by phagocytosis of apoptotic cells was inhibited when HIV-1-infected macrophages were treated with a cyclooxygenase 2 inhibitor, or with a PAF receptor antagonist (BN 52021) immediately after macrophage interaction with apoptotic cells. Treatment of HIV-1-infected macrophages with BN 52021 decreased viral replication, whereas addition of PGE2 or PAF to these cells enhanced viral replication. Monoclonal antibodies (MAbs) to VnR reduced the macrophage uptake of apoptotic cells, prevented the enhancement of HIV-1 growth upon the engulfment of apoptotic cells, and potently augmented viral replication in HIV-1-infected macrophages in the absence of apoptotic cells. In conclusion, PGE2 and PAF, and ligation of VnR as well, contribute to amplify viral growth in HIV-1-infected macrophages upon uptake of apoptotic cells.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-08-01T18:17:08Z No. of bitstreams: 1 aid.2006.22.pdf: 165364 bytes, checksum: a6889fc0e5435daf769b58c07c4978a7 (MD5)Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-08-05T12:51:30Z (GMT) No. of bitstreams: 1 aid.2006.22.pdf: 165364 bytes, checksum: a6889fc0e5435daf769b58c07c4978a7 (MD5)Made available in DSpace on 2013-08-05T12:51:30Z (GMT). No. of bitstreams: 1 aid.2006.22.pdf: 165364 bytes, checksum: a6889fc0e5435daf769b58c07c4978a7 (MD5) Previous issue date: 2006http://online.liebertpub.com.ez10.periodicos.capes.gov.br/doi/abs/10.1089/aid.2006.22.763reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAMacrophagesAIDS SerodiagnosisVitronectinInteraction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin ReceptorAIDS Research and Human Retrovirusesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALaid.2006.22.pdfaid.2006.22.pdfapplication/pdf165364https://repositorio.ufba.br/bitstream/ri/12447/1/aid.2006.22.pdfa6889fc0e5435daf769b58c07c4978a7MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12447/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTaid.2006.22.pdf.txtaid.2006.22.pdf.txtExtracted texttext/plain38862https://repositorio.ufba.br/bitstream/ri/12447/3/aid.2006.22.pdf.txtacf01d50c3669383907d6fccecd93514MD53ri/124472022-07-05 14:02:50.303oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:50Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor
dc.title.alternative.pt_BR.fl_str_mv AIDS Research and Human Retroviruses
title Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor
spellingShingle Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor
Lima, Rosangela G.
Macrophages
AIDS Serodiagnosis
Vitronectin
title_short Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor
title_full Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor
title_fullStr Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor
title_full_unstemmed Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor
title_sort Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor
author Lima, Rosangela G.
author_facet Lima, Rosangela G.
Moreira, Letícia
Paes Leme, Joana
Souza, Victor Barreto de
Faria Neto, Hugo C. Castro
Bozza, Patrícia Torres
Bou-Habib, Dumith Chequer
author_role author
author2 Moreira, Letícia
Paes Leme, Joana
Souza, Victor Barreto de
Faria Neto, Hugo C. Castro
Bozza, Patrícia Torres
Bou-Habib, Dumith Chequer
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Rosangela G.
Moreira, Letícia
Paes Leme, Joana
Souza, Victor Barreto de
Faria Neto, Hugo C. Castro
Bozza, Patrícia Torres
Bou-Habib, Dumith Chequer
Lima, Rosangela G.
Moreira, Letícia
Paes Leme, Joana
Souza, Victor Barreto de
Faria Neto, Hugo C. Castro
Bozza, Patrícia Torres
Bou-Habib, Dumith Chequer
dc.subject.por.fl_str_mv Macrophages
AIDS Serodiagnosis
Vitronectin
topic Macrophages
AIDS Serodiagnosis
Vitronectin
description Texto completo: acesso restrito. p.763–769
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2013-08-05T12:51:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12447
dc.identifier.issn.none.fl_str_mv 0889-2229
dc.identifier.number.pt_BR.fl_str_mv v.22 n. 8
identifier_str_mv 0889-2229
v.22 n. 8
url http://www.repositorio.ufba.br/ri/handle/ri/12447
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://online.liebertpub.com.ez10.periodicos.capes.gov.br/doi/abs/10.1089/aid.2006.22.763
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collection Repositório Institucional da UFBA
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