Association of human T lymphotropic virus 1 amplification of periodontitis severity with altered cytokine expression in response to a standard periodontopathogen infection

Detalhes bibliográficos
Autor(a) principal: Garlet, Gustavo Pompermaier
Data de Publicação: 2010
Outros Autores: Giozza, Silvana Pereira, Silveira, Elcia Maria, Claudino, Marcela, Santos, Silvane Maria Braga, Carvalho Filho, Edgar Marcelino de, Campos, Mario Julio Avila
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13670
Resumo: Texto completo: acesso restrito. p.e11-e18
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spelling Garlet, Gustavo PompermaierGiozza, Silvana PereiraSilveira, Elcia MariaClaudino, MarcelaSantos, Silvane Maria BragaCarvalho Filho, Edgar Marcelino deCampos, Mario Julio AvilaGarlet, Gustavo PompermaierGiozza, Silvana PereiraSilveira, Elcia MariaClaudino, MarcelaSantos, Silvane Maria BragaCarvalho Filho, Edgar Marcelino deCampos, Mario Julio Avila2013-11-16T13:00:10Z20101328-8067http://repositorio.ufba.br/ri/handle/ri/13670v. 50, n. 3Texto completo: acesso restrito. p.e11-e18Background. Periodontal diseases (PDs) are infectious diseases in which periodontopathogens trigger chronic inflammatory and immune responses that lead to tissue destruction. Recently, viruses have been implicated in the pathogenesis of PDs. Individuals infected with human T lymphotropic virus 1 (HTLV-1) present with abnormal oral health and a marked increased prevalence of periodontal disease. Methods. In this study, we investigated the patterns of periodontopathogen infection and local inflammatory immune markers in HTLV-1–seropositive individuals with chronic periodontitis (CP/HTLV-1 group) compared with HTLV-1–seronegative individuals with chronic periodontitis (CP group) and periodontally healthy, HTLV-1–seronegative individuals (control group). Results. Patients in the CP/HTLV-1 group had significantly higher values of bleeding on probing, mean probing depth, and attachment loss than patients in the CP group. The expression of tumor necrosis factor α and interleukin (IL) 4 was found to be similar in the CP and CP/HTLV-1 groups, whereas IL-12 and IL-17 levels trended toward a higher expression in the CP/HTLV-1 group. A significant increase was seen in the levels of IL-1β and interferon γ in the CP/HTLV-1 group compared with the CP group, whereas expression of the regulatory T cell marker FOXp3 and IL-10 was significantly decreased in the lesions from the CP/HTLV-1 group. Interestingly, similar frequency and/or load of periodontopathogens (Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Aggregatibacter actinomycetemcomitans) and frequency of viruses (herpes simplex virus 1, human cytomegalovirus, and Epstein-Barr virus) characteristically associated with PDs were found in the CP/HTLV and CP groups. Conclusions. HTLV-1 may play a critical role in the pathogenesis of periodontal disease through the deregulation of the local cytokine network, resulting in an exacerbated response against a standard periodontopathogen infection.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-09-09T17:36:32Z No. of bitstreams: 1 Clin Infect Dis.-2010-Garlet-e11-8.pdf: 227353 bytes, checksum: 6514f1c2568d6b22b2d7f1cd5c69d329 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-16T13:00:10Z (GMT) No. of bitstreams: 1 Clin Infect Dis.-2010-Garlet-e11-8.pdf: 227353 bytes, checksum: 6514f1c2568d6b22b2d7f1cd5c69d329 (MD5)Made available in DSpace on 2013-11-16T13:00:10Z (GMT). No. of bitstreams: 1 Clin Infect Dis.-2010-Garlet-e11-8.pdf: 227353 bytes, checksum: 6514f1c2568d6b22b2d7f1cd5c69d329 (MD5) Previous issue date: 2010http://dx.doi.org/10.1086/649871reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAssociation of human T lymphotropic virus 1 amplification of periodontitis severity with altered cytokine expression in response to a standard periodontopathogen infectionPediatrics Internationalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALClin Infect Dis.-2010-Garlet-e11-8.pdfClin Infect Dis.-2010-Garlet-e11-8.pdfapplication/pdf227353https://repositorio.ufba.br/bitstream/ri/13670/1/Clin%20Infect%20Dis.-2010-Garlet-e11-8.pdf6514f1c2568d6b22b2d7f1cd5c69d329MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13670/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTClin Infect Dis.-2010-Garlet-e11-8.pdf.txtClin Infect Dis.-2010-Garlet-e11-8.pdf.txtExtracted texttext/plain39494https://repositorio.ufba.br/bitstream/ri/13670/3/Clin%20Infect%20Dis.-2010-Garlet-e11-8.pdf.txt5b4923170eec4ac70debacd65bb346d0MD53ri/136702022-07-05 14:03:15.487oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:15Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Association of human T lymphotropic virus 1 amplification of periodontitis severity with altered cytokine expression in response to a standard periodontopathogen infection
dc.title.alternative.pt_BR.fl_str_mv Pediatrics International
title Association of human T lymphotropic virus 1 amplification of periodontitis severity with altered cytokine expression in response to a standard periodontopathogen infection
spellingShingle Association of human T lymphotropic virus 1 amplification of periodontitis severity with altered cytokine expression in response to a standard periodontopathogen infection
Garlet, Gustavo Pompermaier
title_short Association of human T lymphotropic virus 1 amplification of periodontitis severity with altered cytokine expression in response to a standard periodontopathogen infection
title_full Association of human T lymphotropic virus 1 amplification of periodontitis severity with altered cytokine expression in response to a standard periodontopathogen infection
title_fullStr Association of human T lymphotropic virus 1 amplification of periodontitis severity with altered cytokine expression in response to a standard periodontopathogen infection
title_full_unstemmed Association of human T lymphotropic virus 1 amplification of periodontitis severity with altered cytokine expression in response to a standard periodontopathogen infection
title_sort Association of human T lymphotropic virus 1 amplification of periodontitis severity with altered cytokine expression in response to a standard periodontopathogen infection
author Garlet, Gustavo Pompermaier
author_facet Garlet, Gustavo Pompermaier
Giozza, Silvana Pereira
Silveira, Elcia Maria
Claudino, Marcela
Santos, Silvane Maria Braga
Carvalho Filho, Edgar Marcelino de
Campos, Mario Julio Avila
author_role author
author2 Giozza, Silvana Pereira
Silveira, Elcia Maria
Claudino, Marcela
Santos, Silvane Maria Braga
Carvalho Filho, Edgar Marcelino de
Campos, Mario Julio Avila
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Garlet, Gustavo Pompermaier
Giozza, Silvana Pereira
Silveira, Elcia Maria
Claudino, Marcela
Santos, Silvane Maria Braga
Carvalho Filho, Edgar Marcelino de
Campos, Mario Julio Avila
Garlet, Gustavo Pompermaier
Giozza, Silvana Pereira
Silveira, Elcia Maria
Claudino, Marcela
Santos, Silvane Maria Braga
Carvalho Filho, Edgar Marcelino de
Campos, Mario Julio Avila
description Texto completo: acesso restrito. p.e11-e18
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2013-11-16T13:00:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13670
dc.identifier.issn.none.fl_str_mv 1328-8067
dc.identifier.number.pt_BR.fl_str_mv v. 50, n. 3
identifier_str_mv 1328-8067
v. 50, n. 3
url http://repositorio.ufba.br/ri/handle/ri/13670
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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